Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats

Microvascular Research

Volumn 80, Issue 3, 2010, Pages 484-490

  Hiller, Karl Heinz ^b   Ruile, Philipp ^a   Kraus, Günter ^a   Bauer, Wolfgang R ^a   Waller, Christiane ^c  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b Research Center Magnetic Resonance Bavaria (MRB)   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ACE inhibition; Angiogenesis; Coronary stenosis; Microcirculation

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; QUINAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VOLUME; CAPILLARY DENSITY; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE BLOOD FLOW; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEMODYNAMICS; IMAGE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REST; SPIN LABELING; SYSTEMIC VASCULAR RESISTANCE; SYSTOLE; TISSUE SPECIFICITY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CORONARY CIRCULATION; CORONARY STENOSIS; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING, CINE; MICROCIRCULATION; MYOCARDIAL PERFUSION IMAGING; MYOCARDIUM; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; TETRAHYDROISOQUINOLINES; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 78249286479     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.05.007     Document Type: Article

References (44)

1. Bauer W.R., et al. Magnetization exchange in capillaries by microcirculation affects diffusion-controlled spin-relaxation: a model which describes the effect of perfusion on relaxation enhancement by intravascular contrast agents. Magn. Res. Med. 1996, 35:43-55.
2. 1 after slice selective spin inversion in the isolated cardioplegic rat heart: measurement of a lower bound of intracapillary-extravascular water exchange rate. Magn. Res. Med. 1997, 38:917-923.
3. Belle V., et al. In vivo quantitative mapping of cardiac perfusion in rats using a noninvasive MR spin-labeling method. J. Magn. Reson. Imaging 1998, 8:1240-1245.
4. Buikema H., et al. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J. Cardiovasc. Pharmacol. 1997, 29:684-691.
5. Buus N.H., et al. Myocardial perfusion during long-term angiotensin-converting enzyme inhibition or beta-blockade in patients with essential hypertension. Hypertension 2004, 44:465-470.
6. Capasso J.M., et al. Ventricular remodeling induced by acute nonocclusive constriction of coronary artery in rats. Am. J. Physiol. Heart Circ. Physiol. 1989, 257:H1983-H1993.
7. Clozel J.P., et al. Effects of chronic ACE inhibition on cardiac hypertrophy and coronary vascular reserve in spontaneously hypertensive rats with developed hypertension. J. Hypertens. 1989, 7:267-275.
8. Dietz R., et al. Improvement of cardiac function by angiotensin converting enzyme inhibition. Sites of action. Circulation 1993, 87(supp):IV108-IV116.
9. Ertl G., et al. Influence of angiotensin-converting enzyme inhibition on cardiac function in myocardial infarction. Am. J. Cardiol. 1990, 65:70G-73G.
10. Fabre J.-E., et al. Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo. Circulation 1999, 99:3043-3049.
11. Fabris B., et al. Inhibition of tissue angiotensin-converting enzyme (ACE) in plasma and tissue. J. Cardiovasc. Pharmacol. 1990, 15:6-13.
12. Fallavollita J.A., et al. Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ. Res. 2003, 92:48-55.
13. Gohlke P., et al. Vascular and cardiac protection by ramipril in spontaneously hypertensive rats: prevention versus regression study. Br. J. Clin. Pract. Suppl. 1996, 99:1873-1879.
14. 2 and chemical-shift imaging. Magn. Res. Med. 1990, 13:77-89.
15. Haleen S.J., et al. Effects of quinapril, a new angiotensin converting enzyme inhibitor, on left ventricular failure and survival in the cardiomyopathic hamster. Hemodynamic, morphological, and biochemical correlates. Circ. Res. 1991, 68:1203-1312.
