Reduced iNOS expression in adenoids from children with otitis media with effusion

Pediatric Allergy and Immunology

Volumn 21, Issue 8, 2010, Pages 1151-1156

  Granath, Anna ^a   Norrby Teglund, Anna ^a   Uddman, Rolf ^b   Cardell, Lars Olaf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Adenoids; Endothelial NO synthases; IL 1 ; Inducible NO synthases; Otitis media with effusion; TNF

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADENOID; ADOLESCENT; ARTICLE; CHILD; CHRONIC SECRETORY OTITIS MEDIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NASOPHARYNGEAL ASPIRATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION;

ADENOIDS; ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; FEMALE; HUMANS; HYPERTROPHY; INFLAMMATION; INTERLEUKIN-1BETA; MALE; NITRIC OXIDE SYNTHASE TYPE II; OTITIS MEDIA WITH EFFUSION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78449250776     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2010.01020.x     Document Type: Article

References (23)

1. Chantzi FM, Papadopoulos NG, Bairamis T, et al. Human rhinoviruses in otitis media with effusion. Pediatr Allergy Immunol 2006: 17: 514-8.
2. Bluestone CD. Studies in otitis media: Children's Hospital of Pittsburgh-University of Pittsburgh progress report-2004. Laryngoscope 2004: 114: 1-26.
3. Suenaga S, Kodama S, Ueyama S, Suzuki M, Mogi G. Mucosal immunity of the middle ear: analysis at the single cell level. Laryngoscope 2001: 111: 290-6.
4. Zuercher AW, Coffin SE, Thurnheer MC, Fundova P, Cebra JJ. Nasal-associated lymphoid tissue is a mucosal inductive site for virus-specific humoral and cellular immune responses. J Immunol 2002: 168: 1796-803.
5. Andersson JA, Cervin A, Lindberg S, Uddman R, Cardell LO. The paranasal sinuses as reservoirs for nitric oxide. Acta Otolaryngol 2002: 122: 861-5.
6. Lundberg JO, Lundberg JM, Alving K, Weitzberg E. Nitric oxide and inflammation: the answer is blowing in the wind. Nat Med 1997: 3: 30-1.
7. Scadding G. Nitric oxide in the airways. Curr Opin Otolaryngol Head Neck Surg 2007: 15: 258-63.
8. Cardell LO, Agusti C, Nadel JA. Nitric oxide-dependent neutrophil recruitment: role in nasal secretion. Clin Exp Allergy 2000: 30: 1799-803.
9. Nagy G, Koncz A, Fernandez D, Perl A. Nitric oxide, mitochondrial hyperpolarization, and T cell activation. Free Radic Biol Med 2007: 42: 1625-31.
10. Akaike T, Maeda H. Nitric oxide and virus infection. Immunology 2000: 101: 300-8.
11. Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001: 2: 907-16.
12. Andersson JA, Uddman R, Tajti J, Cardell L-O. Heme oxygenase and nitric oxide synthase in human middle ear epithelium indicates local carbon monoxide and nitric oxide production. Acta Otolaryngol 2002: 122: 634-7.
13. Forseni M, Bagger-Sjoback D, Hultcrantz M. A study of inflammatory mediators in the human tympanosclerotic middle ear. Arch Otolaryngol Head Neck Surg 2001: 127: 559-64.
14. Rahman S, Gudetta B, Fink J, et al. Compartmentalization of immune responses in human tuberculosis. Few CD8+ effector T cells but elevated levels of FoxP3+ regulatory T Cells in the granulomatous lesions. Am J Pathol 2009: 174: 2211-24.
15. Norrby-Teglund A, Thulin P, Gan BS, et al. Evidence for superantigen involvement in severe group a streptococcal tissue infections. J Infect Dis 2001: 184: 853-60.
16. Lundberg JON, Farkas-Szallasi T, Weitzberg E, et al. High nitric oxide production in human paranasal sinuses. Nat Med 1995: 1: 370-3.
17. Bogdan C, Rollinghoff M, Diefenbach A. The role of nitric oxide in innate immunity. Immunol Rev 2000: 173: 17-26.
18. Kleinert H, Schwarz PM, Forstermann U. Regulation of the expression of inducible nitric oxide synthase. Biol Chem 2003: 384: 1343-64.
19. Granath A, Uddman R, Cardell L-O. Increased TLR7 expression in the adenoids among children with otitis media with effusion. Acta Otolaryngol 2009: 19: 1-5, (e-published ahead of print).
20. Lindberg K, Rynnel-Dagoo B, Sundqvist KG. Cytokines in nasopharyngeal secretions; evidence for defective IL-1 beta production in children with recurrent episodes of acute otitis media. Clin Exp Immunol 1994: 97: 396-402.
21. Maw AR, Herod F. Otoscopic, impedance and audiometric findings in glue ear treated by adenoidectomy and tonsillectomy: a prospective randomised study. The Lancet 1986: 327: 1399-402.
22. Ball SS, Prazma J, Dais D, Rosbe KW, Pillsbury HC. Nitric oxide: a mediator of endotoxin-induced middle ear effusions. Laryngoscope 1996: 106: 1021-7.
23. Ryan AF, Bennett T. Nitric oxide contributes to control of effusion in experimental otitis media. Laryngoscope 2001: 111: 301-5.