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Volumn 1210, Issue 1, 2010, Pages 53-65

Primary trastuzumab resistance: New tricks for an old drug

Author keywords

Breast cancer; EGFR ErbB HER; Primary resistance; Targeted therapeutics; Trastuzumab herceptin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BORTEZOMIB; CETUXIMAB; DOCETAXEL; GEFITINIB; METFORMIN; NAVELBINE; PERTUZUMAB; RETINOIC ACID; TRASTUZUMAB; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HER2 PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

EID: 78349264613     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05782.x     Document Type: Article
Times cited : (62)

References (91)
  • 1
    • 76349103926 scopus 로고    scopus 로고
    • The HER2 testing conundrum
    • Allison, M. 2010. The HER2 testing conundrum. Nat. Biotechnol. 28: 117-119.
    • (2010) Nat. Biotechnol. , vol.28 , pp. 117-119
    • Allison, M.1
  • 2
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • Nahta, R., M.C. Hung & F.J. Esteva 2004. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 64: 2343-2346.
    • (2004) Cancer Res. , vol.64 , pp. 2343-2346
    • Nahta, R.1    Hung, M.C.2    Esteva, F.J.3
  • 3
    • 31444451572 scopus 로고    scopus 로고
    • Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism?
    • Arnould, L. et al 2006. Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br. J. Cancer 94: 259-267.
    • (2006) Br. J. Cancer , vol.94 , pp. 259-267
    • Arnould, L.1
  • 4
    • 0033118889 scopus 로고    scopus 로고
    • Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
    • Pegram, M. et al 1999. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18: 2241-2251.
    • (1999) Oncogene , vol.18 , pp. 2241-2251
    • Pegram, M.1
  • 5
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon, D.J. et al 2001. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344: 783-792.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1
  • 6
    • 0027524245 scopus 로고
    • The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage
    • Pupa, S.M. et al 1993. The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage. Oncogene 8: 2917-2923.
    • (1993) Oncogene , vol.8 , pp. 2917-2923
    • Pupa, S.M.1
  • 7
    • 0026071364 scopus 로고
    • The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3
    • Zabrecky, J.R. et al 1991. The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J. Biol. Chem. 266: 1716-1720.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1716-1720
    • Zabrecky, J.R.1
  • 8
    • 0033559210 scopus 로고    scopus 로고
    • Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells
    • Codony-Servat, J. et al 1999. Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. Cancer Res. 59: 1196-1201.
    • (1999) Cancer Res. , vol.59 , pp. 1196-1201
    • Codony-Servat, J.1
  • 9
    • 41949100690 scopus 로고    scopus 로고
    • Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer
    • Lafky, J.M. et al 2008. Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochim. Biophys. Acta 1785: 232-265.
    • (2008) Biochim. Biophys. Acta , vol.1785 , pp. 232-265
    • Lafky, J.M.1
  • 10
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
    • Molina, M.A. et al 2001. Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res. 61: 4744-4749.
    • (2001) Cancer Res. , vol.61 , pp. 4744-4749
    • Molina, M.A.1
  • 11
    • 0032532950 scopus 로고    scopus 로고
    • NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer
    • Christianson, T.A. et al 1998. NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer. Cancer Res. 58: 5123-5129.
    • (1998) Cancer Res. , vol.58 , pp. 5123-5129
    • Christianson, T.A.1
  • 12
    • 33746290773 scopus 로고    scopus 로고
    • Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation
    • Anido, J. et al 2006. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J. 25: 3234-3244.
    • (2006) EMBO J. , vol.25 , pp. 3234-3244
    • Anido, J.1
  • 13
    • 0022102126 scopus 로고
    • Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
    • Drebin, J.A. et al 1985. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell 41: 697-706.
    • (1985) Cell , vol.41 , pp. 697-706
    • Drebin, J.A.1
  • 14
    • 0028912598 scopus 로고
    • Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake
    • Hurwitz, E. et al 1995. Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc. Natl. Acad. Sci. USA 92: 3353-3357.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3353-3357
    • Hurwitz, E.1
  • 15
    • 0034234854 scopus 로고    scopus 로고
    • Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
    • Klapper, L.N. et al 2000. Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60: 3384-3388.
