Complicated but successful treatment of a patient with ataxia telangiectasia and pre-B-acute lymphoblastic leukemia

Klinische Padiatrie

Volumn 222, Issue 6, 2010, Pages 391-394

  Brummel, B ^a   Bernbeck, B ^a   Schneider, D T ^a  

^a KLINIKUM DORTMUND   (Germany)

Author keywords

Ataxia telangiectasia; Chromosomal breakage disorder; Immunodeficiency; Pre B acute lymphoblastic leukemia

Indexed keywords

AMPHOTERICIN B; ASPARAGINASE; CASPOFUNGIN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; ENOXAPARIN; IMMUNOGLOBULIN; LACTATE DEHYDROGENASE; MERCAPTOPURINE; METHOTREXATE; PREDNISONE; TRIMETHOPRIM; VINCRISTINE; VORICONAZOLE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADJUVANT THERAPY; ARTICLE; ATAXIA TELANGIECTASIA; B CELL LEUKEMIA; BLOOD CELL COUNT; BLOOD CULTURE; BONE MARROW BIOPSY; CANCER REGRESSION; CANDIDEMIA; CASE REPORT; CHILD; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG TOLERABILITY; ENCEPHALITIS; FEMALE; GASTROENTERITIS; HUMAN; LABORATORY TEST; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTOSIS; MEDICAL HISTORY; PICHIA ANOMALA; PNEUMOCYSTOSIS; SCHOOL CHILD; THROMBOCYTOPENIA; THROMBOSIS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ATAXIA TELANGIECTASIA; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REMISSION INDUCTION;

EID: 78349273589     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0030-1267151     Document Type: Article

References (18)

1. Chen C, Heusch A, Donner B, etal. Present risk of anthracycline or radiation-induced cardiac sequelae following therapy of malignancies in children and adolescents. Klin Padiatr 2009 221 162-166
2. Concannon P, Gatti RA. Diversity of ATM gene mutations detected in patients with ataxia-telangiectasia. Hum Mutat 1997 10 100-107
3. Datas received by personal correspondence with BFM ALL-2000 study centre.
4. Davies EG. Update on the management of the immunodeficiency in ataxia-telangiectasia. Expert Rev Clin Immunol 2009 5 565-575
5. Güngör T, Bühring I, Cremer R, etal. Pathogenesis, diagnosis, clinical and therapeutic aspects of ataxia telangiectasia. Klin Pädiatr 1997 209 328-335
6. Morgan JL, Holcomb TM, Morrissey RW. Radiation reaction in ataxiatelangiectasia. Am J Dis Child 1968 116 557-558
7. Möricke A, Zimmermann M, Reiter A, etal. Long-term results of 5 consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia 2010 24 265-284
8. Morrell D, Cromartie E, Swift M. Mortality and cancer incidence in 263 patients with ataxia-telangiectasia. J Natl Cancer Inst 1986 77 89-92
9. Niehues T, Schellong G, Dörffel W, etal. Immunodeficiency and Hodgkin's disease: treatment and outcome in the DAL HD78-90 and GPOH HD95 studies. Klin Padiatr 2003 215 315-320
10. Nowak-Wegrzyn A, Crawford TO, Winkelstein JA, etal. Immunodeficiency and infections in ataxia-telangiectasia. J Pediatr 2004 144 505-511
11. Pietrucha BM, Heropolitaska-Pliszka E, Wakuliska A, etal. Ataxia-telangiectasia with hyper-IgM and Wilms tumor: fatal reaction to irradiation. J Pediatr Hematol Oncol 2010 32 28-30
12. Pritchard J, Dandland MR, Breatnach FB, etal. The effects of radiation therapy for Hodgkin's disease in a child with ataxia teleangiectasia: a clinical, biological and pathologic study. Cancer 1982 50 877-886
13. Rübe CE, Fricke A, Wendorf J, etal. Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation. Int J Radiat Oncol Biol Phys 2010 76 1206-1213
14. Seidemann K, Tiemann M, Henze G, etal. Therapy for non-Hodgkin lymphoma in children with primary immunodeficiency: analysis of 19 patients from the BFM trials. Med Pediatr Oncol 1999 33 536-544
15. Sharma LM. B-cell acute lymphoblastic leukemia in a child with ataxia telangiectasia. Pediatr Hematol Oncol 2008 25 473-476
16. Taylor AMR, Byrd PJ. Molecular pathology of ataxia telangiectasia. J Clin Pathol 2005 58 1009-1015
17. Yamada Y, Inoue R, Fukaom T, etal. Ataxia telangiectasia associated with B-cell lymphoma: the effect of a half-dose of the drugs administered according to the acute lymphoblastic leukemia standard risk protocol. Pediatr Hematol Oncol 1998 15 425-429
18. Ziino O, Rondelli R. Acute lymphoblastic leukemia in children with associated genetic conditions other than Down's syndrome. The AIEOP experience. Haematologica 2006 91 139-140