Challenges facing quantification of rat locomotion along beams of varying widths

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 224, Issue 11, 2010, Pages 1257-1265

  Madete, J K ^a   Klein, A ^b   Fuller, A ^b   Trueman, R C ^b   Rosser, A E ^a,b   Dunnett, S B ^b   Holt, C A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

6 OHDA; gait analysis; motion capture; motor behaviour; Parkinson's disease

Indexed keywords

6-HYDROXYDOPAMINE (6-OHDA); 6-OHDA; ANIMAL MODEL; GAIT PARAMETERS; HUMAN MOTION ANALYSIS; MOTION CAPTURE; MOTION CAPTURE SYSTEM; PARKINSON'S DISEASE; RAT MODEL; SIMPLE APPROACH; TRANSLATIONAL MEDICINE; MOTOR BEHAVIOURS;

ANIMALS; DISEASES; GAIT ANALYSIS; BEHAVIORAL RESEARCH; MEDICINE; NEURODEGENERATIVE DISEASES; RATS;

BEHAVIORAL RESEARCH; DISEASES;

OXIDOPAMINE;

ANIMAL; ARTICLE; DISEASE MODEL; FIDUCIAL MARKER; GAIT; IMAGE PROCESSING; INJURY; LOCOMOTION; MALE; METHODOLOGY; PARKINSON DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SUBSTANTIA NIGRA; VIDEORECORDING;

ANIMALS; DISEASE MODELS, ANIMAL; FIDUCIAL MARKERS; GAIT; IMAGE PROCESSING, COMPUTER-ASSISTED; LOCOMOTION; MALE; OXIDOPAMINE; PARKINSON DISEASE; RATS; SUBSTANTIA NIGRA; VIDEO RECORDING;

EID: 78349237704     PISSN: 09544119     EISSN: None     Source Type: Journal    
DOI: 10.1243/09544119JEIM779     Document Type: Article

References (47)