    • (2000) Cancer Res. , vol.60 , pp. 3384-3388
    • Klapper, L.N.1
  • 16
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
    • Baselga, J. & S.M. Swain 2009. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat. Rev. Cancer 9: 463-475.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 17
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector, N.L. & K.L. Blackwell 2009. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J. Clin. Oncol. 27: 5838-5847.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 19
    • 33947246109 scopus 로고    scopus 로고
    • Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer
    • Harris, L.N. et al 2007. Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin. Cancer Res. 13: 1198-1207.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1198-1207
    • Harris, L.N.1
  • 20
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff, A.C. et al 2007. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J. Clin. Oncol. 25: 118-145.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 118-145
    • Wolff, A.C.1
  • 21
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond, E.H. et al 2005. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 353: 1673-1684.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1673-1684
    • Romond, E.H.1
  • 22
    • 0032850779 scopus 로고    scopus 로고
    • The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor
    • Doherty, J.K. et al 1999. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc. Natl. Acad. Sci. USA 96: 10869-10874.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10869-10874
    • Doherty, J.K.1
  • 23
    • 0027468645 scopus 로고
    • A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells
    • Scott, G.K. et al 1993. A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells. Mol. Cell Biol. 13: 2247-2257.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 2247-2257
    • Scott, G.K.1
  • 24
    • 67649234062 scopus 로고    scopus 로고
    • A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis
    • Pedersen, K. et al 2009. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol. Cell Biol. 29: 3319-3331.
    • (2009) Mol. Cell Biol. , vol.29 , pp. 3319-3331
    • Pedersen, K.1
  • 25
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti, M. et al 2007. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J. Natl. Cancer Inst. 99: 628-638.
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 628-638
    • Scaltriti, M.1
  • 26
    • 0036187710 scopus 로고    scopus 로고
    • NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
    • Molina, M.A. et al 2002. NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin. Cancer Res. 8: 347-353.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 347-353
    • Molina, M.A.1
  • 27
    • 31544465529 scopus 로고    scopus 로고
    • p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer
    • Saez, R. et al 2006. p95HER-2 predicts worse outcome in patients with HER-2-positive breast cancer. Clin. Cancer Res. 12: 424-431.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 424-431
    • Saez, R.1
  • 28
    • 77955753644 scopus 로고    scopus 로고
    • Quantitation of p95HER2 in paraffin sections using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients
    • Sperinde, J. et al 2010. Quantitation of p95HER2 in paraffin sections using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients. Clin. Cancer Res. 16: 4226-4235.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4226-4235
    • Sperinde, J.1
  • 29
    • 0031564215 scopus 로고    scopus 로고
    • Soluble HER-2/neu neutralizes biologic effects of anti-HER-2/neu antibody on breast cancer cells in vitro
    • Brodowicz, T. et al 1997. Soluble HER-2/neu neutralizes biologic effects of anti-HER-2/neu antibody on breast cancer cells in vitro. Int. J. Cancer 73: 875-879.
    • (1997) Int. J. Cancer , vol.73 , pp. 875-879
    • Brodowicz, T.1
  • 30
    • 77956548639 scopus 로고    scopus 로고
    • Shed HER2 extracellular domain in HER2-mediated tumor growth and in Trastuzumab susceptibility
    • Ghedini, G.C. et al 2010. Shed HER2 extracellular domain in HER2-mediated tumor growth and in Trastuzumab susceptibility. J. Cell Physiol.
    • (2010) J. Cell Physiol.
    • Ghedini, G.C.1
  • 31
    • 53149107465 scopus 로고    scopus 로고
    • Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer
    • Ali, S.M. et al 2008. Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Cancer 113: 1294-1301.
    • (2008) Cancer , vol.113 , pp. 1294-1301
    • Ali, S.M.1
  • 32
    • 63749132329 scopus 로고    scopus 로고
    • Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer
    • Lennon, S. et al 2009. Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer. J. Clin. Oncol. 27: 1685-1693.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1685-1693
    • Lennon, S.1
  • 33
    • 77956182121 scopus 로고    scopus 로고
    • Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial
    • Witzel, I. et al 2010. Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial. Breast Cancer Res. Treat. 123: 437-445.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 437-445
    • Witzel, I.1
  • 34
    • 35948951183 scopus 로고    scopus 로고
    • Pathologic complete response to trastuzumab-based neoadjuvant therapy is related to the level of HER-2 amplification
    • Arnould, L. et al 2007. Pathologic complete response to trastuzumab-based neoadjuvant therapy is related to the level of HER-2 amplification. Clin. Cancer Res. 13: 6404-6409.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6404-6409
    • Arnould, L.1
  • 35
    • 35848945726 scopus 로고    scopus 로고
    • ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines
    • Ginestier, C. et al 2007. ERBB2 phosphorylation and trastuzumab sensitivity of breast cancer cell lines. Oncogene 26: 7163-7169.
