Evolution of light scattering and redox balance in the rat lens after in vivo exposure to close-to-threshold dose ultraviolet radiation

Acta Ophthalmologica

Volumn 88, Issue 7, 2010, Pages 779-785

  Wang, Jing ^a,b   Löfgren, Stefan ^c   Dong, Xiuqin ^c   Galichanin, Konstantin ^b,c   Söderberg, Per G ^b  

^a SHANDONG UNIVERSITY   (China)

^b UPPSALA UNIVERSITY   (Sweden)

^c ST ERIK S EYE HOSPITAL   (Sweden)

Author keywords

cataract; forward light scattering; glutathione; lens; threshold; ultraviolet radiation

Indexed keywords

GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IN VIVO STUDY; LENS; LIGHT SCATTERING; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIATION EXPOSURE; RAT; ULTRAVIOLET RADIATION;

ANIMALS; CATARACT; DIFFERENTIAL THRESHOLD; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LENS, CRYSTALLINE; LIGHT; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; RADIATION INJURIES; RATS; RATS, SPRAGUE-DAWLEY; SCATTERING, RADIATION; SPECTROPHOTOMETRY; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 78349267596     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2009.01826.x     Document Type: Article

References (57)

1. Anderson EI, &, Spector A, (1978): The state of sulfhydryl groups in normal and cataractous human lens proteins. Exp Eye Res 26: 407 - 417.
2. Ayala MN, Michael R, &, Söderberg PG, (2000a): In vivo cataract after repeated exposure to ultraviolet radiation. Exp Eye Res 70: 451 - 456. (Pubitemid 30658887)
3. Ayala MN, Michael R, &, Söderberg PG, (2000b): Influence of exposure time for UV radiation-induced cataract. Invest Ophthalmol Vis Sci 41: 3539 - 3543.
4. Bernat R, &, Bombicki K, (1968): Changes in concentration of glutathione, ascorbic acid and amino acids with sulfhydryl groups in experimental cataracts. Acta Physiol Pol 19: 205 - 215.
5. Bochow TW, West SK, Azar A, Munoz B, Sommer A, &, Taylor HR, (1989): Ultraviolet light exposure and risk of posterior subcapsular cataracts. Arch Ophthalmol 107: 369 - 372.
6. Carlberg I, &, Mannervik B, (1985): Glutathione reductase. Meth Enzymol 113: 484 - 490.
7. Cruickshanks KJ, Klein BE, &, Klein R, (1992): Ultraviolet light exposure and lens opacities: the Beaver Dam Eye Study. Am J Public Health 82: 1658 - 1662.
8. Dische Z, (1956): Physiological chemistry of the eye; a review of papers published during 1955. AMA Arch Ophthalmol 56: 587 - 634.
9. Dong X, Ayala M, Löfgren S, &, Söderberg PG, (2003): Ultraviolet radiation-induced cataract: age and maximum acceptable dose. Invest Ophthalmol Vis Sci 44: 1150 - 1154.
10. Dong X, Söderberg PG, Ayala M, &, Löfgren S, (2005): The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation induced cataract. Ophthalmic Res 37: 197 - 201. (Pubitemid 41404760)
11. Dong X, Löfgren S, Marcelo A, &, Söderberg PG, (2007): Maximum tolerable dose for avoidance of cataract after repeated exposure to ultraviolet radiation in rats. Exp Eye Res 84: 200 - 208.
12. Ellman G, (1959): Tissue sulfhydryl groups. Arch Biochem Biophys 82: 70 - 77.
13. Ganea E, &, Harding JJ, (2006): Glutathione-related enzymes and the eye. Curr Eye Res 31: 1 - 11.
14. Giblin FJ, (2000): Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther 16: 121 - 135.
15. Harding JJ, (1970): Free and protein-bound glutathione in normal and cataractous human lenses. Biochem J 117: 957 - 960.
