Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency

Neurology

Volumn 75, Issue 18, 2010, Pages 1617-1622

  Worthington, V ^a   Killestein, J ^b   Eikelenboom, M J ^b   Teunissen, C E ^b   Barkhof, F ^b   Polman, C H ^b   Uitdehaag, B M J ^b   Petzold, A ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON;

ADULT; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHRONIC VEIN INSUFFICIENCY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; IRON STORAGE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENINGOENCEPHALITIS; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; PRIORITY JOURNAL; SIDEROSIS; SUBARACHNOID HEMORRHAGE;

EID: 78349234284     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181fb449e     Document Type: Article

References (19)

1. Singh AV, Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 2009;29:1867-1878.
2. Keir G, Tasdemir N, Thompson EJ. Cerebrospinal fluid ferritin in brain necrosis: evidence for local synthesis. Clin Chim Acta 1993;216:153-166.
3. Campbell DR, Skikne BS, Cook JD. Cerebrospinal fluid ferritin levels in screening for meningism. Arch Neurol 1986;43:1257-1260.
4. Petzold A, Eikelenboom MJ, Gveric D, et al. Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Brain 2002;125:1462-1473.
5. Polman CH, Reingold SC, Edan G, et al. Diagnostic crite-ria for multiple sclerosis: 2005 revisions to the "McDonald Criteria."Ann Neurol 2005;58:840-846.
6. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey Na-tional Multiple Sclerosis Society (USA) Advisory Commit-tee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-911.
7. Petzold A, Sharpe LT, Keir G. Spectrophotometry for ce-rebrospinal fluid pigment analysis. Neurocrit Care 2006;4: 153-162.
8. Cruickshank A, Auld P, Beetham R, et al. Revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage. Ann Clin Bio-chem 2008;45:238-244.
9. Teunissen CE, Petzold A, Bennett JL, et al. A consensus protocol for the standardization ofcerebrospinal fluid col-lection and biobanking. Neurology 2009;73:1914-1922.
10. Kurtzke JF. Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neu-rology 1983;33:1444-1452.
11. Kalkers NF, Bergers E, Castelijns JA, et al. Optimizing the association between disability and biological markers in MS. Neurology 2001;57:1253-1258.
12. Lazeron RH, Boringa JB, Schouten M, et al. Brain atro-phy and lesion load as explaining parameters for cogni-tive impairment in multiple sclerosis. Mult Scler 2005; 11:524-531.
13. Suzuki H, Muramatsu M, Tanaka K, et al. Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal sub-arachnoid hemorrhage. J Neurol2006;253:1170-1176.
14. Petzold A, Worthington V, Pritchard C, et al. The longitu-dinal profile of bilirubin and ferritin in the cerebrospinal fluid following a subarachnoid hemorrhage: diagnostic im-plications. Neurocrit Care 2009;11:398-402.
15. Petzold A, Worthington V, Kerr ME, et al. Cerebrospinal fluid ferritin levels, a sensitive diagnostic test in delayed presenting subarachnoid haemorrhage. J Stroke Cerebro-vasc Dis (in press 2010).
16. Ikeda T, Noto D, Noguchi-Shinohara M, et al. CSF tau protein is a useful marker for effective treatment ofsuper-ficial siderosis of the central nervous system: two case re-ports. Clin Neurol Neurosurg 2010;112:62-64.
17. Zappone E, Bellotti V, Cazzola M, et al. Cerebrospinal fluid ferritin in human disease. Haematologica 1986;71: 103-107.
18. Petzold A, Altintas A, Andreoni L, et al. Neurofilament ELISAvalidation. J Immunol Methods 2010;352:23-31.
19. Connor JR, Menzies SL. Relationship of iron to oligoden-drocytes and myelination. Glia 1996;17:83-93