Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat

Mammalian Genome

Volumn 21, Issue 9-10, 2010, Pages 499-508

  Finlay, Clare ^a   Argoud, Karène ^a   Wilder, Steven P ^a   Ouali, Fetta ^b   Ktorza, Alain ^c   Kaisaki, Pamela J ^a   Gauguier, Dominique ^a,d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CNRS   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

^d CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; GROWTH FACTOR; GROWTH HORMONE; PROLACTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN NORWAY RAT; CELL STRUCTURE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 17; CHROMOSOME 6; CHROMOSOME MAP; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DIABETOGENESIS; DUODENUM; FEMALE; GENETIC VARIABILITY; GOTO KAKIZAKI RAT; GROWTH HORMONE BLOOD LEVEL; HISTOPATHOLOGY; HORMONE DETERMINATION; LINKAGE ANALYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PHENOTYPE; PROLACTIN BLOOD LEVEL; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS MAPPING; RAT; SPLEEN;

ANIMALS; BLOOD GLUCOSE; CHROMOSOME MAPPING; CORTICOSTERONE; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; GENETIC LINKAGE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GROWTH HORMONE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; PANCREAS; PHENOTYPE; PROLACTIN; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED BN;

RATTUS; RATTUS NORVEGICUS;

EID: 78249275236     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-010-9285-3     Document Type: Article

References (43)