16. Hightower K, (1992): Mechanisms involved in cataract development following near-ultraviolet radiation of cultured lenses. Curr Eye Res 11: 679 - 689.
17. Li WC, (1996): Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract. Free Radic Biol Med 20: 301 - 311.
18. Löfgren S, &, Söderberg PG, (2001): Lens lactate dehydrogenase inactivation after UV-B irradiation: an in vivo measure of UVR-B penetration. Invest Ophthalmol Vis Sci 42: 1833 - 1836.
19. Löfgren S, Michael R, Ayala M, &, Söderberg PG, (1998): Influence of pupil size and eye pigmentation on ultraviolet radiation-induced cataract. ICER abstract. Exp Eye Res 67 (Suppl. 1): 140.
20. Löfgren S, Michael R, &, Soderberg PG, (2003): Impact of age and sex in ultraviolet radiation cataract in the rat. Invest Ophthalmol Vis Sci 44: 1629 - 1633.
21. Lou M, (2003): Redox regulation in the lens. Prog Retin Eye Res 22: 657 - 682.
22. Merriam J, Löfgren S, Michael R, Söderberg PG, Dillon J, Zheng L, &, Ayala M, (2000): An action spectrum for UV-B radiation in the rat lens. Invest Ophthalmol Vis Sci 41: 2642 - 2647.
23. Michael R, (2000): Development and repair of cataract induced by ultraviolet radiation. Ophthalmic Res 32 (Suppl. 1): 1 - 45.
24. Michael R, Söderberg PG, &, Chen E, (1996): Long-term development of lens opacities after exposure to ultraviolet radiation at 300nm. Ophthalmic Res 28: 209 - 218.
25. Michael R, Söderberg P, &, Chen E, (1998a): Dose response function for forward light scattering after in vivo exposure to ultraviolet radiation. Graefes Arch Clin Exp Ophthalmol 236: 625 - 629.
26. Michael R, Vrensen G, Van Marle J, Gan L, &, Söderberg PG, (1998b): Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation. Invest Ophthalmol Vis Sci 13: 2681 - 2687.
27. Mody VC Jr, Kakar MK, Elfving Å, Söderberg PG, &, Löfgren S, (2006): Ultraviolet radiation-B-induced cataract in albino rats; maximum tolerable dose and ascorbate consumption. Acta Ophthalmol Scand 84: 390 - 395.
28. Pirie A, (1971a): The effect of sunlight on proteins of the lens. In:, Bellows J, (ed.) Contemporary ophthalmology. Baltimore: Williams and Wilkins 494 - 501.
29. Pirie A, (1971b): Formation of N-formylkynurenine in proteins from lens and other sources by exposure to sunlight. Biochem J 125: 203 - 208.
30. Risa O, Saether O, Söderberg PG, Krane J, &, Midelfart A, (2004): Metabolic changes in rat lens after in vivo exposure to ultraviolet irradiation: measurements by high resolution MAS 1H NMR spectroscopy. Invest Ophthalmol Vis Sci 45: 1916 - 1921.
31. Risa O, Saether O, Kakar M, Mody V, Löfgren S, Söderberg PG, Krane J, &, Midelfart A, (2005): Time dependency of metabolic changes in rat lens after in vivo UVB irradiation analysed by HR-MAS 1H NMR spectroscopy. Exp Eye Res 81: 407 - 414.
32. Söderberg PG, (1988): Acute cataract in the rat after exposure to radiation in the 300nm wavelength region. A study of the macro-, micro- and ultrastructure. Acta Ophthalmol (Copenh) 66: 141 - 152.
33. Söderberg PG, (1989): Mass alteration in the lens after exposure to radiation in the 300nm wavelength region. Acta Ophthalmol (Copenh) 67: 633 - 644.
34. Söderberg PG, (1990a): Development of light dissemination in the rat lens after exposure to radiation in the 300nm wavelength region. Ophthalmic Res 22: 271 - 279.
35. Söderberg PG, (1990b): Experimental cataract induced by ultraviolet radiation. Acta Ophthalmol (Copenh) 68 (Suppl. 196): 1 - 77.
