SOX10 expression in superficial spreading and nodular malignant melanomas

Melanoma Research

Volumn 20, Issue 6, 2010, Pages 468-478

  Agnarsdóttir, Margrét ^a   Sooman, Linda ^a   Bolander, Åsa ^a   Strömberg, Sara ^a   Rexhepaj, Elton ^e   Bergqvist, Michael ^a   Ponten, Fredrik ^a   Gallagher, William ^e   Lennartsson, Johan ^b   Ekman, Simon ^a   Uhlen, Mathias ^d   Hedstrand, Håkan ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d ALBANOVA UNIVERSITY CENTER   (Sweden)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

immunohistochemistry; malignant melanoma; small interfering RNA; SOX10

Indexed keywords

KI 67 ANTIGEN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX10;

ARTICLE; CANCER RECURRENCE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MELANOCYTE; MELANOMA; MULTIVARIATE ANALYSIS; NEVUS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN TUMOR; TISSUE MICROARRAY; TUMOR CELL;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; DOWN-REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MELANOMA; NEOPLASM METASTASIS; RNA, SMALL INTERFERING; SKIN NEOPLASMS; SOXE TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 78349306096     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/CMR.0b013e3283403ccd     Document Type: Article

References (42)

1. Schepers GE, Teasdale RD, Koopman P. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 2002; 3:167-170.
2. Harris ML, Baxter LL, Loftus SK, Pavan WJ. Sox proteins in melanocyte development and melanoma. Pigment Cell Melanoma Res 2010; 23:496-513.
3. Sinclair AH, Berta P, Palmer MS, Hawkins JR, Griffiths BL, Smith MJ, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990; 346:240-244.
4. Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Munsterberg A, et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 1990; 346:245-250.
5. Huang X, Saint-Jeannet JP. Induction of the neural crest and the opportunities of life on the edge. Dev Biol 2004; 275:1-11.
6. Kuhlbrodt K, Herbarth B, Sock E, Hermans-Borgmeyer I, Wegner M. Sox10, a novel transcriptional modulator in glial cells. J Neurosci 1998; 18: 237-250.
7. Kim J, Lo L, Dormand E, Anderson DJ. SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells. Neuron 2003; 38:17-31.
8. Kelsh RN. Sorting out Sox10 functions in neural crest development. Bioessays 2006; 28:788-798.
9. Pingault V, Bondurand N, Kuhlbrodt K, Goerich DE, Prehu MO, Puliti A, et al. SOX10 mutations in patients with Waardenburg-Hirschsprung disease. Nat Genet 1998; 18:171-173.
10. Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA, et al. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 1993; 74:395-404.
11. Lee M, Goodall J, Verastegui C, Ballotti R, Goding CR. Direct regulation of the microphthalmia promoter by Sox10 links Waardenburg-Shah syndrome (WS4)-associated hypopigmentation and deafness to WS2. J Biol Chem 2000; 275:37978-37983.
12. Verastegui C, Bille K, Ortonne JP, Ballotti R. Regulation of the microphthalmia-associated transcription factor gene by the Waardenburg syndrome type 4 gene, SOX10. J Biol Chem 2000; 275:30757-30760.
13. Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, et al. Frequent mutations in the MITF pathway in melanoma. Pigment Cell Melanoma Res 2009; 22:435-444.
14. Flammiger A, Besch R, Cook AL, Maier T, Sturm RA, Berking C. SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells. J Invest Dermatol 2009; 129:945-953.
15. Fang D, Nguyen TK, Leishear K, Finko R, Kulp AN, Hotz S, et al. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res 2005; 65:9328-9337.
16. Huang EH, Heidt DG, Li CW, Simeone DM. Cancer stem cells: a new paradigm for understanding tumor progression and therapeutic resistance. Surgery2007; 141:415-419.
17. Nonaka D, Chiriboga L, Rubin BP. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol 2008; 32:1291-1298.
18. Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol 2008; 35:433-444.
