Diabetes Mellitus in Elkhounds Is Associated with Diestrus and Pregnancy

Journal of Veterinary Internal Medicine

Volumn 24, Issue 6, 2010, Pages 1322-1328

  Fall, T ^a,b   Hedhammar, A ^a   Wallberg, A ^a   Fall, N ^a   Ahlgren, K M ^c   Hamlin, H H ^a   Lindblad Toh, K ^d   Andersson, G ^a   Kampe O ^c  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Growth hormone; Ovariohysterectomy; Progesterone

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; CASE CONTROL STUDY; DIESTRUS; DOG; DOG DISEASE; FEMALE; METABOLISM; PREGNANCY; PREGNANCY DIABETES MELLITUS; RISK FACTOR; STATISTICAL MODEL;

ANIMALS; CASE-CONTROL STUDIES; DIABETES, GESTATIONAL; DIESTRUS; DOG DISEASES; DOGS; FEMALE; LOGISTIC MODELS; PREGNANCY; RISK FACTORS;

CANIS FAMILIARIS;

EID: 78349234970     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2010.0630.x     Document Type: Article

References (44)

1. Campbell EA. The treatment and control of diabetes in the dog. Aust Vet J 1958;34:222-225.
2. Wilkinson JS. Spontaneous diabetes mellitus. Vet Rec 1960;72:548-555.
3. Eigenmann JE, Eigenmann RY, Rijnberk A, et al. Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly. Acta Endocrinol (Copenh) 1983;104:167-176.
4. Fall T, Hamlin HH, Hedhammar A, et al. Diabetes mellitus in a population of 180, 000 insured dogs: Incidence, survival, and breed distribution. J Vet Intern Med 2007;21:1209-1216.
5. Eigenmann JE, Rijnberk A. Influence of medroxyprogesterone acetate (Provera) on plasma growth hormone levels and on carbohydrate metabolism. I. Studies in the ovariohysterectomized bitch. Acta Endocrinol (Copenh) 1981;98:599-602.
6. Egenvall A, Hedhammar A, Bonnett BN, et al. Survey of the Swedish dog population: Age, gender, breed, location and enrollment in animal insurance. Acta Vet Scand 1999;40:231-240.
7. Fall T, Johansson Kreuger S, Juberget A, et al. Gestational diabetes mellitus in 13 dogs. J Vet Intern Med 2008;22:1296-1300.
8. Fall T, Holm B, Karlsson A, et al. Glucagon stimulation test for estimating endogenous insulin secretion in dogs. Vet Rec 2008;163:266-270.
9. Beijerink NJ, Bhatti SF, Okkens AC, et al. Adenohypophyseal function in bitches treated with medroxyprogesterone acetate. Domest Anim Endocrinol 2007;32:63-78.
10. Favier RP, Mol JA, Kooistra HS, et al. Large body size in the dog is associated with transient GH excess at a young age. J Endocrinol 2001;170:479-484.
11. Arata S, Hashizume C, Kikusui T, et al. Sequences of canine glutamate decarboxylase (GAD) 1 and GAD2 genes, and variation of their genetic polymorphisms among five dog breeds. J Vet Med Sci 2008;70:1107-1110.
12. Alimohammadi M, Bjorklund P, Hallgren A, et al. Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med 2008;358:1018-1028.
13. Concannon PW, Hansel W, Visek WJ. The ovarian cycle of the bitch: Plasma estrogen, LH and progesterone. Biol Reprod 1975;13:112-121.
14. Foster SJ. Diabetes mellitus-a study of the disease in the dog and cat in Kent. J Small Anim Pract 1975;16:295-315.
15. Egenvall A, Hagman R, Bonnett BN, et al. Breed risk of pyometra in insured dogs in Sweden. J Vet Intern Med 2001;15:530-538.
16. McLane MP, Tomasik TW, Law WR, et al. Hepatic insulin resistance during canine sepsis. Circ Shock 1991;33:207-215.
17. Park K, Steffes M, Lee DH, et al. Association of inflammation with worsening HOMA-insulin resistance. Diabetologia 2009;52:2337-2344.
18. Krook L, Larsson S, Rooney JR. The interrelationship of diabetes mellitus, obesity, and pyometra in the dog. Am J Vet Res 1960;21:120-127.
19. Kleinberg DL, Wood TL, Furth PA, et al. Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev 2009;30:51-74.
