The safety of a mucosal vaccine using the C-terminal fragment of Clostridium perfringens enterotoxin

Pharmazie

Volumn 65, Issue 10, 2010, Pages 766-769

  Suzuki, H ^a   Kakutani, H ^a   Kondoh, Masuo ^a   Watari, A ^a   Yagi, Kiyohito ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; CLAUDIN 4; ENTEROTOXIN; OVALBUMIN; OVALBUMIN C TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN FUSION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; DOSE RESPONSE; DRUG SAFETY; EPITHELIUM CELL; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN;

ADMINISTRATION, INTRANASAL; ANIMALS; CLOSTRIDIUM INFECTIONS; CLOSTRIDIUM PERFRINGENS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENTEROTOXINS; FEMALE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; OVALBUMIN; PEPTIDE FRAGMENTS; TH1 CELLS; TH2 CELLS; VACCINES, SUBUNIT;

EID: 78349278030     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.0097     Document Type: Article

References (22)

1. Dhuria SV, Hanson LR, Frey WH (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99: 1654-1673.
2. Ebihara C, Kondoh M, Hasuike N, Harada M, Mizuguchi H, Horiguchi Y, Fujii M, Watanabe Y (2006) Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin. J Pharmacol Exp Ther 316: 255-260.
3. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 156: 1099-1111. (Pubitemid 34839858)
4. Furuse M, Tsukita S (2006) Claudins in occluding junctions of humans and flies. Trends Cell Biol 16: 181-188.
5. Ivanov AI, Nusrat A, Parkos CA (2004) Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell 15: 176-188. (Pubitemid 38044954)
6. Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi K (2010) Mucosal vaccination using claudin-4-targeting. Biomaterials 20: 5463-5471.
7. Katahira J, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N (1997) Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J Cell Biol 136: 1239-1247.
8. Kondoh M, Masuyama A, Takahashi A, Asano N, Mizuguchi H, Koizumi N, Fujii M, Hayakawa T, Horiguchi Y, Watanbe Y (2005) A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol Pharmacol 67: 749-756. (Pubitemid 40365322)
9. Kunisawa J, Nochi T, Kiyono H (2008) Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol 29: 505-513.
10. McClane BA (2001) Clostridium perfringens. In: Doyle MP, Beuchat LR, Montville TJ, editors. Food miclobiology: fundamentals and frontiers. Washington, DC: ASM Press: 352-372.
11. McClane BA, Chakrabarti G (2004) New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin. Anaerobe 10: 107-114.
12. McClane BA, Lyerly DM, Moncrief JS, Wilkins TD (2000) Enterotoxic clostridia: Clostridium perfringens type A and Clostridium difficile. In: Fischetti VA, Novick RP, Ferretti JJ, Portnoy DA, Rood JI, editors. Gram-positive pathogens. Washington, DC: ASM Press: 551-562.
13. Morita K, Furuse M, Fujimoto K, Tsukita S (1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 96: 511-516. (Pubitemid 29061239)
14. Neutra MR, Kozlowski PA (2006) Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 6: 148-158.
15. Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S (2003) Size-selective loosening of the blood-brain barrier in claudin-5- deficient mice. J Cell Biol 161: 653-660. (Pubitemid 36578587)
16. Rajapaksa TE, Stover-Hamer M, Fernandez X, Eckelhoefer HA, Lo DD (2010) Claudin 4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery. J Control Release 142: 196-205.
17. Saeki R, Kondoh M, Kakutani H, Tsunoda S, Mochizuki Y, Hamakubo T, Tsutsumi Y, Horiguchi Y, Yagi K (2009) A novel tumor-targeted therapy using a claudin-4-targeting molecule. Mol Pharmacol 76: 918-926.
18. Scheneeberger EE, Lynch RD (1992) Structure, function, and regulation of cellular tight junctions. Am J Physiol 262: L647-L661.
19. Sonoda N, Furuse M, Sasaki H, Yonemura S, Katahira J, Horiguchi Y, Tsukita S (1999) Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol 147: 195-204.
20. Tamagawa H, Takahashi I, Furuse M, Yoshitake-Kitano Y, Tsukita S, Ito T, Matsuda H, Kiyono H (2003) Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Lab Invest 83: 1045-1053. (Pubitemid 36899071)
21. Tsukita S, Furuse M, Itoh M (2001) Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2: 285-293.
22. Uchida H, Kondoh M, Hanada T, Takahashi A, Hamakubo T, Yagi K (2010) A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide. Biochem Pharmacol 79: 1437-1444.