Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains

Protein Science

Volumn 19, Issue 11, 2010, Pages 2110-2121

  Kelly, Libusha ^a,b   Fukushima, Hisayo ^a   Karchin, Rachel ^c   Gow, Jason M ^a   Chinn, Leslie W ^a   Pieper, Ursula ^a,b   Segal, Mark R ^d   Kroetz, Deanna L ^a   Sali, Andrej ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Johns Hopkins University   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ABC transporters; Genetic variation; Multidrug resistance; Structural modeling

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 4; NUCLEOTIDE; TENOFOVIR;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE TRANSPORT; CELL STRAIN HEK293; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; MUTATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; PROTEIN VARIANT; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS;

ADENINE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE ANNOTATION; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHOSPHONIC ACIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; SEQUENCE ALIGNMENT;

EID: 78349267919     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.491     Document Type: Article

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