Leptin as an inflammatorymarker in dialysis patients;Diyaliz hastalarında i̇nflamatuvar belirteç olarak leptin

Turkiye Klinikleri Journal of Medical Sciences

Volumn 30, Issue 5, 2010, Pages 1482-1486

  Yildiz, Gürsel ^a   Yilmaz, Abdülkerim ^a   Nur, Naim ^a   Aydin, Hüseyin ^a   Kayataş, Mansur ^a  

^a CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

C reactive protein; Dialysis; Human; IL 6 protein; Leptin; Patients; Tumor necrosis factor alpha

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD LEVEL; BODY MASS; CHRONIC INFLAMMATION; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; KIDNEY FAILURE; LEPTIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE;

EID: 78349238573     PISSN: 13000292     EISSN: None     Source Type: Journal    
DOI: 10.5336/medsci.2009-14059     Document Type: Article

References (25)

1. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysio logic roles of interleukin-6 in human disease. Ann Intern Med 1998;128(2):127-37.
2. Foley RN, Parfrey PS, Sarmak MJ. Epidemiology of cardiovascular disease in chronic renal disease J Am Soc Nephrol 1998;9(12 Suppl):16-23.
3. Kaysen GA. The microlnflammatory state in uremia: Causes and potential consequences. J Am Soc Nephrol 2001;12(7):1549-57.
4. Stompór T, Pasowicz M, Sulłowicz W, Dembińska-Kieć A, Janda K, Wójcik K, et al. An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis. Am J Kidney Dis 2003;41(1):203-11.
5. Mendall MA, Patel P, Asante M, Balam L, Morris J, Strachan DP, et al. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart 1997;78(3):273-7.
6. Castel J, Gomez-Lechion M, David M, Fabra R, Trullenque R, Heinrich PC. Acute phase response of human hepatocyte: regulation of acute-phazse protein synthesis by interleukin-6. Hepatology 1990;12(5):1179-86.
7. Johansen KL, Mulligan K, Tal V, Schambelan M. Leptin, body composition and indices of malnutrition in patients on dialysis. J Am Soc Nephrol 1998;9(6):1080-4.
8. Sader S, Nian M, Liu P. Leptin: a novel link between obesity, diabetes, cardiovascular risk, and ventricular hypertrophy. Circulation 2003;108(6):644-6.
9. Kato A, Odamaki M, Maruyama Y, Hishida A. Association between circulating leptin and soluble receptors for tumor necrosis factor-alpha in hemodialysis patients. Clin Nephrol 2001;56(5):370-7.
10. Bolton CH, Downs LG, Victory JG, Dwight JF, Tomson CR, Mackness MI, Pinkney JH. Endothelial dysfunction in chronic renal failure: role of lipoprotein oxidation and pro-inflammatory cytokines. Nephrol Dial Transplant 2001; 16(6):1189-97.
11. Nordfors L, Lönnqvist F, Heimbürger O, Danielsson A, Schalling M, Stenvinkel P. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int 1998;54(4): 1267-75.
12. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in haemodialysis. Kidney Int 1999;55(2):648-58.
13. Docci D, Bilancioni R, Buscaroli A, Baldrati L, Capponcini C, Mengozzi S, et al. Elevated serum levels of C-reactive protein in haemodialysis patients. Nephron 1990;56(4): 364-7.
14. Bukan N, Sancak B, Paşaoǧlu H, Elbeg Ş, Ünal A, Erten Y. [Serum homocysteine, lipoprotein (a), tumor necrosis factor-alpha, total cholesterol and triglyceride levels in hemodialysis patients]. Turkiye Klinikleri J Med Sci 2004;24(5):435-9.
15. Boenisch O, Ehmke KD, Heddergott A, Naoum C, Frei U, Schindler R. C-reactive-protein and cytokine plasma levels in haemodialysis patients. J Nephrol 2002;15(5):547-51.
16. Widjaja A, Stratton IM, Horn R, Holman RR, Turner R, Brabant G. UKPDS20: Serum leptin, obesity, and serum insulin in type 2 diabetic subjects. J Clin Endocrinol Metab 1997;82(2): 654-7.
17. Zumbach MS, Boehme MWJ, Wahl P, Stremmel W, Ziegler R, Nawroth PP. Tumor necrosis factor increases serum leptin levels in humans. J Clin End Met 1997;82(12):4080-2.
18. Hilkens MG, Netea MG, Van der Meer JW, Koolen MI. Leptin and proinflammatory cytokines in patients undergoing peritoneal dialysis. Eur J Clin Invest 2003;33(6):525-6.
19. Pecoits-Filho R, Nordfors L, Heimburger O, Lindholm B, Anderstam B, Marchiewska A, et al. Soluble leptin receptors and serum leptin in end-stage renal disease. relationship with inflammation and body composition. Eur J Clin Invest 2002;32(11):811-7.
20. Don BR, Rosales LM, Levine NW, Mitch W, Kaysen GA. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int 2001;59(3):1114-20.
21. Shamsuzzaman ASM, Winnicki M, Wolk R, Svatikova A, Phillips BG, Davison DE, et al. Independent association between serum leptin and C-reactive protei n in healthy humans. Circulation 2004;109:2181-5.
22. Wallace AM, McMahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, et al. Serum leptin and the risk cardiovascular disease in the west of Scotland cornary prevention study (WOS-COPS). Circulation 2001;104(25):3052-6.
23. Sharma K, Considine RV, Michael B, Dunn SR, Weisberg LS, Kurnik BR, et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997;51(6):1980-5.
24. Ostlund RE, Yang JW, Klein S, Gingerich R. Relation between serum leptin concentration and body fat, gender, diet, age and metabolic covariates. J Clin Endocrinol Metab 1996;81 (11):3909-13.
25. Wanner C, Zimmermann J, Schwedler S, Metzger T. Inflammation and cardiovascular risk in dialysis patients. Kidney Int 2002;61(Suppl 80):99-102.