Identification of a novel pyrrole derivative endowed with antimycobacterial activity and protection index comparable to that of the current antitubercular drugs streptomycin and rifampin

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 8076-8084

  Biava, Mariangela ^a   Porretta, Giulio Cesare ^a   Poce, Giovanna ^a   Battilocchio, Claudio ^a   Alfonso, Salvatore ^a   Logu, Alessandro De ^b   Serra, Nadia ^b   Manetti, Fabrizio ^c   Botta, Maurizio ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Dipartimento di Scienze e Tecnologie Biomediche   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Cytotoxicity; Pharmacophore model; Protection index; Pyrroles; Tuberculosis

Indexed keywords

4 [[1 (4 FLUOROPHENYL) 2 METHYL 5 [4 (METHYLTHIO)PHENYL] 1H PYRROL 3 YL]METHYL]THIOMORPHOLINE; BM 521; PYRROLE DERIVATIVE; RIFAMPICIN; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SAFETY; DRUG STRUCTURE; INFECTION PREVENTION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; CERCOPITHECUS AETHIOPS; MYCOBACTERIUM TUBERCULOSIS; PYRROLES; RIFAMPIN; STREPTOMYCIN; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78449242124     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.006     Document Type: Article

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