N-Acetylcysteine does not prevent renal dysfunction after off-pump coronary artery bypass surgery

European Journal of Anaesthesiology

Volumn 27, Issue 11, 2010, Pages 973-977

  Prasad, Apoorva ^a   Banakal, Sanjaykumar ^a   Muralidhar, Kanchi ^a  

^a Multispecialty Hospital Shaw Mazumdar Medical Centre   (India)

Author keywords

Cardiovascular; Complications; Failure; Kidney; Renal; Surgery

Indexed keywords

ACETYLCYSTEINE;

ADULT; AGED; ARTICLE; CHI SQUARE TEST; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; INCIDENCE; KIDNEY DYSFUNCTION; MALE; OFF PUMP CORONARY SURGERY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STUDENT T TEST;

ACETYLCYSTEINE; AGED; CORONARY ARTERY BYPASS, OFF-PUMP; FEMALE; FOLLOW-UP STUDIES; FREE RADICAL SCAVENGERS; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; RENAL INSUFFICIENCY; RISK FACTORS;

EID: 78349259317     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e3283383506     Document Type: Article

References (26)

1. Mangano CM, Diamondstone LS, Ramsay JG, et al. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group. Ann Intern Med 1998; 128:194-203.
2. Burns KEA, Chu MWA, Novick RJ, et al. Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk renal patients undergoing CABG surgery: a randomized controlled trial. JAMA 2005; 294:342-350.
3. Conlon P, Smith MS, White W, et al. Acute renal failure following cardiac surgery. Nephrol Dial Transplant 1999; 14:1158-1162.
4. Tepel M, van der Giet M, Schwarzfeld C, et al. Prevention of radiographiccontrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000; 343:180-184.
5. Shyu KG, Cheng JJ, Kuan P. Acetylcysteine protects against acute renal damage in patients with abnormal renal function undergoing a coronary procedure. J Am Coll Cardiol 2002; 40:1383-1388.
6. Kay J, Chow WH, Chan TM, et al. Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. JAMA 2003; 289:553-558.
7. Sladen RN. Renal physiology. In: Miller RD, editor. Miller's anesthesia, 6th ed. Philadelphia: Elsevier Churchill Livingstone; 2005. p. 788.
8. Pramodh K, Vani, Muralidhar K. Renal function following CABG: on-pump vs. off-pump. Indian J Thorac Cardiovasc Surg 2003; 19:169-173.
9. Zanardo G, Michielon P, Paccagnella A, et al. Acute renal failure in the patient undergoing cardiac operation: prevalence, mortality rate and main risk factors. J Thorac Cardiovasc Surg 1994; 107:1489-1495.
10. Gormley SM, McBride WT, Armstrong MA, et al. Plasma and urinary cytokine homeostasis and renal dysfunction during cardiac surgery. Anesthesiology 2000; 93:1210-1216.
11. MD CONSULT (E JOURNAL PORTAL). Drug Information Provided by Gold Standard Inc.; 2007. www.rguhs.ac.in/HELINET. [Access on November 2007]
12. Hynninen M, Niemi T, Poyhia R, et al. N-Acetylcysteine for prevention of kidney injury in abdominal aortic surgery: a randomized double-blind, placebo-controlled trial. Anesth Analg 2006; 102:1638-1645.
13. Ristikankare A, Kuitunen T, Kuitunen A, et al. Lack of renoprotective effect of i.v. N-acetylcysteine in patients with chronic renal failure undergoing cardiac surgery. Br J Anaesth 2006; 97:611-616.
14. Haase M, Fielitz AH, Bagshaw SM, et al. Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients. Crit Care Med 2007; 35:1324-1331.
15. Hamamsy IE, Stevens LM, Carrier M, et al. Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: a randomized, double blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg 2007; 133:7-12.
16. Wijeysundera DN, Beattie WS, Rao V, et al. N-Acetylcysteine for preventing acute kidney injury in cardiac surgery patients with preexisting moderate renal insufficiency. Can J Anesth 2007; 54:872-881.
17. Fischer UM, Tossios P, Mehlhorn U. Renal protection by radical scavenging in cardiac surgery patients. Curr Med Res Opin 2005; 21 :1161-1164.
18. Loef BG, Epema AH, Navis G, et al. Off-pump coronary revascularization attenuates transient renal damage compared with on-pump coronary revascularization. Chest 2002; 121 :1190-1194.
19. Schwann NM, Horrow JC, Strong MD III, et al. Does off-pump coronary artery bypass reduce the incidence of clinically evident renal dysfunction after multivessel myocardial revascularization? Anesth Analg 2004; 99:959-964.
20. Marenzi G, Assanelli E, Marana I, et al. N-Acetylcysteine and contrastinduced nephropathy in primary angioplasty. N Engl J Med 2006; 354:2773-2782.
21. Nitescu N, Ricksten SE, Marcussen N, et al. N-Acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. Nephrol Dial Transplant 2006; 21 :1240-1247.
22. Laisalmi-Kokki M, Pesonen M, Kokki H, et al. Potentially detrimental effects of N-acetylcysteine on renal function in knee arthroplasty. Free Radic Res 2009; 43:691-696.
23. Hoffmann U, Banas B, Fischereder M, et al. N-Acetylcysteine in the prevention of radiocontrast-induced nephropathy: clinical trials and end points. Kidney Blood Pressure Res 2004; 27:161-166.
24. Barr LF, Kolodner K. N-Acetylcysteine and fenoldopam protect the renal function of patients with chronic renal insufficiency undergoing cardiac surgery. Crit Care Med 2008; 36:1427-1435.
25. Wang F, Dupuis JY, Nathan H, Williams K. An analysis of the association between preoperative renal dysfunction and outcome in cardiac surgery: estimated creatinine clearance or plasma creatinine level as measures of renal function. Chest 2003; 124:1852-1862.
26. NoyezL, Plesiewicz I, Verheugt FW. Estimated creatinine clearance instead of plasma creatinine level as prognostic test for postoperative renal function in patients undergoing coronary artery bypass surgery. Eur J Cardiothorac Surg 2006; 29:461-465.