Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation

Developmental Biology

Volumn 348, Issue 2, 2010, Pages 224-230

  Haussmann, Irmgard U ^a   Soller, Matthias ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Alternative splicing; Functional genomics; Synaptic growth; Transcription factor activity; Transcriptional and post transcriptional gene regulatory networks

Indexed keywords

ERECT WING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DROSOPHILA; EMBRYO; EXON; GENE CONTROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GROWTH REGULATION; MUTANT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; SYNAPTOGENESIS; TRANSGENE;

EID: 78349309492     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2010.09.006     Document Type: Article

References (30)

1. Becker T.S., Burgess S.M., Amsterdam A.H., Allende M.L., Hopkins N. not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development 1998, 125:4369-4378.
2. Bogarad L.D., Arnone M.I., Chang C., Davidson E.H. Interference with gene regulation in living sea urchin embryos: transcription factor knock out (TKO), a genetically controlled vector for blockade of specific transcription factors. Proc. Natl Acad. Sci. USA 1998, 95:14827-14832.
3. Calzone F.J., Hoog C., Teplow D.B., Cutting A.E., Zeller R.W., Britten R.J., Davidson E.H. Gene regulatory factors of the sea urchin embryo. I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein. Development 1991, 112:335-350.
4. DeSimone S., Coelho C., Roy S., VijayRaghavan K., White K. ERECT WING, the Drosophila member of a family of DNA binding proteins is required in imaginal myoblasts for flight muscle development. Development 1996, 122:31-39.
5. DeSimone S.M., White K. The Drosophila erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the sea urchin P3A2 DNA binding protein. Mol. Cell. Biol. 1993, 13:3641-3649.
6. Dhar S.S., Liang H.L., Wong-Riley M.T. Nuclear respiratory factor 1 co-regulates AMPA glutamate receptor subunit 2 and cytochrome c oxidase: tight coupling of glutamatergic transmission and energy metabolism in neurons. J. Neurochem. 2009, 108:1595-1606.
7. Dhar S.S., Ongwijitwat S., Wong-Riley M.T. Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons. J. Biol. Chem. 2008, 283:3120-3129.
8. Dhar S.S., Wong-Riley M.T. Coupling of energy metabolism and synaptic transmission at the transcriptional level: role of nuclear respiratory factor 1 in regulating both cytochrome c oxidase and NMDA glutamate receptor subunit genes. J. Neurosci. 2009, 29:483-492.
9. Dubnau J., Chiang A.S., Grady L., Barditch J., Gossweiler S., McNeil J., Smith P., Buldoc F., Scott R., Certa U., Broger C., Tully T. The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr. Biol. 2003, 13:286-296.
10. Efiok B.J., Chiorini J.A., Safer B. A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J. Biol. Chem. 1994, 269:18921-18930.
11. Fazio I.K., Bolger T.A., Gill G. Conserved regions of the Drosophila erect wing protein contribute both positively and negatively to transcriptional activity. J. Biol. Chem. 2001, 276:18710-18716.
12. Gugneja S., Scarpulla R.C. Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. J. Biol. Chem. 1997, 272:18732-18739.
13. Haussmann I.U., White K., Soller M. Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. Genome Biol. 2008, 9:R73.
14. Huo L., Scarpulla R.C. Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol. Cell. Biol. 2001, 21:644-654.
15. Keleman K., Kruttner S., Alenius M., Dickson B.J. Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. Nat. Neurosci. 2007, 10:1587-1593.
16. Kirchhamer C.V., Davidson E.H. Spatial and temporal information processing in the sea urchin embryo: modular and intramodular organization of the CyIIIa gene cis-regulatory system. Development 1996, 122:333-348.
17. Koushika S.P., Soller M., DeSimone S.M., Daub D.M., White K. Differential and inefficient splicing of a broadly expressed Drosophila erect wing transcript results in tissue-specific enrichment of the vital EWG protein isoform. Mol. Cell. Biol. 1999, 19:3998-4007.
18. Koushika S.P., Soller M., White K. The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein. Mol. Cell. Biol. 2000, 20:1836-1845.
19. Kwak J.E., Drier E., Barbee S.A., Ramaswami M., Yin J.C., Wickens M. GLD2 poly(A) polymerase is required for long-term memory. Proc. Natl Acad. Sci. USA 2008, 105:14644-14649.
20. Lahey T., Gorczyca M., Jia X.X., Budnik V. The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure. Neuron 1994, 13:823-835.
21. Lee T., Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 1999, 22:451-461.
22. Li Q., Lee J.A., Black D.L. Neuronal regulation of alternative pre-mRNA splicing. Nat. Rev. Neurosci. 2007, 8:819-831.
23. Newsome T.P., Asling B., Dickson B.J. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 2000, 127:851-860.
24. Si K., Giustetto M., Etkin A., Hsu R., Janisiewicz A.M., Miniaci M.C., Kim J.H., Zhu H., Kandel E.R. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell 2003, 115:893-904.
25. Soller M. Pre-messenger RNA processing and its regulation: a genomic perspective. Cell. Mol. Life Sci. 2006, 63:796-819.
26. Soller M., Haussmann I.U., Hollmann M., Choffat Y., White K., Kubli E., Schafer M.A. Sex-peptide-regulated female sexual behavior requires a subset of ascending ventral nerve cord neurons. Curr. Biol. 2006, 16:1771-1782.
27. Soller M., Li M., Haussmann I.U. Regulation of the ELAV target ewg: insights from an evolutionary perspective. Biochem. Soc. Trans. 2008, 36:502-504.
28. Soller M., White K. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Genes Dev. 2003, 17:2526-2538.
29. Struhl G., Adachi A. Nuclear access and action of notch in vivo. Cell 1998, 93:649-660.
30. Virbasius C.A., Virbasius J.V., Scarpulla R.C. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev. 1993, 7:2431-2445.