19. Blochin E, Nonaka D. Diagnostic value of Sox10 immunohistochemical staining for the detection of metastatic melanoma in sentinel lymph nodes. Histopathology 2009; 55:626-628.
20. Honore SM, Aybar MJ, Mayor R. Sox10 is required for the early development of the prospective neural crest in Xenopus embryos. Dev Biol 2003; 260:79-96.
21. Finzsch M, Stolt CC, Lommes P, Wegner M. Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. Development 2008; 135:637-646.
22. Zhu YT, Jia Y, Hu L, Qi C, Prasad MK, McCallion AS, et al. Peroxisome-proliferator-activated receptor-binding protein (PBP) is essential for the growth of active Notch4-immortalized mammary epithelial cells by activating SOX10 expression. Biochem J 2009; 425:435-444.
23. Morokuma J, Blackiston D, Adams DS, Seebohm G, Trimmer B, Levin M. Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. Proc Natl Acad Sci USA 2008; 105:16608-16613.
24. McKeown SJ, Lee VM, Bronner-Fraser M, Newgreen DF, Farlie PG. Sox10 overexpression induces neural crest-like cells from all dorsoventral levels of the neural tube but inhibits differentiation. Dev Dyn 2005; 233:430-444.
25. Drerup CM, Wiora HM, Topczewski J, Morris JA. Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development2009; 136:2623-2632.
26. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development 2005; 132:4937-4950.
27. Bolander A, Agnarsdottir M, Stromberg S, Ponten F, Hesselius P, Uhlen M, et al. The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas. Cancer Genomics Proteomics 2008; 5:293-300.
28. UICC. TNM Atlas. International Union Agains Cancer. 5th ed. New York: Wiley-Blackwell; 2004. pp. 201-206.
29. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998; 4:844-847.
30. Kampf C, Andersson AC, Wester K, Björling E, Uhlen M, Ponten F. Antibody-based tissue profiling as a tool for clinical proteomics. Clin Proteomics 2004; 1:285-299.
31. Rexhepaj E, Brennan DJ, Holloway P, Kay EW, McCann AH, Landberg G, et al. Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer. Breast Cancer Res 2008; 10:R89.
32. Gallagher WM, Bergin OE, Rafferty M, Kelly ZD, Nolan IM, Fox EJ, et al. Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies. Carcinogenesis 2005; 26: 1856-1867.
33. Amagasaki K, Kaneto H, Heldin CH, Lennartsson J. c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts. J Biol Chem 2006; 281: 22173-22179.
34. Stromberg S, Agnarsdottir M, Magnusson K, Rexhepaj E, Bolander A, Lundberg E, et al. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. J Proteome Res 2009; 8:1639-1646.
35. Hazan C, Melzer K, Panageas KS, Li E, Kamino H, Kopf A, et al. Evaluation of the proliferation marker MIB-1 in the prognosis of cutaneous malignant melanoma. Cancer 2002; 95:634-640.
36. Alonso SR, Ortiz P, Pollan M, Perez-Gomez B, Sanchez L, Acuna MJ, et al. Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study. Am J Pathol 2004; 164:193-203.
37. Bakos RM, Maier T, Besch R, Mestel DS, Ruzicka T, Sturm RA, et al. Nestin and SOX9 and SOX10 transcription factors are coexpressed in melanoma. Exp Dermatol2010; 19:e89-e94.
38. Mulrane L, Rexhepaj E, Penney S, Callanan JJ, Gallagher WM. Automated image analysis in histopathology: a valuable tool in medical diagnostics. Expert Rev Mol Diagn 2008; 8:707-725.
39. Decaestecker C, Lopez XM, D'Haene N, Roland I, Guendouz S, Duponchelle C, et al. Requirements for the valid quantification of immunostains on tissue microarray materials using image analysis. Proteomics 2009; 9:4478-4494.
40. Camp RL, Neumeister V, Rimm DL. A decade of tissue microarrays: progress in the discovery and validation of cancer biomarkers. J Clin Oncol2008; 26:5630-5637.
41. Cook AL, Smith AG, Smit DJ, Leonard JH, Sturm RA. Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Exp Cell Res 2005; 308:222-235.
42. Hoek KS, Schlegel NC, Brafford P, Sucker A, Ugurel S, Kumar R, et al. Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res 2006; 19:290-302.