    • (2007) Oncogene , vol.26 , pp. 7163-7169
    • Ginestier, C.1
  • 36
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein, I.B. 2002. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297: 63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 37
    • 65549090180 scopus 로고    scopus 로고
    • Trastuzumab-induced HER reprogramming in "resistant" breast carcinoma cells
    • In Press.
    • Narayan, M. et al 2009. Trastuzumab-induced HER reprogramming in "resistant" breast carcinoma cells. Cancer Res. In Press.
    • (2009) Cancer Res.
    • Narayan, M.1
  • 38
    • 77955559443 scopus 로고    scopus 로고
    • EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance
    • Dua, R. et al 2010. EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance. Breast Cancer Res. Treat. 122: 685-697.
    • (2010) Breast Cancer Res. Treat. , vol.122 , pp. 685-697
    • Dua, R.1
  • 39
    • 78049524084 scopus 로고    scopus 로고
    • HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer
    • In Press.
    • Yotsumoto, F. et al 2010. HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer. Int. J. Cancer. In Press.
    • (2010) Int. J. Cancer
    • Yotsumoto, F.1
  • 40
    • 77249164620 scopus 로고    scopus 로고
    • Immunohistochemical expression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy
    • Yonemori, K. et al 2010. Immunohistochemical expression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy. J. Surg. Oncol. 101: 222-227.
    • (2010) J. Surg. Oncol. , vol.101 , pp. 222-227
    • Yonemori, K.1
  • 41
    • 33746867442 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo
    • Jerome, L. et al 2006. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo. Cancer Res. 66: 7245-7252.
    • (2006) Cancer Res. , vol.66 , pp. 7245-7252
    • Jerome, L.1
  • 42
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu, Y. et al 2001. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J. Natl. Cancer Inst. 93: 1852-1857.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1852-1857
    • Lu, Y.1
  • 43
    • 70349966201 scopus 로고    scopus 로고
    • Gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma
    • Vegran, F. et al 2009. Gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma. Br. J. Cancer 101: 1357-1364.
    • (2009) Br. J. Cancer , vol.101 , pp. 1357-1364
    • Vegran, F.1
  • 44
    • 75149129568 scopus 로고    scopus 로고
    • Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy
    • Zhuang, G. et al 2010. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res. 70: 299-308.
    • (2010) Cancer Res. , vol.70 , pp. 299-308
    • Zhuang, G.1
  • 45
    • 52149124653 scopus 로고    scopus 로고
    • Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets
    • Martin, K.J. et al 2008. Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS ONE 3: e2994.
    • (2008) PLoS ONE , vol.3
    • Martin, K.J.1
  • 46
    • 33746894693 scopus 로고    scopus 로고
    • Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    • Fournier, M.V. et al 2006. Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res. 66: 7095-7102.
    • (2006) Cancer Res. , vol.66 , pp. 7095-7102
    • Fournier, M.V.1
  • 47
    • 51049090821 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab
    • Cavalloni, G. et al 2008. Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab. Anti-cancer Drugs 19: 689-696.
    • (2008) Anti-cancer Drugs , vol.19 , pp. 689-696
    • Cavalloni, G.1
  • 48
    • 23844475901 scopus 로고    scopus 로고
    • Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines
    • Mocanu, M.M. et al 2005. Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines. Cancer Lett. 227: 201-212.
    • (2005) Cancer Lett. , vol.227 , pp. 201-212
    • Mocanu, M.M.1
  • 49
    • 35448969823 scopus 로고    scopus 로고
    • Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer
    • Palyi-Krekk, Z. et al 2007. Hyaluronan-induced masking of ErbB2 and CD44-enhanced trastuzumab internalisation in trastuzumab resistant breast cancer. Eur. J. Cancer 43: 2423-2433.
