Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors

Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry

Volumn 49, Issue 11, 2010, Pages 1499-1508

  Gao, Y L ^a   Zhao, G L ^b   Liu, W ^b   Shao, H ^b   Wang, Y L ^b   Tang, L D ^b   Wang, J W ^a  

^a SHANDONG UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Hypoglycemic activity; N glycoside; SGLT2 inhibitor; Synthesis; Tetrazole

Indexed keywords

EID: 78449276475     PISSN: 03764699     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Arakawa K, Ishihara T, Oku A, Nawano M, Ueta K, Kitamura K, Matsumoto M & Saito A, Brit J Pharmacol, 132,2001, 578.
2. Meng M, Ellsworth B A, Nirschl A A, McCann P J, Patel M, Girotra R N, Wu G, Sher P M, Morrison E P, Biller S A, Zahler R, Deshpande P P, Pullockaran A, Hagan D L, Morgan N N, Taylor J R, Obermeier M T, Humphreys W G, Khanna A, Discenza L, Robertson J M, Wang A, Han S, Wetterau J R, Janovitz E B, Flint O P, Whaley J M & Washburn W N, J Med Chem, 51,2008,1145.
3. Link J T & Sorensen B K, Tetrahedron Lett, 41,2000, 9213.
4. Tsujihara K, Hongu M, Saito K, Inamasu M, Arakawa K, Oku A & Matsumoto M, Chem Pharm Bull, 44,1996,1174.
5. Katsuno K, Fujimori Y, Takemura Y, Hiratochi M, Itoh F, Komatsy Y, Fujikura H & Isaji M, J Pharmacol Exp Ther, 320, 2007, 323.
6. Zhao G L, Yu Z Y, Li Y, Pang L N & Wang J W, Chin J Chem, 26, 2008,158.