Pharmacokinetics and metabolism of the dipeptidyl peptidase IV inhibitor carmegliptin in rats, dogs, and monkeys

Xenobiotica

Volumn 40, Issue 12, 2010, Pages 840-852

  Kuhlmann, Olaf ^a   Paehler, Axel ^a   Weick, Idelette ^a   Funk, Christoph ^a   Pantze, Michael ^a   Zell, Manfred ^a   Timm, Uwe ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

distribution; Excretion

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CARMEGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EXCRETION; DRUG TISSUE LEVEL; DRUG TRANSPORT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTESTINE SECRETION; LIVER METABOLISM; MALE; NONHUMAN; NORMAL HUMAN; RADIATION DOSE; RAT; TISSUE DISTRIBUTION; WISTAR RAT;

ABSORPTION; ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; BLOOD PROTEINS; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; HAPLORHINI; INJECTIONS, INTRAVENOUS; MEMBRANE TRANSPORT PROTEINS; QUINOLIZINES; RATS; TISSUE DISTRIBUTION;

CANIS FAMILIARIS; MACACA FASCICULARIS; RATTUS; RATTUS NORVEGICUS;

EID: 78249267588     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.519406     Document Type: Article

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