Improvement of physical activity as an alternative objective variable to measure treatment effects of anticachexia therapy in cancer patients

Current Opinion in Supportive and Palliative Care

Volumn 4, Issue 4, 2010, Pages 259-265

  Mantovani, Giovanni ^a,b   Madeddu, Clelia ^a   Serpe, Roberto ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b DEPARTMENT OF RADIOLOGY   (Italy)

Author keywords

Active energy expenditure; Body worn physical activity meter; Cachexia; Lean body mass; Physical activity

Indexed keywords

ARTICLE; CACHEXIA; CLINICAL TRIAL (TOPIC); ENERGY METABOLISM; HUMAN; METABOLISM; MONITORING; MOTOR ACTIVITY; NEOPLASM; PHYSIOLOGY; QUALITY OF LIFE;

CACHEXIA; CLINICAL TRIALS AS TOPIC; ENERGY METABOLISM; HUMANS; MONITORING, PHYSIOLOGIC; MOTOR ACTIVITY; NEOPLASMS; QUALITY OF LIFE;

EID: 78449254543     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0b013e32833b35c0     Document Type: Article

References (15)

1. Evans WJ, Morley JE, Argiles J, et al. Cachexia: A new definition. Clin Nutr 2008; 27:793-799.
2. Mantovani G,Maccio A, Madeddu C, et al. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Oncologist 2010; 15:200-211. This is the first phase III randomized study with a very large number of patients with an innovative approach and the assessment of precise primary endpoints, such as LBM, REE and fatigue.
3. Prince SA, Adamo KB, Hamel ME, et al. A comparison of direct versus selfreport measures for assessing physical activity in adults: A systematic review. Int J Behav Nutr Phys Act 2008; 5:56.
4. Dahele M, Skipworth RJ, Wall L, et al. Objective physical activity and selfreported quality of life in patients receiving palliative chemotherapy. J Pain Symptom Manage 2007; 33:676-685.
5. Maddocks M, Byrne A, Johnson CD, et al. Physical activity level as an outcome measure for use in cancer cachexia trials: A feasibility study. Support Care Cancer 2009. Dec 3. [Epub ahead of print This paper describes the first 'validation study' that formally assessed the acceptability of the use of a physical activity monitor as an acceptable method of providing an assessment of free living physical activity in patients with cancer.
6. Zhang K, Pi-Sunyer FX, Boozer CN. Improving energy expenditure estimation for physical activity. Med Sci Sports Exerc 2004; 36:883-889.
7. Hustvedt BE, Christophersen A, Johnsen LR, et al. Description and validation of the ActiReg: A novel instrument to measure physical activity and energy expenditure. Br J Nutr 2004; 92:1001-1008.
8. Moses AW, Slater C, Preston T, et al. Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer 2004; 90:996-1002.
9. Fouladiun M, Korner U, Gunnebo L, et al. Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexia. Clin Cancer Res 2007; 13:6379-6385.
10. Lundholm K, Gunnebo L, Korner U, et al. Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: A randomized doubleblind study. Cancer 2010; 116:2044-2052. The authors assessed the spontaneous daily physical activity with an arm band sensor of cachectic cancer patients treated with high-dose and low-dose ghrelin, respectively. They concluded that improvements by ghrelin did not induce increased physical activityand, thus, were used preferentially for the protection of energy stores.
11. Strasser F. Diagnostic criteria of cachexia and their assessment: Decreased muscle strength and fatigue. Curr Opin Clin Nutr Metab Care 2008; 11:417-421.
12. Jones LW, Eves ND, Haykowsky M, et al. Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol 2009; 10:598-605. This paper is an interesting review that highlights that exercise training is associated with improvements in quality of life, exercise capacity, physical functioning and fatigue and that the preliminary evidence of a benefit of exercise for patients with cancer is promising.
13. Mourtzakis M, Prado CM, Lieffers JR, et al. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab 2008; 33:997-1006.
14. Prado CM, Birdsell LA, Baracos VE. The emerging role of computerized tomography in assessing cancer cachexia. Curr Opin Support Palliat Care 2009; 3:269-275. This article focuses on the potential opportunistic use of computerized tomography to enhance our understanding of abnormal body composition, specifically lean and adipose tissue chances, in cancer cachexia: Hence, L3-CT is currently considered themost sophisticated method to assess body composition in cancer cachexia.
15. Stein KD, Martin SC, Hann DM, et al. A multidimensional measure of fatigue for use with cancer patients. Cancer Pract 1998; 6:143-152.