1. RC Andrews BR Walker 1999 Glucocorticoids and insulin resistance: old hormones, new targets Clin Sci (Lond) 96 513 523 1:CAS:528:DyaK1MXjslSrsLk%3D 10.1042/CS19980388 (Pubitemid 29237902)
2. K Argoud SP Wilder MA McAteer MT Bihoreau F Ouali PY Woon RH Wallis A Ktorza D Gauguier 2006 Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats Diabetologia 49 2679 2688 1:CAS:528:DC%2BD28XhtFOqsrrF 10.1007/s00125-006-0396-z 16983556
3. N Ben-Jonathan ER Hugo TD Brandebourg CR LaPensee 2006 Focus on prolactin as a metabolic hormone Trends Endocrinol Metab 17 110 116 1:CAS:528: DC%2BD28XjtFOlsLs%3D 10.1016/j.tem.2006.02.005 16517173
4. MT Bihoreau D Gauguier N Kato G Hyne K Lindpaintner JP Rapp MR James GM Lathrop 1997 A linkage map of the rat genome derived from three F2 crosses Genome Res 7 434 440 1:CAS:528:DyaK2sXjtFWltbk%3D 9149940
5. M Bilusic A Bataillard MR Tschannen L Gao NE Barreto M Vincent T Wang HJ Jacob J Sassard AE Kwitek 2004 Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat Hypertension 44 695 701 1:CAS:528:DC%2BD2cXovVCgt78%3D 10.1161/01.HYP. 0000144542.57306.5e 15452030 (Pubitemid 39440015)
6. TC Brelje DW Scharp PE Lacy L Ogren F Talamantes M Robertson HG Friesen RL Sorenson 1993 Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy Endocrinology 132 879 887 1:CAS:528:DyaK3sXitVGlsLk%3D 10.1210/en.132.2.879 8425500 (Pubitemid 23056153)
7. TC Brelje LE Stout NV Bhagroo RL Sorenson 2004 Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of langerhans Endocrinology 145 4162 4175 1:CAS:528:DC%2BD2cXnt1Citrc%3D 10.1210/en.2004-0201 15142985 (Pubitemid 39120565)
8. KW Broman H Wu S Sen GA Churchill 2003 R/qtl: QTL mapping in experimental crosses Bioinformatics 19 889 890 1:CAS:528:DC%2BD3sXjsVKmtb0%3D 10.1093/bioinformatics/btg112 12724300 (Pubitemid 36582406)
9. SC Collins RH Wallis SP Wilder KJ Wallace K Argoud PJ Kaisaki MT Bihoreau D Gauguier 2006 Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats Mamm Genome 17 538 547 10.1007/s00335-005-0168-y 16783636
10. RW Doerge GA Churchill 1996 Permutation tests for multiple loci affecting a quantitative character Genetics 142 285 294 1:STN:280:DyaK28zms1Chug%3D%3D 8770605
11. ME Dumas SP Wilder MT Bihoreau RH Barton JF Fearnside K Argoud L D'Amato RH Wallis C Blancher HC Keun D Baunsgaard J Scott UG Sidelmann JK Nicholson D Gauguier 2007 Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models Nat Genet 39 666 672 1:CAS:528:DC%2BD2sXksFersbw%3D 10.1038/ng2026 17435758 (Pubitemid 46676110)
12. H Edlund 2001 Developmental biology of the pancreas Diabetes 50 Suppl 1 S5 S9 1:CAS:528:DC%2BD3MXhtVOgsbo%3D 10.2337/diabetes.50.2007.S5 11272202
13. D Gauguier P Froguel V Parent C Bernard MT Bihoreau B Portha MR James L Penicaud M Lathrop A Ktorza 1996 Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat Nat Genet 12 38 43 1:CAS:528:DyaK28XhsV2iuw%3D%3D 10.1038/ng0196-38 8528248 (Pubitemid 26011317)
14. GK Gittes 2009 Developmental biology of the pancreas: a comprehensive review Develop Biol 326 4 35 1:CAS:528:DC%2BD1MXhtlKgs7o%3D 10.1016/j.ydbio. 2008.10.024 19013144
15. Goto Y, Suzuki KI, Sasaki M, Ono T, Abe S (1988) GK rat as a model of nonobese, noninsulin-dependent diabetes. Selective breeding over 35 generations. In: Shafrir E, Renold AE (eds) Lessons from animal diabetes II. Libbey, J, London, pp 301-303
16. JF Habener DM Kemp MK Thomas 2005 Minireview: transcriptional regulation in pancreatic development Endocrinology 146 1025 1034 1:CAS:528: DC%2BD2MXitlehsL0%3D 10.1210/en.2004-1576 15604203 (Pubitemid 40289291)
17. CS Haley SA Knott 1992 A simple regression method for mapping quantitative trait loci in line crosses using flanking markers Heredity 69 315 324 1:STN:280:DC%2BD283ovFaltQ%3D%3D 16718932
18. Y Hu PJ Kaisaki K Argoud SP Wilder KJ Wallace PY Woon C Blancher L Tarnow PH Groop S Hadjadj M Marre HH Parving M Farrall RD Cox M Lathrop N Vionnet MT Bihoreau D Gauguier 2009 Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus BMC Med Genomics 2 41 10.1186/1755-8794-2-41 19586551
19. R Ihaka R Gentleman 1996 R: a language for data analysis and graphics J Comput Graph Statist 5 299 314 10.2307/1390807
20. SE Kahn 2003 The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 3 19 1:CAS:528:DC%2BD3sXhtVKkt74%3D 10.1007/s00125-003-1190-9 12637977
21. SE Kahn S Zraika KM Utzschneider RL Hull 2009 The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality Diabetologia 52 1003 1012 1:CAS:528:DC%2BD1MXlt1GqtLo%3D 10.1007/s00125-009-1321-z 19326096