    • (2007) Eur. J. Cancer , vol.43 , pp. 2423-2433
    • Palyi-Krekk, Z.1
  • 50
    • 0037142184 scopus 로고    scopus 로고
    • Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance
    • Price-Schiavi, S.A. et al 2002. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int. J. Cancer 99: 783-791.
    • (2002) Int. J. Cancer , vol.99 , pp. 783-791
    • Price-Schiavi, S.A.1
  • 51
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
    • Nagy, P. et al 2005. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 65: 473-482.
    • (2005) Cancer Res. , vol.65 , pp. 473-482
    • Nagy, P.1
  • 52
    • 70349895167 scopus 로고    scopus 로고
    • MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells
    • Fessler, S.P. et al 2009. MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Breast Cancer Res. Treat. 118: 113-124.
    • (2009) Breast Cancer Res. Treat. , vol.118 , pp. 113-124
    • Fessler, S.P.1
  • 53
    • 53749108489 scopus 로고    scopus 로고
    • MUC1* mediates the growth of human pluripotent stem cells
    • Hikita, S.T. et al 2008. MUC1* mediates the growth of human pluripotent stem cells. PLoS ONE 3: e3312.
    • (2008) PLoS ONE , vol.3
    • Hikita, S.T.1
  • 54
    • 44349182502 scopus 로고    scopus 로고
    • A minimal fragment of MUC1 mediates growth of cancer cells
    • Mahanta, S. et al 2008. A minimal fragment of MUC1 mediates growth of cancer cells. PLoS ONE 3: e2054.
    • (2008) PLoS ONE , vol.3
    • Mahanta, S.1
  • 55
    • 77949266488 scopus 로고    scopus 로고
    • Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
    • Kulkarni, S. et al 2009. Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer. Oncogene 29: 1339-1350.
    • (2009) Oncogene , vol.29 , pp. 1339-1350
    • Kulkarni, S.1
  • 56
    • 0036887581 scopus 로고    scopus 로고
    • Calpain: a role in cell transformation and migration
    • Carragher, N.O. & M.C. Frame 2002. Calpain: a role in cell transformation and migration. Int. J. Biochem. Cell Biol. 34: 1539-1543.
    • (2002) Int. J. Biochem. Cell Biol. , vol.34 , pp. 1539-1543
    • Carragher, N.O.1    Frame, M.C.2
  • 57
    • 1942431966 scopus 로고    scopus 로고
    • The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention
    • Citri, A., B.S. Kochupurakkal & Y. Yarden 2004. The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle 3: 51-60.
    • (2004) Cell Cycle , vol.3 , pp. 51-60
    • Citri, A.1    Kochupurakkal, B.S.2    Yarden, Y.3
  • 58
    • 75149123144 scopus 로고    scopus 로고
    • Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth
    • Chandarlapaty, S. et al 2010. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. Oncogene 29: 325-334.
    • (2010) Oncogene , vol.29 , pp. 325-334
    • Chandarlapaty, S.1
  • 59
    • 68849084042 scopus 로고    scopus 로고
    • Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib
    • Leow, C.C. et al 2009. Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib. Mol Cancer Ther. 8: 2131-2141.
    • (2009) Mol Cancer Ther. , vol.8 , pp. 2131-2141
    • Leow, C.C.1
  • 60
    • 74849117382 scopus 로고    scopus 로고
    • Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers
    • Hamel, S. et al 2010. Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers. Breast Cancer Res. Treat. 120: 47-57.
    • (2010) Breast Cancer Res. Treat. , vol.120 , pp. 47-57
    • Hamel, S.1
  • 61
    • 51649096911 scopus 로고    scopus 로고
    • Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells
    • Belkhiri, A. et al 2008. Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Clin. Cancer Res. 14: 4564-4571.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4564-4571
    • Belkhiri, A.1
  • 62
    • 77953873255 scopus 로고    scopus 로고
    • Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy
    • Yonemori, K. et al 2009. Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med. Oncol. 26: 344-349.
