Novel drug delivery system for lipophilic therapeutics of small molecule, peptide-based and protein drugs

Chirality

Volumn 22, Issue 1 E, 2010, Pages

  Hussain, Rohanah ^a   Siligardi, Giuliano ^a  

^a DIAMOND LIGHT SOURCE LTD   (United Kingdom)

Author keywords

albumin; bioavailability; biostability; drug delivery; formulation; lipopeptides

Indexed keywords

4 AMINOBUTYRIC ACID; ALKYL GROUP; FATTY ACID; HUMAN SERUM ALBUMIN; LIPOPEPTIDE; PROTEINASE;

CONFERENCE PAPER; CONJUGATION; DRUG DELIVERY SYSTEM; LIPOPHILICITY; MOLECULE; PRIORITY JOURNAL;

ANTI-INFECTIVE AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; LIPOPEPTIDES; SERUM ALBUMIN;

EID: 78349278816     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20897     Document Type: Conference Paper

References (11)

1. Scherrmann J.-M., Drug delivery to brain via the blood-brain barrier. Vasc Pharmacol 2002; 38: 349 354.
2. Kaparissides C, Alexandridou S, Kotti K, Chaitidou S,. Recent advances in novel drug delivery systems. J Nanotechnol Online 2006; 2: 1 11.
3. Hussain R,. Synthesis and structural elucidation of novel highly lipophilic CNS and antiviral drugs. PhD thesis, University of London, 1992.
4. Hussain R, Siligardi G,. Fat-free albumin as a novel drug delivery system international. J Pept Res Ther 2006; 12: 311 315.
5. Edelman AM, Blumenthal DK, Krebs EG,. Protein serine/threonine kinases. Ann Rev Biochem 1987; 56: 567 613.
6. House C, Kemp BE,. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 1987; 238: 1726 1728.
7. Hardie G,. Pseudosubstrates turn off protein kinases. Nature 1988; 335: 592 593.
8. Hussain R, Joannou C, Siligardi G,. Identification and characterization of novel lipophilic antimicrobial peptides derived from naturally occurring proteins. Int J Pept Res Ther 2006; 12: 269 273.
9. Peters T,. All about albumin. Academic Press: San Diego, CA, 1996.
10. Lee BL, Sachdeva M, Chambers HF,. Effect of protein binding of daptomycin on MIC and antibacterial activity. Antimicrob Agents Chemother 1991; 35: 2505 2508.
11. Makriyannis A, Guo J, Tian X,. Albumin enhances the diffusion of lipophilic drugs into the membrane. Life Sci 2005; 77: 1605 1611.