Quantificational and statistical analysis of the differences in centrosomal features of untreated lung cancer cells and normal cells

Analytical and Quantitative Cytology and Histology

Volumn 32, Issue 5, 2010, Pages 280-290

  Song, Dansheng ^a   Fedorenko, Inna ^a   Pensky, Marianna ^a,b   Qian, Wei ^a,c   Tockman, Melvyn S ^a,d   Zhukov, Tatyana A ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

^c 500 W University Avenue   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Centrosome; Kolmogorov Smirnov test; Lung cancer; Statistical analysis; t test

Indexed keywords

ARTICLE; CANCER CELL; CELL MATURATION; CELL SHAPE; CELL STRUCTURE; CENTROSOME; CONTROLLED STUDY; CORRELATION ANALYSIS; EARLY DIAGNOSIS; HUMAN; HUMAN CELL; IMAGE ANALYSIS; KOLMOGOROV SMIRNOV TEST; LUNG ALVEOLUS CELL; LUNG CANCER; NULL HYPOTHESIS; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; STUDENT T TEST; EPITHELIUM CELL; LUNG; LUNG TUMOR;

CENTROSOME; EPITHELIAL CELLS; HUMANS; LUNG; LUNG NEOPLASMS; PROGNOSIS;

EID: 78349236528     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Nigg EA: Centrosome aberrations: Cause or consequence of cancer progression? Nature Rev Cancer 2002;2:815-825
2. Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M, Fukasawa K, Sugimura H: Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol 2008;216:365-374
3. Fukasawa K: Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007;7:911-924
4. Bourke E, Dodson H, Andreas Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG: DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep 2007;8:603-609 (Pubitemid 47214716)
5. Saunders W: Centrosomal amplification and spindle multipolarity in cancer cells (review). Semin Cancer Biol 2005;15:25-32
6. Lentini L, Amato A, Schillaci T, Di Leonardo A: Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype. BMC Cancer 2007;7:212
7. Landen CN Jr, Lin YG, Immaneni A, Deavers MT, Merritt WM, Spannuth WA, Bodurka DC, Gershenson DM, Brinkley WR, Sood AK: Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients. Clin Cancer Res 2007;13:4098-4104
8. Jung CK, Jung JH, Lee KY, Kang CS, Kim M, Ko YH, Oh CS: Centrosome abnormalities in non-small cell lung cancer: Correlations with DNA aneuploidy and expression of cell cycle regulatory proteins. Pathol Res Pract 2007;203:839-847
9. Koutsami MK, Tsantoulis PK, Kouloukoussa M, Apostolopoulou K, Pateras IS, Spartinou Z, Drougou A, Evangelou K, Kittas C, Bartkova J, Bartek J, Gorgoulis VG: Centrosome abnormalities are frequently observed in non-small-cell lung cancer and are associated with aneuploidy and cyclin E overexpression. J Pathol 2006;209:512-521
10. Berrut J-P, Trefethen LN: Barycentric Lagrange interpolation. SIAM Rev 2004;46:501-517
11. Yin P-Y: Maximum entropy-based optimal threshold selection using deterministic reinforcement learning with controlled randomization. Signal Processing 2002;82:993-1006
12. Addison PS: Fractals and Chaos: An Illustrated Course. London, Institute of Physics Publishing, 1997
13. Michalak K, Kwánicka H: Correlation-based feature selection strategy in classification problems. Int J Appl Math Comput Sci 2006;16:503-511 (Pubitemid 46117651)
14. Terriberry TB, Joshi SC, Gerig G: Hypothesis testing with nonlinear shape models. Inform Process Med Imaging 2005;3565:15-26
15. Kozmann G, Green LS, Lux RL: Nonparametric identification of discriminative information in body surface maps. IEEE Trans Biomed Eng 1991;38:1061-1068
16. Gustafson LM, Gleich LL, Fukasawa K, Chadwell J, Miller MA, Stambrook PJ, Gluckman JL: Centrosome hyperamplification in head and neck squamous cell carcinoma: A potential phenotypic marker of tumor aggressiveness. Laryngoscope 2000;110:1798-1801
17. Pihan GA, Wallace J, Zhou Y, Doxsey SJ: Centrosome abnormalities and chromosome instability occur together in preinvasive carcinomas. Cancer Res 2003;63:1398-1404
18. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, Whitehead CM, Reynolds C, Salisbury JL: Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002;99:1978-1983
19. Sato N, Mizumoto K, Nakamura M, Maehara N, Minamishima YA, Nishio S, Nagai E, Tanaka M: Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells. Cancer Genet Cytogenet 2001;126:13-19 (Pubitemid 32421565)
20. D'Assoro AB, Busby R, Acu ID, Quatraro C, Reinholz MM, Farrugia DJ, Schroeder MA, Allen C, Stivala F, Galanis E, Salisbury JL: Impaired p53 function leads to centrosome amplification, acquired ERalpha phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts. Oncogene 2008;27:3901-3911
21. Salisbury JL, D́ssoro AB, Lingle WL: Centrosome amplification and the origin of chromosomal instability in breast cancer [review]. J Mammary Gland Biol Neoplasia 2004;9:275-283
22. Hontz AE, Li SA, Lingle WL, Negron V, Bruzek A, Salisbury JL, Li J: Aurora A and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: Implications for chromosomal instability, aneuploidy, and neoplasia. Cancer Res 2007;67:2957-2963
23. Piel M, Nordberg J, Euteneuer U, Bornens M: Centrosome-dependent exit of cytokinesis in animal cells. Science 2001;291:1550-1553
24. Shono M, Sato N, Mizumoto K, Maehara N, Nakamura M, Nagai E, Tanaka M: Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice. Lab Invest 2001;81:945-952
25. Hsu LC, Kapali M, Deloia JA, Gallion HH: Centrosome abnormalities in ovarian cancer. Int J Cancer 2005;113:746-751
26. Kawamura K, Moriyama M, Shiba N, Ozaki M, Tanaka T, Nojima T, Fujikawa-Yamamoto K, Ikeda R, Suzuki K: Centrosome hyperamplification and chromosomal instability in bladder cancer. Eur Urol 2003;43:505-515
27. Pihan GA, Purohit A, Wallace J, Malhotra R, Liotta L, Doxsey SJ: Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res 2001;61:2212-2219
28. Guo HQ, Gao M, Ma J, Xiao T, Zhao LL, Gao Y, Pan QJ: Analysis of the cellular centrosome in fine-needle aspirations of the breast. Breast Cancer Res 2007;9:R48