36. Söderberg PG, (1991): Na and K in the lens after exposure to radiation in the 300nm wave length region. J Photochem Photobiol B 8: 279 - 294.
37. Söderberg PG, Philipson BT, &, Lindström B, (1986): Unscheduled DNA synthesis in lens epithelium after in vivo exposure to UV radiation in the 300nm wavelength region. Acta Ophthalmol (Copenh) 64: 162 - 168.
38. Söderberg PG, Chen E, &, Lindström B, (1990): An objective and rapid method for the determination of light dissemination in the lens. Acta Ophthalmol (Copenh) 68: 44 - 52.
39. Söderberg PG, Löfgren S, Ayala M, Dong X, Kakar M, &, Mody V, (2002): Toxicity of ultraviolet radiation exposure to the lens expressed by maximum tolerable dose (MTD). Dev Ophthalmol 35: 70 - 75.
40. Söderberg PG, Michael R, &, Merriam JC, (2003): Maximum acceptable dose of ultraviolet radiation: a safety limit for cataract. Acta Ophthalmol Scand 81: 165 - 169.
41. Spector A, (1995): Oxidative stress-induced cataract: mechanism of action. [Review]. FASEB J 9: 1173 - 1182.
42. Sungchur M, Ternando MR, &, Lou MF, (2005): Induction of thioltransferase and thioredoxin/thioredoxin reductase systems in cultured porcine lenses under oxidative stress. Invest Ophthalmol Vis Sci 46: 3783 - 3790.
43. Takamura Y, Fatma N, Kubo E, &, Singh DP, (2006): Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75. Am J Pyhsiol Cell Pyhsiol 290: C554 - C566.
44. Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS, Abbey H, &, Emmett EA, (1988): Effect of ultraviolet radiation on cataract formation. N Engl J Med 319: 1429 - 1433.
45. Tessem M, Bathens T, Löfgren S, Mody V, Meyer L, Dong X, Söderberg PG, &, Midelfart A, (2006): Biological response in various compartments of the rat lens after in vivo exposure to UVR-B analyzed by HR-MAS 1H NMR spectroscopy. Invest Ophthalmol Vis Sci 47: 5404 - 5411.
46. Truscott RJ, &, Augusteyn RC, (1977): Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim Biophys Acta 492: 43 - 52.
47. Varma SD, Kumar S, &, Richards RD, (1979): Light-induced damage to ocular lens cation pump: prevention by vitamin C. Proc Natl Acad Sci 76: 3504 - 3506.
48. Varma SD, Chand D, Sharma YR, Kuck JF, &, Richards RD, (1984): Oxidative stress on lens and cataract formation: role of light and oxygen. Curr Eye Res 3: 35 - 57.
49. Wendel A, (1980): Enzymatic basis of detoxication. NY: Academic Press 1 333 - 334.
50. West SK, Duncan DD, Munoz B, Rubin GS, Fried LP, Bandeen-Roche K, &, Schein OD, (1998): Sunlight exposure and risk of lens opacities in a population-based study: the salisbury eye evaluation project. JAMA 280: 714 - 718.
51. Widmark J, (1901): ber den Einfluss des Lichtes auf die Linse.
52. Zar JH, (1999): Ch. 8.1 Testing for difference between two means. Biostatistical analysis. New Jersey: Prentice Hall 122 - 129.
53. Zigman S, (1971): Eye lens color: formation and function. Science 171: 807 - 809.
54. Zigman S, &, Vaughan T, (1974): Near-ultraviolet light effects on the lenses and retinas of mice. Invest Ophthalmol Vis Sci 13: 462 - 465.
55. Zigman S, Griess G, Yulo T, &, Schultz J, (1973a): Ocular protein alterations by near UV light. Exp Eye Res 15: 255 - 264.
56. Zigman S, Schultz J, &, Yulo T, (1973b): Possible roles of near UV light in the cataractous process. Exp Eye Res 15: 201 - 208.
57. Zigman S, Datiles M, &, Torczynski E, (1979): Sunlight and human cataracts. Invest Ophthalmol Vis Sci 18: 462 - 467.