1. Garnier, C., Falempin, M., and Canu, M. H. A 3D analysis of fore- and hindlimb motion during locomotion: Comparison of overground and ladder walking in rats. Behav. Brain Res., 2008, 186(1), 57-65.
2. Brooks, S. P. and Dunnett, S. B. Tests to assess motor phenotype in mice: A user's guide. Nat. Rev. Neurosci., 2009, 10(7), 519-529.
3. Cenci, M. A., Whishaw, I. Q., and Schallert, T. Animal models of neurological deficits: How relevant is the rat? Nat. Rev. Neurosci., 2002, 3(7), 574-579.
4. Metz, G. A. and Whishaw, I. Q. The ladder rung walking task: A scoring system and its practical application. J. Vis. Exp., 2009 (28), 1204. doi: 10.3791/1204.
5. Whishaw, I. Q., Li, K., Whishaw, P. A., Gorny, B., and Metz, G. A. Distinct forelimb and hind limb stepping impairments in unilateral dopaminedepleted rats: Use of the rotorod as a method for the qualitative analysis of skilled walking. J. Neurosci. Methods, 2003, 126(1), 13-23.
6. Canu, M. H. and Garnier, C. A 3D analysis of foreand hindlimb motion during overground and ladder walking: Comparison of control and unloaded rats. Expl. Neurol., 2009, 218(1), 98-108.
7. Allbutt, H. N. and Henderson, J. M. Use of the narrow beam test in the rat, 6-hydroxydopamine model of Parkinson's disease. J. Neurosci. Methods, 2007, 159(2), 195-202.
8. Canu, M. H., Garnier, C., Lepoutre, F. X., and Falempin, M. A 3D analysis of hindlimb motion during treadmill locomotion in rats after a 14-day episode of simulated microgravity. Behav. Brain Res., 2005, 157(2), 309-321.
9. Marcuzzo, S., Dutra, M. F., Stigger, F., do Nascimento, P. S., Ilha, J., Kalil-Gaspar, P. I., and Achaval, M. Beneficial effects of treadmill training in a cerebral palsy-like rodent model: Walking pattern and soleus quantitative histology. Brain Res., 2008, 1222, 129-140.
10. Pereira, J. E., Cabrita, A. M., Filipe, V. M., Bulas- Cruz, J., Couto, P. A., Melo-Pinto, P., Costa, L. M., Geuna, S., Mauricio, A. C., and Varejao, A. S. A comparison analysis of hindlimb kinematics during overground and treadmill locomotion in rats. Behav. Brain Res., 2006, 172(2), 212-218.
11. Coulthard, P., Pleuvry, B. J., Brewster, M., Wilson, K. L., and Macfarlane, T. V. Gait analysis as an objective measure in a chronic pain model. J. Neurosci. Methods, 2002, 116(2), 197-213.
12. Brown, M. and Taylor, J. Prehabilitation and rehabilitation for attenuating hindlimb unweighting effects on skeletal muscle and gait in adult and old rats. Arch. Phys. Med. Rehabil., 2005, 86(12), 2261-2269.
13. Fan, L. W., Tien, L. T., Mitchell, H. J., Rhodes, P. G., and Cai, Z. Alpha-phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharide. Eur. J. Neurosci., 2008, 27(6), 1475-1484.
14. Klein, A., Wessolleck, J., Papazoglou, A., Metz, G. A., and Nikkhah, G. Walking pattern analysis after unilateral 6-OHDA lesion and transplantation of foetal dopaminergic progenitor cells in rats. Behav. Brain Res., 2009, 199(2), 317-325.
15. Wang, H., Spinner, R. J., Sorenson, E. J., and Windebank, A. J. Measurement of forelimb function by digital video motion analysis in rat nerve transection models. J. Peripher. Nerv. Syst., 2008, 13(1), 92-102.
16. Boyd, B. S., Puttlitz, C., Noble-Haeusslein, L. J., John, C. M., Trivedi, A., and Topp, K. S. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J. Neurosci. Res., 2007, 85(10), 2272-2283.
17. Deumens, R., Jaken, R. J., Marcus, M. A., and Joosten, E. A. The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection. J. Neurosci. Methods, 2007, 164(1), 120-130.
18. Koopmans, G. C., Deumens, R., Brook, G., Gerver, J., Honig, W. M., Hamers, F. P., and Joosten, E. A. Strain and locomotor speed affect over-ground locomotion in intact rats. Physiol Behav., 2007, 92(5), 993-1001.
19. Hamers, F. P., Lankhorst, A. J., van Laar, T. J., Veldhuis, W. B., and Gispen, W. H. Automated quantitative gait analysis during overground locomotion in the rat: Its application to spinal cord contusion and transection injuries. J. Neurotrauma, 2001, 18(2), 187-201.
20. Vrinten, D. H. and Hamers, F. F. 'CatWalk' automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing. Pain, 2003, 102(1-2), 203-209.
21. Fu, S. C., Chan, K. M., Chan, L. S., Fong, D. T., and Lui, P. Y. The use of motion analysis to measure pain-related behaviour in a rat model of degenerative tendon injuries. J. Neurosci. Methods, 2009, 179(2), 309-318.
22. Varejao, A. S., Cabrita, A. M., Meek, M. F., Bulas- Cruz, J., Gabriel, R. C., Filipe, V. M., Melo-Pinto, P., and Winter, D. A. Motion of the foot and ankle during the stance phase in rats. Muscle Nerve, 2002, 26(5), 630-635.
23. Gorska, T., Zmyslowski, W., and Majczynski, H. Overground locomotion in intact rats: Interlimb coordination, support patterns and support phases duration. Acta Neurobiol. Exp. (Wars.), 1999, 59(2), 131-144.
