Evaluation of treatment with a combination of azathioprine and prednisone in dogs with meningoencephalomyelitis of undetermined etiology: 40 cases (2000-2007)

Journal of the American Veterinary Medical Association

Volumn 237, Issue 8, 2010, Pages 929-935

  Wong, Michael A ^a,b   Hopkins, Andrew L ^a   Meeks, John C ^a   Clarke, Jeff D ^a  

^a North Florida Neurology   (United States)

^b Southeast Veterinary Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; IMMUNOSUPPRESSIVE AGENT; PREDNISONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DOG DISEASE; FEMALE; MALE; MENINGOENCEPHALITIS; RETROSPECTIVE STUDY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AZATHIOPRINE; DOG DISEASES; DOGS; FEMALE; IMMUNOSUPPRESSIVE AGENTS; MALE; MENINGOENCEPHALITIS; PREDNISONE; RETROSPECTIVE STUDIES;

EID: 78349297846     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.237.8.929     Document Type: Article

References (31)

1. Cherubini GB, Platt SR, Anderson TJ, et al. Characteristics of magnetic resonance images of granulomatous meningoencephalomyelitis in 11 dogs. Vet Rec 2006;159:110-115.
2. Tipold A. Diagnosis of inflammatory and infectious diseases of the central nervous system in dogs: a retrospective study. J Vet Intern Med 1995;9:304-314.
3. Thomas JB, Eger C. Granulomatous meningoencephalomyelitis in 21 dogs. J Small Anim Pract 1989;30:287-293.
4. Sorjonen DC. Clinical and histopathological features of granulomatous meningoencephalomyelitis in dogs. J Am Anim Hosp Assoc 1990;26:141-147.
5. Bailey CS, Higgins RJ. Characteristics of cerebrospinal fluid associated with canine granulomatous meningoencephalomyelitis: a retrospective study. J Am Vet Med Assoc 1986;188:418-421.
6. Zarfoss M, Schatzberg S, Venator K, et al. Combined cytosine arabinoside and prednisone therapy for meningoencephalitis of unknown aetiology in 10 dogs. J Small Anim Pract 2006;47:588-595.
7. Muñana KR, Luttgen PJ. Prognostic factors for dogs with granulomatous meningoencephalomyelitis: 42 cases (1982-1996). J Am Vet Med Assoc 1998;212:1902-1906.
8. Vandevelde M, Fatzer R, Fankhauser R. Immunohistological studies on primary reticulosis of the canine brain. Vet Pathol 1981;18:577-588.
9. Kipar A, Baumgartner W, Vogl C, et al. Immunohistochemical characterization of inflammatory cells in brains of dogs with granulomatous meningoencephalitis. Vet Pathol 1998;35:43-52.
10. Coates JR, Barone G, Dewey C W, et al. Procarbazine as adjunctive therapy for dogs with presumptive antemortem diagnosis of granulomatous meningoencephalomyelitis: 21 cases (1998-2004). J Vet Intern Med 2007;21:100-106.
11. Cuddon PA, Coates JR, Murray M. New treatments for granulomatous meningoencephalomyelitis, in Proceedings. 20th Am Coll Vet Intern Med Forum 2002;141-147.
12. Nuhsbaum MT, Powell CC, Gionfriddo JR, et al. Treatment of granulomatous meningoencephalomyelitis in a dog. Vet Ophthalmol 2002;5:29-33.
13. Adamo F P, O'Brien RT. Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs. J Am Vet Med Assoc 2004;225:1211-1216.
14. Adamo P F, Rylander H, Adams WM. Ciclosporin use in multidrug therapy for meningoencephalomyelitis of unknown aetiology in dogs. J Small Anim Pract 2007;48:486-496.
15. Gnirs K. Ciclosporin treatment of suspected granulomatous meningoencephalitis in three dogs. J Small Anim Pract 2006;47:201-206.
16. Jung DI, Kang BT, Park C, et al. A comparison of combination therapy (cyclosporine plus prednisolone) with sole prednisolone therapy in 7 dogs with necrotizing meningoencephalitis. J Vet Med Sci 2007;69:1303-1306.
17. Menaut P, Landart J, Behr S, et al. Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside. Vet Rec 2008;162:241-245.
18. Smith PM, Stalin CE, Shaw D, et al. Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology. J Vet Intern Med 2009;23:520-526.
19. Beale KM. Azathioprine for treatment of immune-mediated diseases of dogs and cats. J Am Vet Med Assoc 1988;192:1316-1318.
20. Miller E. Immunosuppressive therapy in the treatment of immune-mediated disease. J Vet Intern Med 1992;6:206-213.
21. Rinkardt NE, Kruth SA. Azathioprine-induced bone marrow toxicity in four dogs. Can Vet J 1996;37:612-613.
22. Beale KM, Altman D, Clemmons RM, et al. Systemic toxicosis associated with azathioprine administration in domestic cats. Am J Vet Res 1992;53:1236-1240.
23. Plumb DC. Azathioprine/azathioprine sodium. In: Plumb DC, ed. Plumb's veterinary drug handbook. 5th ed. Ames, Iowa: Blackwell Publishing, 2005;78-80.
24. Gregory CR. Immunosuppressive agents. In: Bonagura JD, Twedt DC, eds. Kirk's current veterinary therapy XIV. St Louis: Saunders Co, 2009;254-259.
25. Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999). J Am Vet Med Assoc 2001;218:543-546.
26. Dewey C W, Coates JR, Ducote JM, et al. Azathioprine therapy for acquired myasthenia gravis in five dogs. J Am Anim Hosp Assoc 1999;35:396-402.
27. Dewey C W. Encephalopathies: disorders of the brain. In: Dewey C W, ed. A practical guide to canine and feline neurology. Ames, Iowa: Iowa State Press, 2003;99-178.
28. Harris C W, Didier PJ, Parker AJ. Simultaneous central nervous system reticulosis in two related Afghan hounds. Compend Contin Educ Pract Vet 1988;10:304-310.
29. Miller E. CVT update: diagnosis and treatment of immunemediated hemolytic anemia. In: Bonagura JD, ed. Kirk's current veterinary therapy XIII: small animal practice. Philadelphia: Saunders Co, 2000;427-434.
30. Lowrie M, Penderis J, McLaughlin M, et al. Steroid responsive meningitis arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). J Vet Intern Med 2009;23:862-870.
31. International Agency for Research on Cancer website. Azathioprine. Available at: www.monographs.iarc.fr/ENG/Monographs/suppl7/suppl7-23.pdf. Accessed Dec. 19, 2008.