Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matter

Journal of Magnetic Resonance Imaging

Volumn 32, Issue 5, 2010, Pages 1054-1060

  Schmierer, Klaus ^a,b   Thavarajah, Janet R ^a   An, Shu F ^a   Brandner, Sebastian ^a   Miller, David H ^a   Tozer, Daniel J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

cortex; cortical lesions; fixation effects; magnetization transfer; multiple sclerosis; postmortem; T1

Indexed keywords

FORMALDEHYDE; MYELIN;

ARTICLE; AUTOPSY; CORRELATION ANALYSIS; CORTICAL GRAY MATTER; DEMYELINATION; FEMALE; GRAY MATTER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

CEREBRAL CORTEX; FIXATIVES; FORMALDEHYDE; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; MULTIPLE SCLEROSIS; POSTMORTEM CHANGES; TISSUE FIXATION;

EID: 78349291194     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.22381     Document Type: Article

References (37)

1. Compston A, Coles A., Multiple sclerosis. Lancet 2008; 372: 1502-1517.
2. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria.". Ann Neurol 2005; 58: 840-846.
3. Miller DH, Weinshenker BG, Filippi M, et al. Differential diagnosis of suspected multiple sclerosis: a consensus approach. Mult Scler 2008; 14: 1157-1174.
4. Barkhof F, Calabresi PA, Miller DH, Reingold SC., Imaging outcomes for neuroprotection and repair in multiple sclerosis trials. Nat Rev Neurol 2009; 5: 256-266.
5. Bo L, Geurts JJ, Ravid R, Barkhof F., Magnetic resonance imaging as a tool to examine the neuropathology of multiple sclerosis. Neuropathol Appl Neurobiol 2004; 30: 106-117.
6. Franklin RJ, ffrench-Constant C., Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839-855.
7. Schmierer K, Scaravilli F, Altmann DR, Barker GJ, Miller DH., Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 2004; 56: 407-415.
8. MacKay AL, Vavasour IM, Rauscher A, et al. MR relaxation in multiple sclerosis. Neuroimaging Clin N Am 2009; 19: 1-26.
9. Barkhof F, Bruck W, De Groot CJ, et al. Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance. Arch Neurol 2003; 60: 1073-1081.
10. Shepherd TM, Thelwall PE, Stanisz GJ, Blackband SJ., Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue. Magn Reson Med 2009; 62: 26-34.
11. Schmierer K, Wheeler-Kingshott CA, Tozer DJ, et al. Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation. Magn Reson Med 2008; 59: 268-277.
12. Pelvig DP, Pakkenberg H, Stark AK, Pakkenberg B., Neocortical glial cell numbers in human brains. Neurobiol Aging 2008; 29: 1754-1762.
13. Davison AN, Wajda M., Analysis of lipids from fresh and preserved adult human brains. Biochem J 1962; 82: 113-117.
14. Parker GJ, Barker GJ, Tofts PS., Accurate multislice gradient echo T(1) measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity. Magn Reson Med 2001; 45: 838-845.
15. Barker GJ, Tofts PS, Gass A., An interleaved sequence for accurate and reproducible clinical measurement of magnetization transfer ratio. Magn Reson Imaging 1996; 14: 403-411.
16. Davies GR, Tozer DJ, Cercignani M, et al. Estimation of the macromolecular proton fraction and bound pool T2 in multiple sclerosis. Mult Scler 2004; 10: 607-613.
17. Henkelman RM, Huang X, Xiang QS, Stanisz GJ, Swanson SD, Bronskill MJ., Quantitative interpretation of magnetization transfer. Magn Reson Med 1993; 29: 759-766.
18. Ramani A, Dalton C, Miller DH, Tofts PS, Barker GJ., Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times. Magn Reson Imaging 2002; 20: 721-731.
19. Plummer DL., Dispimage: a display and analysis tool for medical images. Riv Neuroradiol 1992; 5: 489-495.
20. Dam AM., Shrinkage of the brain during histological procedures with fixation in formaldehyde solutions of different concentrations. J Hirnforsch 1979; 20: 115-119.
21. Peterson JW, Bo L, Mork S, Chang A, Trapp BD., Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001; 50: 389-400.
22. Fox CH, Johnson FB, Whiting J, Roller PP., Formaldehyde fixation. J Histochem Cytochem 1985; 33: 845-853.
23. Hopwood D., Fixation and fixatives. In:, Bancroft JD, Stevens A, editors. Theory and practice of histological techniques, 4th ed. New York: Churchill Livingstone; 1996. p 23-45.
24. Yong-Hing CJ, Obenaus A, Stryker R, Tong K, Sarty GE., Magnetic resonance imaging and mathematical modeling of progressive formalin fixation of the human brain. Magn Reson Med 2005; 54: 324-332.
25. Geurts JJ, Bo L, Pouwels PJ, Castelijns JA, Polman CH, Barkhof F., Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. AJNR Am J Neuroradiol 2005; 26: 572-577.
26. Bo L, Vedeler CA, Nyland H, Trapp BD, Mork SJ., Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler 2003; 9: 323-331.
27. van Horssen J, Brink BP, de Vries HE, van der Valk P, Bo L., The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol 2007; 66: 321-328.
28. Bainbridge A, Schmierer K, Miller DH, Ordidge RJ, Yousry TA., High-field (7T) magnetic resonance imaging of post-mortem multiple sclerosis brain. In: Proc 12th Annual Meeting ISMRM, Kyoto; 2004:2316.
29. Albert M, Antel J, Bruck W, Stadelmann C., Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 2007; 17: 129-138.
30. Davies GR, Hadjiprocopis A, Altmann DR, et al. Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study. Mult Scler 2007; 13: 169-177.
31. Manfredonia F, Ciccarelli O, Khaleeli Z, etal. Normal-appearing brain T1 relaxation time predicts disability in early primary progressive multiple sclerosis. Arch Neurol 2007; 64: 411-415. (Pubitemid 46425697)
32. Nagara H, Inoue T, Koga T, Kitaguchi T, Tateishi J, Goto I., Formalin fixed brains are useful for magnetic resonance imaging (MRI) study. J Neurol Sci 1987; 81: 67-77.
33. Macchi G, Cioffi RP., An in vivo and post mortem MRI study in multiple sclerosis with pathological correlation. Ital J Neurol Sci 1992; 13 (Suppl 14): 97-103.
34. Sled JG, Pike GB., Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI. Magn Reson Med 2001; 46: 923-931.
35. Tofts PS, Steens SCA, van Buchem MA,. MT: magnetization transfer. In:, Tofts PS, editor. Quantitative MRI of the brain. Measuring changes caused by disease. Chichester, UK: John Wiley & Sons; 2003. p 257-98.
36. Bo L, Vedeler CA, Nyland HI, Trapp BD, Mork SJ., Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 2003; 62: 723-732.
37. Schmierer K, Parkes HG, So P-W, et al. High field (9.4T) magnetic resonance imaging of multiple sclerosis cortical grey matter lesions. Brain 2010; 133: 858-867.