Use of SFC/MS in the purification of achiral pharmaceutical compounds

American Pharmaceutical Review

Volumn 13, Issue 6, 2010, Pages 111-115

  Van Anda, Jennifer ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACHIRAL COMPOUND; AMINE; CHEMICAL COMPOUND; METHANOL; PYRIDINE; UNCLASSIFIED DRUG;

APPARATUS; DRUG PURIFICATION; EQUIPMENT DESIGN; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SHORT SURVEY; SUPERCRITICAL FLUID CHROMATOGRAPHY; TURNAROUND TIME;

EID: 78449270819     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (5)

1. Taylor, L.T."Supercritical Fluid Chromatography" (2008) Anal. Chem. 80 pp.4285-4294.
2. Zhang, X., Towle, M.H., Felice, C.E., Flament, J.H., and Goetzinger, W.K., "Development of a Mass-Directed Preparative Supercritical Fluid Chromatography Purification System" (2006) J. Comb.Chem. 8, 705-714. (Pubitemid 44578627)
3. White, C and Burnett, J., "Integration of Supercritical Fluid Chromatography into Drug Discovery as a Routine Support Tool: II. Investigation and Evaluation of Supercritical Fluid Chromatography for achiral Batch Purification" (2005) Journal Chrom. A, 1074, pp.175-185. (Pubitemid 40615055)
4. Phinney, K.W., Sander, L.C., and Wise, S.A. "Coupled Achiral/Chiral Column Techniques in Subcritical Fluid Chromatography for the Separation of Chiral and Nonchiral Compounds" (1998) Anal.Chem,70 pp.2331-2335.
5. Yan, T.Q., Bradow, J., Chang, S.P., Depoanta, R., and Phillippe, L. "Approaches to Singleton Achiral; Purification of Difficult Samples for Discovery Research Support" (2009) LCGC North America April.