    • (2009) Med. Oncol. , vol.26 , pp. 344-349
    • Yonemori, K.1
  • 63
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata, Y. et al 2004. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6: 117-127.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1
  • 64
    • 84859899192 scopus 로고    scopus 로고
    • PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC). In Proceedings of the San Antonio Breast Cancer Symposium: Abstract 34. San Antonio, TX
    • Migliaccio, I. et al 2008. PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC). In Proceedings of the San Antonio Breast Cancer Symposium: Abstract 34. San Antonio, TX .
    • (2008)
    • Migliaccio, I.1
  • 65
    • 63549133332 scopus 로고    scopus 로고
    • EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
    • Gori, S. et al 2009. EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. Ann. Oncol. 20: 648-654.
    • (2009) Ann. Oncol. , vol.20 , pp. 648-654
    • Gori, S.1
  • 66
    • 77953411708 scopus 로고    scopus 로고
    • Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib
    • O'Brien, N.A. et al 2010. Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol. Cancer Ther. 9: 1489-1502.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1489-1502
    • O'Brien, N.A.1
  • 67
    • 77951884331 scopus 로고    scopus 로고
    • Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines
    • Kataoka, Y. et al 2010. Association between gain-of-function mutations in PIK3CA and resistance to HER2-targeted agents in HER2-amplified breast cancer cell lines. Ann. Oncol. 21: 255-262.
    • (2010) Ann. Oncol. , vol.21 , pp. 255-262
    • Kataoka, Y.1
  • 68
    • 77953359099 scopus 로고    scopus 로고
    • Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells
    • Koninki, K. et al 2010. Multiple molecular mechanisms underlying trastuzumab and lapatinib resistance in JIMT-1 breast cancer cells. Cancer Lett. 294: 211-219.
    • (2010) Cancer Lett. , vol.294 , pp. 211-219
    • Koninki, K.1
  • 69
    • 73149125324 scopus 로고    scopus 로고
    • Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines
    • Gu, L. et al 2009. Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines. Clin. Cancer Res. 15: 7196-7206.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7196-7206
    • Gu, L.1
  • 70
    • 77956362469 scopus 로고    scopus 로고
    • Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition
    • Cheng, Y. et al 2010. Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition. PLoS ONE 5: e9715.
    • (2010) PLoS ONE , vol.5
    • Cheng, Y.1
  • 71
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • Weigelt, B. et al 2009. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res. Treat. 122: 35-43.
    • (2009) Breast Cancer Res. Treat. , vol.122 , pp. 35-43
    • Weigelt, B.1
  • 72
    • 72249105509 scopus 로고    scopus 로고
    • Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer
    • Lesniak, D. et al 2009. Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer. Cancer Res. 69: 8620-8628.
    • (2009) Cancer Res. , vol.69 , pp. 8620-8628
    • Lesniak, D.1
  • 73
    • 77954155104 scopus 로고    scopus 로고
    • Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model
    • Delord, J.P. et al 2010. Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model. Br. J. Cancer 103: 61-72.
    • (2010) Br. J. Cancer , vol.103 , pp. 61-72
    • Delord, J.P.1
  • 74
    • 77950239573 scopus 로고    scopus 로고
    • HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation
    • Jain, A. et al 2010. HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation. Cancer Res. 70: 1989-1999.
    • (2010) Cancer Res. , vol.70 , pp. 1989-1999
    • Jain, A.1
  • 75
    • 77953464877 scopus 로고    scopus 로고
    • Trastuzumab sensitizes ovarian cancer cells to EGFR-targeted therapeutics
    • Wilken, J.A., K.T. Webster & N.J. Maihle 2010. Trastuzumab sensitizes ovarian cancer cells to EGFR-targeted therapeutics. J. Ovarian Res. 3: 7.
    • (2010) J. Ovarian Res. , vol.3 , pp. 7
    • Wilken, J.A.1    Webster, K.T.2    Maihle, N.J.3
  • 76
    • 0037043821 scopus 로고    scopus 로고
    • Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells
    • Tari, A.M. et al 2002. Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells. Oncogene 21: 5224-5232.