20. Mol JA, Van Garderen E, Selman PJ, et al. Growth hormone mRNA in mammary gland tumors of dogs and cats. J Clin Invest 1995;95:2028-2034.
21. Montelongo A, Lasuncion MA, Pallardo LF, et al. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 1992;41:1651-1659.
22. Barbour LA, Shao J, Qiao L, et al. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol 2002;186:512-517.
23. Ryan EA, Enns L. Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab 1988;67:341-347.
24. Kirwan JP, Hauguel-De Mouzon S, Lepercq J, et al. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 2002;51:2207-2213.
25. Catalano PM, Thomas AJ, Huston LP, et al. Effect of maternal metabolism on fetal growth and body composition. Diabetes Care 1998;21 (Suppl 2):B85-B90.
26. Igout A, Scippo ML, Frankenne F, et al. Cloning and nucleotide sequence of placental hGH-V cDNA. Arch Int Physiol Biochim 1988;96:63-67.
27. Selman PJ, Mol JA, Rutteman GR, et al. Progestin-induced growth hormone excess in the dog originates in the mammary gland. Endocrinology 1994;134:287-292.
28. Kooistra HS, Den Hertog E, Okkens AC, et al. Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus in Beagle bitches. J Reprod Fertil 2000;119:217-222.
29. McCann JP, Altszuler N, Hampshire J, et al. Growth hormone, insulin, glucose, cortisol, luteinizing hormone, and diabetes in Beagle bitches treated with medroxyprogesterone acetate. Acta Endocrinol (Copenh) 1987;116:73-80.
30. Lernmark A, Baekkeskov S. Islet cell antibodies-theoretical and practical implications. Diabetologia 1981;21:431-435.
31. Davison LJ, Weenink SM, Christie MR, et al. Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Vet Immunol Immunopathol 2008;126:83-90.
32. Polonsky KS, Pugh W, Jaspan JB, et al. C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog. J Clin Invest 1984;74:1821-1829.
33. Faber OK, Binder C. C-peptide response to glucagon. A test for the residual beta-cell function in diabetes mellitus. Diabetes 1977;26:605-610.
34. Montgomery TM, Nelson RW, Feldman EC, et al. Basal and glucagon-stimulated plasma C-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism. J Vet Intern Med 1996;10:116-122.
35. Imamura T, Koffler M, Helderman JH, et al. Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia. Diabetes 1988;37:600-609.
36. Van Goethem B, Schaefers-Okkens A, Kirpensteijn J. Making a rational choice between ovariectomy and ovariohysterectomy in the dog: A discussion of the benefits of either technique. Vet Surg 2006;35:136-143.
37. Okkens AC, Kooistra HS, Nickel RF. Comparison of long-term effects of ovariectomy versus ovariohysterectomy in bitches. J Reprod Fertil Suppl 1997;51:227-231.
38. Bhatti SF, Duchateau L, Okkens AC, et al. Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology 2006;66:797-803.
39. Hod M, Merlob P, Friedman S, et al. Gestational diabetes mellitus. A survey of perinatal complications in the 1980s. Diabetes 1991;40 (Suppl 2):74-78.
40. Casey BM, Lucas MJ, McIntire DD, et al. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol 1997;90:869-873.
41. Savitz DA, Janevic TM, Engel SM, et al. Ethnicity and gestational diabetes in New York City, 1995-2003. Br J Gynecol 2008;115:969-978.
42. Retnakaran R, Connelly PW, Sermer M, et al. The impact of family history of diabetes on risk factors for gestational diabetes. Clin Endocrinol (Oxf) 2007;67:754-760.
43. Solomon CG, Willett WC, Carey VJ, et al. A prospective study of pregravid determinants of gestational diabetes mellitus. JAMA 1997;278:1078-1083.
44. Karlsson EK, Baranowska I, Wade CM, et al. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 2007;39:1321-1328.