Accelerator mass spectrometry measurement of intracellular concentrations of active drug metabolites in human target cells in vivo

Clinical Pharmacology and Therapeutics

Volumn 88, Issue 6, 2010, Pages 796-800

  Chen, J ^a,e   Garner, R C ^a   Lee, L S ^b   Seymour, M ^a   Fuchs, E J ^a   Hubbard, W C ^a   Parsons, T L ^c   Pakes, G E ^d   Fletcher, C V ^a   Flexner, C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Xceleron Ltd   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e Garner Consulting Services   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; TRACER; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE C 14; ZIDOVUDINE GLUCURONIDE; ZIDOVUDINE TRIPHOSPHATE;

ACCELERATOR MASS SPECTROMETRY; ADULT; ARTICLE; DRUG BIOAVAILABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; INTERMETHOD COMPARISON; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TARGET CELL;

ADULT; CHROMATOGRAPHY, LIQUID; DRUG DELIVERY SYSTEMS; HUMANS; INTRACELLULAR FLUID; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; TANDEM MASS SPECTROMETRY; ZIDOVUDINE;

EID: 78449283598     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.188     Document Type: Article

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