    • (2002) Oncogene , vol.21 , pp. 5224-5232
    • Tari, A.M.1
  • 77
    • 33846216907 scopus 로고    scopus 로고
    • Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner
    • Cardoso, F. et al 2006. Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2-positive breast cancer cells in a synergistic manner. Mol. Cancer Ther. 5: 3042-3051.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 3042-3051
    • Cardoso, F.1
  • 78
    • 72549108616 scopus 로고    scopus 로고
    • A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action
    • Damiano, V. et al 2009. A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action. Clin. Cancer Res. 15: 6921-6930.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6921-6930
    • Damiano, V.1
  • 79
    • 79958702901 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • In Press.
    • Vazquez-Martin, A. et al 2010. The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells. Breast Cancer Res. Treat. In Press.
    • (2010) Breast Cancer Res. Treat
    • Vazquez-Martin, A.1
  • 81
    • 77949323798 scopus 로고    scopus 로고
    • Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology
    • Martin-Castillo, B. et al 2010. Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology. Ann. Oncol. 21: 187-189.
    • (2010) Ann. Oncol. , vol.21 , pp. 187-189
    • Martin-Castillo, B.1
  • 82
    • 3242686392 scopus 로고    scopus 로고
    • Sensitization of breast cancer cells to radiation by trastuzumab
    • Liang, K. et al 2003. Sensitization of breast cancer cells to radiation by trastuzumab. Mol. Cancer Ther. 2: 1113-1120.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1113-1120
    • Liang, K.1
  • 83
    • 34447298092 scopus 로고    scopus 로고
    • Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance
    • Barok, M. et al 2007. Trastuzumab causes antibody-dependent cellular cytotoxicity-mediated growth inhibition of submacroscopic JIMT-1 breast cancer xenografts despite intrinsic drug resistance. Mol. Cancer Ther. 6: 2065-2072.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2065-2072
    • Barok, M.1
  • 84
    • 38349044364 scopus 로고    scopus 로고
    • Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor
    • Barok, M. et al 2008. Trastuzumab decreases the number of circulating and disseminated tumor cells despite trastuzumab resistance of the primary tumor. Cancer Lett. 260: 198-208.
    • (2008) Cancer Lett. , vol.260 , pp. 198-208
    • Barok, M.1
  • 85
    • 77953141926 scopus 로고    scopus 로고
    • Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer
    • Junttila, T.T. et al 2010. Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res. 70: 4481-4489.
    • (2010) Cancer Res. , vol.70 , pp. 4481-4489
    • Junttila, T.T.1
  • 86
    • 0036632965 scopus 로고    scopus 로고
    • Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways
    • Wu, K. et al 2002. Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. Mol. Cancer Ther. 1: 695-706.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 695-706
    • Wu, K.1
  • 87
    • 0037429728 scopus 로고    scopus 로고
    • Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm
    • Boerner, J.L., A. Danielsen & N.J. Maihle 2003. Ligand-independent oncogenic signaling by the epidermal growth factor receptor: v-ErbB as a paradigm. Exp. Cell Res. 284: 111-121.
    • (2003) Exp. Cell Res. , vol.284 , pp. 111-121
    • Boerner, J.L.1    Danielsen, A.2    Maihle, N.J.3
  • 88
    • 34249807047 scopus 로고    scopus 로고
    • Dysregulation of HER2/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells
    • Lin, J.H. et al 2007. Dysregulation of HER2/HER3 signaling axis in Epstein-Barr virus-infected breast carcinoma cells. J. Virol. 81: 5705-5713.
    • (2007) J. Virol. , vol.81 , pp. 5705-5713
    • Lin, J.H.1
  • 89
    • 33746131931 scopus 로고    scopus 로고
    • Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells
    • Chang, C.J. et al 2006. Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells. Eur. J. Clin. Invest. 36: 588-596.
    • (2006) Eur. J. Clin. Invest. , vol.36 , pp. 588-596
    • Chang, C.J.1
  • 90
    • 1342322682 scopus 로고    scopus 로고
    • Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines
    • Kauraniemi, P. et al 2004. Effects of Herceptin treatment on global gene expression patterns in HER2-amplified and nonamplified breast cancer cell lines. Oncogene 23: 1010-1013.
    • (2004) Oncogene , vol.23 , pp. 1010-1013
    • Kauraniemi, P.1
  • 91
    • 12344302247 scopus 로고    scopus 로고
    • Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer
    • Tanner, M. et al 2004. Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer. Mol. Cancer Ther. 3: 1585-1592.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1585-1592
    • Tanner, M.1


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