Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses

Equine Veterinary Journal

Volumn 42, Issue SUPPL. 38, 2010, Pages 601-605

  Foreman, J H ^a   Grubb, T L ^a,b   Inoue, O J ^a,c   Banner, S E ^a,d   Ball, K T ^a,e  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c The Equine Center   (United States)

^d Edisto Equine Clinic   (United States)

^e Mokena Animal Clinic   (United States)

Author keywords

Exercise; Heart rate; Horse; Nonsteroidal anti inflammatory drug; NSAID

Indexed keywords

CLONIXIN; DRUG DERIVATIVE; FLUNIXIN MEGLUMINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENYLBUTAZONE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL LAMENESS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ADMINISTRATION; FEMALE; HORSE; HORSE DISEASE; RANDOMIZED CONTROLLED TRIAL; SHOE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CLONIXIN; DRUG ADMINISTRATION SCHEDULE; FEMALE; HORSE DISEASES; HORSES; LAMENESS, ANIMAL; PHENYLBUTAZONE; PHYSICAL CONDITIONING, ANIMAL; SHOES;

EQUIDAE;

EID: 78249272976     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00232.x     Document Type: Article

References (19)

1. Dirikolu, L., Woods, W.E., Boyles J., Jr, Lehner, A.F., Harkins, J.D., Fisher, M., Schaeffer, D.J. and Tobin, T. (2009) Nonsteroidal anti-inflammatory agents and musculoskeletal injuries in Thoroughbred racehorses in Kentucky. J. vet. Pharmacol. Therap. 32, 271-279.
2. Doucet, M.Y., Bertone, A.L., Hendrickson, D., Hughes, F., MacAllister, C., McClure, S., Reinemeyer, C., Rossier, Y., Sifferman, R., Vrins, A.A., White, G., Kunkle, B., Alva, R., Romano, D. and Hanson, P.D. (2008) Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J. Am. vet. med. Ass. 232, 91-97.
3. Erkert, R.S., MacAllister, C.G., Payton, M.E. and Clarke, C.R. (2005) Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome. Am. J. vet. Res. 66, 284-288.
4. Foreman, J.H. and Rabin, D. (1984) Determination of accuracy of a digitally displaying equine heart rate meter. J. equine vet. Sci. 4, 161-163.
5. Foreman, J.H. and Lawrence, L.M. (1987) Lameness and heart rate elevation in the exercising horse. Proc. equine Nutr. Physiol. Symp. 10, 345-350.
6. Foreman, J.H., Grubb, T.L. and Inoue, O.J. (1994) Comparison of the effects of flunixin meglumine and ketoprofen on experimentally-induced lameness in the horse. Proc. Am. Ass. equine Practnrs. 40, 51.
7. Foreman, J.H., Bayly, W.M., Grant, B.D. and Gollnick, P.D. (1990) Standardized exercise test and daily heart rate responses of Thoroughbred horses to conventional race training. Am. J. vet. Res. 50, 914-920.
8. Foreman, J.H., Barange, A., Lawrence, L.M. and Hungerford, L.L. (2008) Effects of single-dose intravenous phenylbutazone on experimentally-induced, reversible lameness in the horse. J. vet. Pharmacol. Therap. 31, 39-44.
9. Goetz, T.E. and Comstock, C. (1985) The use of the adjustable heart bar shoe in the treatment of laminitis in horses. Proc. Am. Ass. equine Practnrs. 31, 605-616.
10. Hamm, D., Turchi, P., Johnson, J.C., Lockwood, P.W., Thompson, K.C. and Katz, T. (1997) Determination of an effective dose of eltenac and its comparison with that of flunixin meglumine in horses after experimentally induced carpitis. Am. J. vet. Res. 58, 298-302.
11. Hu, H.H., MacAllister, C.G., Payton, M.E. and Erkert, R.S. (2005) Evaluation of the analgesic effects of phenylbutazone administered at a high or low dosage in horses with chronic lameness. J. Am. vet. med. Ass. 226, 414-417.
12. Kallings, P., Johnston, C. and Drevemo, S. (1999) Effects of flunixin on movement and performance of standardbred trotters on the track. Equine vet. J. 30, 270-273.
13. Keegan, K.G., Messer, N.T., Reed, S.K., Wilson, D.A. and Kramer, J. (2008) Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses. Am. J. vet. Res. 69, 167-173.
14. Owens, J.G., Kammerling, S.G., Stanton, S.R. and Keowen, M.L. (1995) Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in horses. Equine vet. J. 27, 296-300.
15. Owens, J.G., Kammerling, S.G., Stanton, S.R., Keowen, M.L. and Prescott-Matthews, J.S. (1996) Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses. Am. J. vet. Res. 57, 866-874.
16. Schoonover, M.J., Jann, H.W. and Blaik, M.A. (2005) Quantitative comparison of three commonly used treatments for navicular syndrome in horses. Am. J. vet. Res. 66, 1247-1251.
17. Sebaté, D., Homedes, J., Salichs, M., Sust, M. and Monreal, L. (2009) Multicentre, controlled, randomized and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses. Equine vet. J. 41, 700-705.
18. Seino, K.K., Foreman, J.H., Greene, S.A., Goetz, T.E. and Benson, G.J. (2003) Effects of topical perineural capsaicin in a reversible model of equine foot lameness. J. vet. intern. Med. 17, 563-566.
19. Thomas, K.K. (2002) Physiological Effects of Perineural Mepivacaine Anesthesia and Topical Perineural Capsaicin in a Reversible Model of Equine Foot Lameness. M.S. Thesis, University of Illinois, Urbana.