Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartum

Journal of Clinical Pharmacology

Volumn 50, Issue 11, 2010, Pages 1301-1309

  Eyal, Sara ^a   Kim, Joong D ^a   Anderson, Gail D ^a   Buchanan, Megan L ^a   Brateng, Debra A ^b   Carr, Darcy ^b   Woodrum, David E ^b   Easterling, Thomas R ^b   Hebert, Mary F ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Department of Obstetrics An Gynecology ^*  (Australia)

Author keywords

Atenolol; breast milk; kidney function; pharmacokinetics; postpartum

Indexed keywords

ATENOLOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; BREAST FEEDING; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG HALF LIFE; DRUG MILK LEVEL; DRUG WITHDRAWAL; FEMALE; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; HYPERTROPHIC CARDIOMYOPATHY; INFANT; MAXIMUM PLASMA CONCENTRATION; PUERPERIUM; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; ANTIHYPERTENSIVE AGENTS; ATENOLOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; LACTATION; MALE; MILK, HUMAN; POSTPARTUM PERIOD; PREGNANCY; TIME FACTORS;

EID: 78449283438     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270009358708     Document Type: Article

References (33)

1. American Academy of Pediatrics, Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics. 2001 ; 108: 776-779.
2. Tenormin® product labeling. Wilmington, Del: AstraZeneca ; 2008.
3. Schmimmel MS, Eidelman AJ, Wilschanski MA, Shaw D., Ogilvie RJ, Koren G. Toxic effects of atenolol consumed during breast feeding. J Pediatr. 1989 ; 114: 476-478.
4. Fowler MB, Brudenell M., Jackson G., Holt DW Essential hypertension and pregnancy: successful outcome with atenolol. Br J Clin Pract. 1984 ; 38: 73-74.
5. White WB, Andreoli JW, Wong SH, Cohn RD Atenolol in human plasma and breast milk. Obstet Gynecol. 1984 ; 63 (3 suppl). 42S-44S.
6. Kulas J., Lunell NO, Rosing U., Steen B., Rane A. Atenolol and metoprolol: a comparison of their excretion into human breast milk. Acta Obstet Gynecol Scand Suppl. 1984 ; 118: 65-69.
7. Liedholm H. Transplacental passage and breast milk accumulation of atenolol in humans. Drugs. 1983 ; 25 (suppl 2). 217-218.
8. Thorley KJ, McAinsh J. Levels of the beta-blockers atenolol and propranolol in the breast milk of women treated for hypertension in pregnancy. Biopharm Drug Dispos. 1983 ; 4: 299-301.
9. Hebert MF, Carr DB, Anderson GD, et al. Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum. J Clin Pharmacol. 2005 ; 45: 25-33.
10. World Health Organization. Fifty-Fifth World Health Assembly. Infant and Young Child Nutrition. Global Strategy on Infant and Young Child Feeding. Report by the Secretariat. A55 / 15. Basel, Switzerland: World Health Organization ; April 16, 2002.
11. American Academy of Pediatrics Work Group on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 1997 ; 100: 1035-1039.
12. Ito S., Lee A. Drug excretion into breast milk-overview. Adv Drug Deliv Rev. 2003 ; 55: 617-627.
13. National Center for Health Statistics and the National Center for Chronic Disease Prevention and Health Promotion. Birth to 36 months: girls, length-for-age and weight-for-age percentiles. http://www.cdc.gov/growthcharts. May 30, 2000 ; modified April 20, 2001. Accessed February 15, 2009.
14. Diamond JM Toxic effects of atenolol consumed during breast feeding. J Pediatr. 1989 ; 115: 336.
15. Koren G. Toxic effects of atenolol consumed during breast feeding. J Pediatr. 1989 ; 115: 336-337.
16. Hale TW Medications and Mother's Milk. 13 th ed. Amarillo, Tex: Hale ; 2008.
17. Trippel DL, Gillette PC Atenolol in children with supraventricular tachycardia. Am J Cardiol. 1989 ; 64: 233-236.
18. Mehta AV, Subrahmanyam AB, Anand R. Long-term efficacy and safety of atenolol for supraventricular tachycardia in children. Pediatr Cardiol. 1996 ; 17: 231-236.
19. Luedtke SA, Kuhn RJ, McCaffrey FM Pharmacologic management of supraventricular tachycardias in children, part 2: atrial flutter, atrial fibrillation, and junctional and atrial ectopic tachycardia. Ann Pharmacother. 1997 ; 31: 1347-1359.
20. Högstedt S., Lindberg B., Peng DR, Regà¥rdh CG, Rane A. Pregnancy-induced increase in metoprolol metabolism. Clin Pharmacol Ther. 1985 ; 37: 688-692.
21. Högstedt S., Lindberg B., Rane A. Increased oral clearance of metoprolol in pregnancy. Eur J Clin Pharmacol. 1983 ; 24: 217-220. 22. Abdel Razek A., Az El-Dein N. Effect of breast-feeding on pain relief during infant immunization injections. Int J Nurs Pract. 2009 ; 15: 99-104.
22. Efe E., Ozer ZC The use of breast-feeding for pain relief during neonatal immunization injections. Appl Nurs Res. 2007 ; 20: 10-16.
23. Gray L., Miller LW, Philipp BL, Blass EM Breastfeeding is analgesic in healthy newborns. Pediatrics. 2002 ; 109: 590-593.
24. Kato Y., Miyazaki T., Kano T., Sugiura T., Kubo Y., Tsuji A. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 ; 98: 2529-2539.
25. Alcorn J., Lu X., Moscow JA, McNamara PJ Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther. 2002 ; 303: 487-496.
26. Davison JM, Dunlop W., Ezimokhai M. 24-hour creatinine clearance during the third trimester of normal pregnancy. Br J Obstet Gynaecol. 1980 ; 87: 106-109.
27. Ronco C., Brendolan A., Bragantini L., et al. Renal functional reserve in pregnancy. Nephrol Dial Transplant. 1988 ; 2: 157-161.
28. Noel GL, Suh HK, Frantz AG Prolactin release during nursing and breast stimulation in postpartum and nonpostpartum subjects. J Clin Endocrinol Metab. 1974 ; 38: 413-423.
29. Tyson JE, Friesen HG, Anderson MS Human lactational and ovarian response to endogenous prolactin release. Science. 1972 ; 177: 897-900.
30. Hennart P., Delogne-Desnoeck J., Vis H., Robyn C. Serum levels of prolactin and milk production in women during a lactation period of thirty months. Clin Endocrinol (Oxf). 1981 ; 14: 349-353.
31. Buckman MT, Peake GT, Roberson G. Hyperprolactinemia influences renal function in man. Metabolism. 1976 ; 25: 509-516.
32. Morrissey SE, Newth T., Rees R., Barr A., Shora F., Laycock JF Renal effects of recombinant prolactin in anaesthetized rats. Eur J Endocrinol. 2001 ; 145: 65-71.
33. Rubin PC, Butters L., Reynolds B., et al. Atenolol elimination in the neonate. Br J Clin Pharmacol. 1983 ; 16: 659-662.