16. Heusch G. Hibernating myocardium. Physiol. Rev. 1998, 78:1055-1085.
17. Higgins C.B., et al. Functional evaluation of the heart with magnetic resonance imaging. Magn. Reson. Med. 1988, 6:121-139.
18. Jayaweera A.R., et al. Role of capillaries in determining CBF reserve: new insights using myocardial contrast echocardiography. Am. J. Physiol. 1999, 277:H2363-H2372.
19. Jerosch-Herold M., et al. Analysis of myocardial perfusion MRI. J. Magn. Res. Imaging 2004, 19:758-770.
20. Kahler E., et al. Perfusion-corrected mapping of cardiac regional blood volume in rats in vivo. Magn. Res. Med. 1999, 42:500-506.
21. Kahler E., et al. Quantitative regional blood volume studies in rat myocardium in vivo. Magn. Res. Med. 1998, 40:517-525.
22. Kobara M., et al. Effects of ACE inhibition on myocardial apoptosis in an ischemia-reperfusion rat heart model. J. Cardiovasc. Pharmacol. 2003, 41:880-889.
23. Köhler S., et al. Time-resolved flow measurement in the isolated rat heart: characterization of left coronary artery stenosis. Magn. Res. Med. 2003, 50:449-452.
24. Kowallik P., et al. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 1991, 83:974-982.
25. Langendorff O. Untersuchung am überlebenden Säugetierherzen. Pflügers Arch. 1895, 61:291-332.
26. Lund-Johansen P., Omvik P. Cardiac effects of ACE inhibition. J. Cardiovasc. Pharmacol. 1993, 22(Suppl 1):36-40.
27. Matsunaga T., et al. Ischemia-induced coronary collateral growth is dependent on vascular endothelial growth factor and nitric oxide. Circulation 2000, 102:3098-3103.
28. Nahrendorf M., et al. Chronic coronary artery stenosis induces impaired function of remote myocardium: MRI and spectroscopy study in rat. Am. J. Physiol. Heart Circ. Physiol 2003, 285:H2712-H2721.
29. Numaguchi K., et al. Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats. Hypertension 1995, 26:957-962.
30. Ogan M.D., et al. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: preparation and characterization. Invest. Radiol. 1987, 22:665-671.
31. Olivetti G., et al. Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 1993, 21:362-370.
32. Pfeffer M.A., et al. Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Circulation 1985, 72:406-412.
33. Rerkpattanapipat P., et al. Assessment of cardiac function with MR imaging. Mag. Res. Imaging Clin. N. Am. 2003, 11:67-80.
34. Sakuma H., Higgins C.B. Magnetic resonance measurement of coronary blood flow. Acta Paediatr. Suppl. 2004, 93:80-85.
35. Sato H., et al. Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker. Am. J. Physiol. 2003, 10:H359-H368.
36. Strauer B.E., et al. ACE-inhibitors and coronary microcirculation. Basic Res. Cardiol. 1993, 88(supp 1):97-106.
37. Tarazi R.C., Zanchetti A. Prospectives for angiotensin converting enzyme inhibition in heart diseases. J. Hypertens. Suppl. 1985, 3:99-103.
38. Volpert O.V., et al. Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats. J. Clin. Invest. 1996, 98:671-679.
39. Waller C., et al. Resting perfusion in viable myocardium distal to chronic coronary stenosis is reduced: characterization by magnetic resonance imaging and radiolabeled microspheres in the rat. Am. J. Physiol. 2005, 288:H 2588-H 2593.
40. Waller C., et al. Microvascular adaptation to coronary stenosis in the rat heart in vivo: a serial magnetic resonance imaging study. Microvasc. Res. 2003, 48:123-127.
41. Waller C., et al. Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique. Radiology 2000, 215:189-197.
42. Wang D.H., Prewitt R.L. Captopril reduces aortic and microvascular growth in hypertensive and normotensive rats. Hypertension 1990, 15:68-77.
43. Weber K.T., Brilla C.G. Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 1991, 83:1849-1865.
44. Ziche M., et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 1994, 94:2036-2044.