Ethical issues surrounding fertility preservation in cancer patients

Clinical Obstetrics and Gynecology

Volumn 53, Issue 4, 2010, Pages 717-726

  Patrizio, Pasquale ^a   Caplan, Arthur L ^b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

artificial gametes; assent; ethics of fertility preservation; informed consent

Indexed keywords

ALKYLATING AGENT;

ARTIFICIAL INSEMINATION; CANCER PATIENT; CANCER SURVIVAL; CRYOPRESERVATION; EMBRYONAL TISSUE; EMBRYONIC STEM CELL; FEMALE STERILITY; FERTILITY; FERTILIZATION IN VITRO; FETUS OUTCOME; HUMAN; INFERTILITY THERAPY; INFORMED CONSENT; IONIZING RADIATION; LEGAL ASPECT; LIFE EXPECTANCY; MEDICAL DECISION MAKING; MEDICAL ETHICS; MEDICAL RESEARCH; OOCYTE DONATION; OOCYTE MATURATION; OOCYTE RETRIEVAL; OVARY FOLLICLE DEVELOPMENT; PRESERVATION; QUALITY OF LIFE; RADIATION INJURY; REVIEW; RISK BENEFIT ANALYSIS; SPERM PRESERVATION; STEM CELL TRANSPLANTATION; VITRIFICATION;

ANTINEOPLASTIC AGENTS; CRYOPRESERVATION; FEMALE; FERTILITY; HEALTH STATUS; HUMANS; INFERTILITY; INFORMED CONSENT; MALE; MEDICAL ONCOLOGY; NEOPLASMS; OOCYTES; PREGNANCY; PREGNANCY OUTCOME; RADIOTHERAPY; SEMEN PRESERVATION; STEM CELL RESEARCH;

EID: 78349272406     PISSN: 00099201     EISSN: None     Source Type: Journal    
DOI: 10.1097/GRF.0b013e3181f96a70     Document Type: Review

References (23)

1. Gosden RG. Fertility preservation-definition, history and prospect. Semin Reprod Med. 2009;27:433-437.
2. SEER Cancer Statistics Review, 1975- 2000, Bethesda, MD: National Cancer Institute. http://seer.cancer.gov. Accessed Feb 18, 2010.
3. Bromer JG, PatrizioP.Gynecologic management of fertility. In: Wingard JR, Gastineau D, Leather H, et al, eds. Hematopoietic Stem Cell Transplantation: A Clinician's Handbook. Bethesda, MD: AABB Press; 2009.
4. Patrizio P, Butt S, Caplan A. Ovarian tissue preservation and future fertility: emerging technologies and ethical considerations. JNCI. 2005;34:107-110.
5. Hirtz DG, Fitzsimmons LG. Regulatory and ethical issues in the conduct of clinical research involving children. Curr Opin Pediatr. 2002;14:669-675.
6. Grundy R, Larcher V, Gosden RG, et al. Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage and experimentation. Arch Dis Child. 2001;84:360-362.
7. Grundy R, Larcher V, Gosden RG, et al. Fertility preservation for children treated for cancer (1): scientific advances and research dilemmas. Arch Dis Child. 2001; 84:355-359.
8. Bahadur G. Ethics of testicular stem cells medicine. Hum Reprod. 2004;19:2702-2710.
9. Chian RC, Huang JY, Tan SL, et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online. 2008;16:608-610.
10. Noyes N, Porcu E, Borini A. Over 900 oocyte cryopreservation babies born with no apparent increase in congenital anomalies. Reprod Biomed Online. 2009; 18:769-776.
11. Wennerholm UB, Soderstrom-Anttila V, Bergh C, et al. Children born after cryo-preservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod. 2009;24:2158-2172.
12. Sutcliffe AG, Dsouza SW, Cadman J, et al. Minor congenital anomalies, major congenital malformations and development in children conceived from cryopre-served embryos. Hum Reprod. 1995;10: 3332-3337.
13. Donnez J, Dolmans MM, Demylle D, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405-1410.
14. Meirow D, Levron J, Eldar-Geva T, et al. Pregnancy after transplantation of cryo-preserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318-321.
15. Demeestere I, Simon P, Emiliani S, et al. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's disease. Oncologist. 2007;12: 1437-1442.
16. Andersen CY, Rosendahl M, Byskov AG, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23:2266-2272.
17. Sanchez-Serrano M, Crespo J, Mirabet V, et al. Twins born after transplantation of ovarian cortical tissue and oocyte vitrification. Fertil Steril. 2010;93:268, 11-13.
18. Silber SJ, DeRosa M, Pineda J, et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical vs. microvascular) and cryopreserva-tion. Hum Reprod. 2008;23:1531-1537.
19. Ernst E, Bergholdt S, Jørgensen JS, et al. The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue. Hum Reprod. 2010;25:1280-1281.
20. Silber SJ, Grudzinskas G, Gosden RG. Successful pregnancy after microsurgical transplantation of an intact ovary. N Engl J Med. 2008;359:2617-2618.
21. Mc Gee G, Patrizio P, Kuhn V, et al. The ethics of stem cell therapy. In: Patrizio P, GuelmanV,TuckerM,eds. A Color Atlas for Human Assisted Reproduction, Laboratory and Clinical Insights. Philadelphia: Lippincott Williams &Wilkins; 2003:297-309.
22. Caplan AL, Patrizio P. The beginning of the end of the embryo wars. Lancet. 2009;373:1074-1075.
23. Robertson JA. Procreative liberty, harm to offspring, and assisted reproduction. Am J Law Med. 2004;30:7-40.