Evaluation of a QT nomogram for risk assessment after antidepressant overdose

British Journal of Clinical Pharmacology

Volumn 70, Issue 6, 2010, Pages 881-885

  Waring, W Stephen ^a   Graham, Ann ^a   Gray, Julie ^a   Wilson, Allen D ^a   Howell, Catherine ^a   Bateman, D Nicholas ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Clinical toxicology; Electrocardiogram; Mirtazapine; Poisoning; Venlafaxine

Indexed keywords

CITALOPRAM; MIRTAZAPINE; VENLAFAXINE;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG OVERDOSE; ELECTROCARDIOGRAM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOMOGRAM; PRIORITY JOURNAL; QT INTERVAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; TORSADE DES POINTES;

ADULT; ANTIDEPRESSIVE AGENTS; CITALOPRAM; CYCLOHEXANOLS; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; LONG QT SYNDROME; MALE; MIANSERIN; NOMOGRAMS; OVERDOSE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TORSADES DE POINTES;

EID: 78349260512     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03728.x     Document Type: Article

References (23)

1. Antzelevitch C. Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace 2007; 9 (Suppl. 4): 4-15.
2. Gupta A, Lawrence AT, Krishnan K, Kavinsky CJ, Trohman RG. Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 2007; 153: 891-9.
3. Kannankeril PJ, Roden DM. Drug-induced long QT and torsade de pointes: recent advances. Curr Opin Cardiol 2007; 22: 39-43.
4. Malik M, Hnatkova K, Sisakova M, Schmidt G. Subject-specific heart rate dependency of electrocardiographic QT, PQ, and QRS intervals. J Electrocardiol 2008; 41: 491-7.
5. Extramiana F, Maison-Blanche P, Cabanis MJ, Ortemann-Renon C, Beaufils P, Leenhardt A. Clinical assessment of drug-induced QT prolongation in association with heart rate changes. Clin Pharmacol Ther 2005; 77: 247-58.
6. Indik JH, Pearson EC, Fried K, Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval. Heart Rhythm 2006; 3: 1003-7.
7. Buckley NA, Chevalier S, Leditschke IA, O'Connell DL, Leitch J, Pond SM. The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose. Crit Care 2003; 7: R101-7.
8. Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007; 100: 609-15.
9. Fossa AA, Wisialowski T, Magnano A, Wolfgang E, Winslow R, Gorczyca W, Crimin K, Raunig DL. Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. J Pharmacol Exp Ther 2005; 312: 1-11.
10. Waring WS, Good AM, Bateman DN. Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit. Clin Toxicol 2007; 45: 45-50.
11. Howell C, Wilson AD, Waring WS. Cardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases. Br J Clin Pharmacol 2007; 64: 192-7.
12. Waring WS, Gray JA, Graham A. Predictive factors for generalized seizures after deliberate citalopram overdose. Br J Clin Pharmacol 2008; 66: 861-5.
13. Christie GA, Lucas C, Bateman DN, Waring WS. Redefining the ACE-inhibitor dose-response relationship: substantial blood pressure lowering after massive doses. Eur J Clin Pharmacol 2006; 62: 989-93.
14. Sala M, Coppa F, Cappucciati C, Brambilla P, D'Allio G, Caverzasi E, Barale F, De Ferrari GM. Antidepressants: their effects on cardiac channels, QT prolongation and torsade de pointes. Curr Opin Investig Drugs 2006; 7: 256-63.
15. De Gregorio C, Morabito G, Cerrito M, Dattilo G, Oreto G. Citalopram-induced long QT syndrome and torsade de pointes: role for concomitant therapies and illnesses. Int J Cardiol 2009; Jun 18. [Epub ahead of print] doi:10.1016/j.ijcard.2009.05.060.
16. Thanacoody HK, Waring WS. Toxins that affect the cardiovascular system. Clin Med 2008; 8: 92-5.
17. Aström-Lilja C, Odeberg JM, Ekman E, Hägg S. Drug-induced torsades de pointes: a review of the Swedish pharmacovigilance database. Pharmacoepidemiol Drug Saf 2008; 17: 587-92.
18. Isbister GK, Friberg LE, Stokes B, Buckley NA, Lee C, Gunja N, Brown SG, MacDonald E, Graudins A, Holdgate A, Duffull SB. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med 2007; 50: 593-600.
19. Letsas K, Korantzopoulos P, Pappas L, Evangelou D, Efremidis M, Kardaras F. QT interval prolongation associated with venlafaxine administration. Int J Cardiol 2006; 109: 116-7.
20. Wilson AD, Howell C, Waring WS. Venlafaxine ingestion is associated with rhabdomyolysis in adults: a case series. J Toxicol Sci 2007; 32: 97-101.
21. Tournier M, Molimard M, Abouelfath A, Cougnard A, Fourrier A, Haramburu F, Begaud B, Verdoux H. Accuracy of self-report and toxicological assays to detect substance misuse disorders in parasuicide patients. Acta Psychiatr Scand 2003; 108: 410-18.
22. Waring WS, Robinson ODG, Stephen AFL, Dow MA, Pettie JM. Does the patient history predict hepatotoxicity after acute paracetamol overdose. QJM 2008; 101: 121-5.
23. Balit CR, Isbister GK, Hackett LP, Whyte IM. Quetiapine poisoning: a case series. Ann Emerg Med 2003; 42: 751-8.