24. Jones, L., Beynon, M. J., Holt, C. A., and Roy, S. An application of the Dempster-Shafer theory of evidence to the classification of knee function and detection of improvement due to total knee replacement surgery. J. Biomech., 2006, 39(13), 2512-2520.
25. Jones, L., Holt, C. A., and Beynon, M. J. Reduction, classification and ranking of motion analysis data: An application to osteoarthritic and normal knee function data. Comput. Methods Biomech. Biomed. Engng, 2008, 11(1), 31-40.
26. Narayanan, U. G. The role of gait analysis in the orthopaedic management of ambulatory cerebral palsy. Curr. Opin. Pediatr., 2007, 19(1), 38-43.
27. Watelain, E., Dujardin, F., Babier, F., Dubois, D., and Allard, P. Pelvic and lower limb compensatory actions of subjects in an early stage of hip osteoarthritis. Arch. Phys. Med. Rehabil., 2001, 82(12), 1705-1711.
28. Metz, G. A., Dietz, V., Schwab, M. E., and van de, M. H. The effects of unilateral pyramidal tract section on hindlimb motor performance in the rat. Behav. Brain Res., 1998, 96(1-2), 37-46.
29. Couto, P. A., Filipe, V. M., Magalhaes, L. G., Pereira, J. E., Costa, L. M., Melo-Pinto, P., Bulas- Cruz, J., Mauricio, A. C., Geuna, S., and Varejao, A. S. A comparison of two-dimensional and threedimensional techniques for the determination of hindlimb kinematics during treadmill locomotion in rats following spinal cord injury. J. Neurosci. Methods, 2008, 173(2), 193-200.
30. Moreau, C., Defebvre, L., Bleuse, S., Blatt, J. L., Duhamel, A., Bloem, B. R., Destee, A., and Krystkowiak, P. Externally provoked freezing of gait in open runways in advanced Parkinson's disease results from motor and mental collapse. J. Neural Transm., 2008, 115(10), 1431-1436.
31. Schaafsma, J. D., Giladi, N., Balash, Y., Bartels, A. L., Gurevich, T., and Hausdorff, J. M. Gait dynamics in Parkinson's disease: Relationship to Parkinsonian features, falls and response to levodopa. J. Neurol. Sci., 2003, 212(1-2), 47-53.
32. Plotnik, M., Giladi, N., and Hausdorff, J. M. Bilateral coordination of walking and freezing of gait in Parkinson's disease. Eur. J. Neurosci., 2008, 27(8), 1999-2006.
33. Woollacott, M. and Shumway-Cook, A. Attention and the control of posture and gait: A review of an emerging area of research. Gait Posture, 2002, 16(1), 1-14.
34. Latt, M. D., Menz, H. B., Fung, V. S., and Lord, S. R. Acceleration patterns of the head and pelvis during gait in older people with Parkinson's disease: A comparison of fallers and nonfallers. J. Gerontol. A Biol. Sci. Med. Sci., 2009, 64(6), 700-706.
35. Metz, G. A., Tse, A., Ballermann, M., Smith, L. K., and Fouad, K. The unilateral 6-OHDA rat model of Parkinson's disease revisited: An electromyographic and behavioural analysis. Eur. J. Neurosci., 2005, 22(3), 735-744.
36. Brown, L. A., de Bruin, N., Doan, J. B., Suchowersky, O., and Hu, B. Novel challenges to gait in Parkinson's disease: The effect of concurrent music in single- and dual-task contexts. Arch. Phys. Med. Rehabil., 2009, 90(9), 1578-1583.
37. Dowd, E. and Dunnett, S. B. Comparison of 6- hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats. Behav. Brain Res., 2005, 159(1), 153-161.
38. Sinclair, S. R., Fawcett, J. W., and Dunnett, S. B. Delayed implantation of nigral grafts improves survival of dopamine neurones and rate of functional recovery. Neuroreport, 1999, 10(6), 1263-1267.
39. Kirik, D., Rosenblad, C., and Bjorklund, A. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat. Exp. Neurol., 1998, 152(2), 259-277.
40. Ungerstedt, U. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur. J Pharmacol., 1968, 5(1), 107-110.
41. Miklyaeva, E. I., Martens, D. J., and Whishaw, I. Q. Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats. Brain Res., 1995, 681(1-2), 23-40.
42. Duhamel, A., Bourriez, J. L., Devos, P., Krystkowiak, P., Destee, A., Derambure, P., and Defebvre, L. Statistical tools for clinical gait analysis. Gait Posture, 2004, 20(2), 204-212.
43. Whishaw, I. Q., Suchowersky, O., Davis, L., Sarna, J., Metz, G. A., and Pellis, S. M. Impairment of pronation, supination, and body co-ordination in reach-to-grasp tasks in human Parkinson's disease (PD) reveals homology to deficits in animal models. Behav. Brain Res., 2002, 133(2), 165-176.
44. Lundblad, M., Andersson, M., Winkler, C., Kirik, D., Wierup, N., and Cenci, M. A. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease. Eur. J. Neurosci., 2002, 15(1), 120-132.
45. Pinna, A., Pontis, S., Borsini, F., and Morelli, M. Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. Synapse, 2007, 61(8), 606-614.
46. Miklyaeva, E. I., Castaneda, E., and Whishaw, I. Q. Skilled reaching deficits in unilateral dopaminedepleted rats: Impairments in movement and posture and compensatory adjustments. J. Neurosci., 1994, 14(11 Pt 2), 7148-7158.
47. Klein, A. and Schmidt, W. J. Catalepsy intensifies context-dependently irrespective of whether it is induced by intermittent or chronic dopamine deficiency. Behav. Pharmacol., 2003, 14(1), 49-53.