Effect of eucalyptus-extract chewing gum on oral malodor: A double-masked, randomized trial

Journal of Periodontology

Volumn 81, Issue 11, 2010, Pages 1564-1571

  Tanaka, Muneo ^a   Toe, Masahiro ^a   Nagata, Hideki ^a   Ojima, Miki ^a   Kuboniwa, Masae ^a   Shimizu, Katsumasa ^b   Osawa, Kenji ^b   Shizukuishi, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b Lotte Central Laboratory Co Ltd   (Japan)

Author keywords

Chewing gum; Eucalyptus; Halitosis; Randomized controlled trial; Sulfur compounds

Indexed keywords

PLACEBO; PLANT EXTRACT; SULFUR DERIVATIVE; VOLATILE ORGANIC COMPOUND;

ADULT; ARTICLE; CHEWING GUM; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EUCALYPTUS; FEMALE; FOLLOW UP; GAS CHROMATOGRAPHY; HALITOSIS; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; TONGUE;

ADULT; CHEWING GUM; CHROMATOGRAPHY, GAS; DOUBLE-BLIND METHOD; EUCALYPTUS; FEMALE; FOLLOW-UP STUDIES; HALITOSIS; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PLANT EXTRACTS; SULFUR COMPOUNDS; TONGUE; VOLATILE ORGANIC COMPOUNDS; YOUNG ADULT;

EID: 78249270433     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.100249     Document Type: Article

References (32)

1. Delanghe G, Ghyselen J, Bollen C, van Steenberghe D, Vandekerckhove BN, Feenstra L. An inventory of patients' response to treatment at a multidisciplinary breath odor clinic. Quintessence Int 1999;30:307-310.
2. Kleinberg I, Westbay G. Salivary and metabolic factors involved in oral malodor formation. J Periodontol 1992;63:768-775.
3. Loesche WJ, De Boever EH. Strategies to identify the main microbial contributors to oral malodor. In: Rosenberg M, ed. Bad Breath: Research Perspectives. Tel Aviv, Israel: Ramot Publishing; 1995:41-54.
4. Bosy A, Kulkarni GV, Rosenberg M, McCulloch CAG. Relationship of oral malodor to periodontitis: Evidence of independence in discrete subpopulations. J Periodontol 1994;65:37-46.
5. Kozlovsky A, Goldberg S, Natour I, Rogatky-Gat A, Gelernter I, Rosenberg M. Efficacy of a 2-phase oil: Water mouthrinse in controlling oral malodor, gingivitis, and plaque. J Periodontol 1996;67:577-582.
6. Quirynen M, Mongardini C, van Steenberghe D. The effect of a 1-stage full-mouth disinfection on oral malodor and microbial colonization of the tongue in periodontitis. A pilot study. J Periodontol 1998;69:374-382.
7. Young A, Jonski G, Rölla GA. A study of triclosan and its solubilizers as inhibitors of oral malodour. J Clin Periodontol 2002;29:1078-1081.
8. Young A, Jonski G, Rölla G. Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride - effect of concentration. Eur J Oral Sci 2003;111:400-404.
9. Roldán S, Winkel EG, Herrera D, Sanz M, Van Winkelhoff AJ. The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: A dualcentre, double-blind placebo-controlled study. J Clin Periodontol 2003;30:427-434. (Pubitemid 38037101)
10. Nagata H, Inagaki Y, Yamamoto Y, et al. Inhibitory effects of macrocarpals on the biological activity of Porphyromonas gingivalis and other periodontopathic bacteria. Oral Microbiol Immunol 2006;21:159-163.
11. Tanaka M, Yamamoto Y, Kuboniwa M, et al. Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor. Microbes Infect 2004;6:1078-1083.
12. Nagata H, Inagaki Y, Tanaka M, et al. Effect of eucalyptus extract chewing gum on periodontal health: A double-masked, randomized trial. J Periodontol 2008;79:1378-1385.
13. Miyazaki H, Sakao S, Katoh Y, Takehara T. Correlation between volatile sulphur compounds and certain oral health measurements in the general population. J Periodontol 1995;66:679-684.
14. Saito H, Kawaguchi Y. Halitosis prevention campaign: A report of oral health promotion activities in Japan. Int Dent J 2002;52(Suppl. 3):197-200.
15. Bornstein MM, Stocker BL, Seemann R, Bürgin WB, Lussi A. Prevalence of halitosis in young male adults: A study in Swiss army recruits comparing selfreported and clinical data. J Periodontol 2009;80:24-31.
16. Coil J, Tonzetich J. Characterization of volatile sulfur compounds production at individual gingival crevicular sites in humans. J Clin Dent 1992;3:97-103.
17. Delanghe G, Ghyselen J, van Steenberghe D, Feenstra L. Multidisciplinary breath-odor clinic. Lancet 1997;350:187.
18. Rosenberg M. Bad breath and periodontal disease: How related are they? J Clin Periodontol 2006;33:29-30.
19. Greenberg M, Urnezis P, Tian M. Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor. J Agric Food Chem 2007;55:9465-9469.
20. Lodhia P, Yaegaki K, Khakbaznejad A, et al. Effect of green tea on volatile sulfur compounds in mouth air. J Nutr Sci Vitaminol (Tokyo) 2008;54:89-94.
21. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551.
22. Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics 1975;31:103-115.
23. Oho T, Yoshida Y, Shimazaki Y, Yamashita Y, Koga T. Characteristics of patients complaining of halitosis and the usefulness of gas chromatography for diagnosing halitosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:531-534.
24. Shimura M, Watanabe S, Iwakura M, et al. Correlation between measurements using a new halitosis monitor and organoleptic assessment. J Periodontol 1997;68:1182-1185.
25. Kieser M, Wassmer G. On the use of the upper confidence limit for the variance from a pilot sample for sample size determination. Biometrical J 1996;38:941-949. (Pubitemid 126345583)
26. Rosenberg M, Kulkarni GV, Bosy A, McCulloch CA. Reproducibility and sensitivity of oral malodor measurements with a portable sulphide monitor. J Dent Res 1991;70:1436-1440.
27. Rosenberg M, Gelernter I, Barki M, Bar-Ness R. Daylong reduction of oral malodor by a two-phase oil: Water mouthrinse as compared to chlorhexidine and placebo rinses. J Periodontol 1992;63:39-43.
28. van Steenberghe D, Avontroodt P, Peeters W, et al. Effect of different mouthrinses on morning breath. J Periodontol 2001;72:1183-1191.
29. Brading MG, Cromwell VJ, Green AK, DeBrabander S, Beasley T, Marsh PD. The role of Triclosan in dentifrice formulations, with particular reference to a new 0.3% Triclosan calcium carbonate-based system. Int Dent J 2004;54(Suppl. 5):291-298.
30. Paraskevas S, Rosema NA, Versteeg P, Van der Velden U, Van der Weijden GA. Chlorine dioxide and chlorhexidine mouthrinses compared in a 3-day plaque accumulation model. J Periodontol 2008;79:1395-1400.
31. Saito MV, Nagata H, Maeda K, et al. Antibacterial activity of extracts from eucalyptus leaves on periodontopathic bacteria. J Dent Health (Tokyo) 2003;53:585-591.
32. Shinada K, Ueno M, Konishi C, et al. Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: A randomized placebo-controlled 7-day trial. Trials 2010;11:14.