22. C Kargar A Ktorza 2008 Anatomical versus functional beta-cell mass in experimental diabetes Diabetes Obes Metab 10 Suppl 4 43 53 1:CAS:528: DC%2BD1cXhsVeqsb7O 10.1111/j.1463-1326.2008.00940.x 18834432
23. C Lambillotte P Gilon JC Henquin 1997 Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets J Clin Invest 99 414 423 1:CAS:528:DyaK2sXhtVKksbs%3D 10.1172/JCI119175 9022074
24. K Lindberg SG Ronn D Tornehave H Richter JA Hansen J Romer M Jackerott N Billestrup 2005 Regulation of pancreatic beta-cell mass and proliferation by SOCS-3 J Mol Endocrinol 35 231 243 1:CAS:528:DC%2BD2MXhtFyhsLbL 10.1677/jme.1.01840 16216905 (Pubitemid 41556172)
25. BA Menge H Schrader TG Breuer Y Dabrowski W Uhl WE Schmidt JJ Meier 2009 Metabolic consequences of a 50% partial pancreatectomy in humans Diabetologia 52 306 317 1:CAS:528:DC%2BD1MXjvFGjsw%3D%3D 10.1007/s00125-008-1219-1 19037627
26. H Mziaut S Kersting KP Knoch WH Fan M Trajkovski K Erdmann H Bergert F Ehehalt HD Saeger M Solimena 2008 ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs Proc Natl Acad Sci USA 105 674 679 1:CAS:528:DC%2BD1cXpvFSgsA%3D%3D 10.1073/pnas.0710931105 18178618 (Pubitemid 351171767)
27. B Portha 2005 Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm Diabetes Metab Res Rev 21 495 504 1:CAS:528:DC%2BD2MXhtlSrtbjN 10.1002/dmrr.566 15926190 (Pubitemid 41646009)
28. S Puri M Hebrok 2010 Cellular plasticity within the pancreas-lessons learned from development Develop Cell 18 342 356 1:CAS:528:DC%2BC3cXlsVShtrY%3D 10.1016/j.devcel.2010.02.005
29. J Rahier RM Goebbels JC Henquin 1983 Cellular composition of the human diabetic pancreas Diabetologia 24 366 371 1:STN:280:DyaL3s3mt1ylsw%3D%3D 10.1007/BF00251826 6347784
30. J Rahier Y Guiot RM Goebbels C Sempoux JC Henquin 2008 Pancreatic beta-cell mass in European subjects with type 2 diabetes Diabetes Obes Metab 10 Suppl 4 32 42 10.1111/j.1463-1326.2008.00969.x 18834431
31. F Ranta D Avram S Berchtold M Dufer G Drews F Lang S Ullrich 2006 Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4 Diabetes 55 1380 1390 1:CAS:528:DC%2BD28XksFahtLk%3D 10.2337/db05-1220 16644695 (Pubitemid 44195377)
32. LA Slezak DK Andersen 2001 Pancreatic resection: effects on glucose metabolism World J Surg 25 452 460 1:STN:280:DC%2BD3M3kt1ertA%3D%3D 10.1007/s002680020337 11344398 (Pubitemid 32455198)
33. BS Spooner BT Walther WJ Rutter 1970 The development of the dorsal and ventral mammalian pancreas in vivo and in vitro J Cell Biol 47 235 246 1:CAS:528:DyaE3MXhvVei 10.1083/jcb.47.1.235 5513553
34. P Stam 1993 Construction of integrated genetic linkage maps by means of a new computer package JoinMap. Plant J 3 739 744 1:CAS:528:DyaK3sXlvFKktLc%3D 10.1111/j.1365-313X.1993.00739.x
35. DJ Steiner A Kim K Miller M Hara 2010 Pancreatic islet plasticity: interspecies comparison of islet architecture and composition Islets 2 135 145 10.4161/isl.2.3.11815 20657742
36. HK Ury 1976 A comparison of four procedures for multiple comparisons among means (pairwise contrasts) for arbitrary samples sizes Technometrics 18 89 97 10.2307/1267921
37. KJ Wallace RH Wallis SC Collins K Argoud PJ Kaisaki A Ktorza PY Woon MT Bihoreau D Gauguier 2004 Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q Physiol Genomics 19 1 10 1:CAS:528:DC%2BD2cXoslSiur4%3D 10.1152/physiolgenomics.00114.2004 15266047
38. RH Wallis KJ Wallace SC Collins M McAteer K Argoud MT Bihoreau PJ Kaisaki D Gauguier 2004 Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8 Diabetologia 47 1096 1106 1:CAS:528:DC%2BD2cXltVKmtLo%3D 10.1007/s00125-004-1416-5 15164172
39. RH Wallis SC Collins PJ Kaisaki K Argoud SP Wilder KJ Wallace M Ria A Ktorza P Rorsman MT Bihoreau D Gauguier 2008 Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome PLoS One 3 e2962 10.1371/journal.pone.0002962 18698428
40. AJ Weinhaus NV Bhagroo TC Brelje RL Sorenson 2000 Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy Endocrinology 141 1384 1393 1:CAS:528: DC%2BD3cXisFOktb0%3D 10.1210/en.141.4.1384 10746642 (Pubitemid 32269106)
41. LA Weiss L Pan M Abney C Ober 2006 The sex-specific genetic architecture of quantitative traits in humans Nat Genet 38 218 222 1:CAS:528: DC%2BD28XotlGktA%3D%3D 10.1038/ng1726 16429159 (Pubitemid 43177237)
42. SP Wilder MT Bihoreau K Argoud TK Watanabe M Lathrop D Gauguier 2004 Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome Genome Res 14 758 765 1:CAS:528:DC%2BD2cXjt1yjtLw%3D 10.1101/gr.2001604 15060020 (Pubitemid 38500250)
43. F Zhang A Sjoholm Q Zhang 2009 Growth hormone signaling in pancreatic beta-cells-calcium handling regulated by growth hormone Mol Cell Endocrinol 297 50 57 1:CAS:528:DC%2BD1cXhsFajt7rM 10.1016/j.mce.2008.06.001 18602447