Critical hematocrit and oxygen partial pressure in the beating heart of pigs

Microvascular Research

Volumn 80, Issue 3, 2010, Pages 389-393

  Hiebl, B ^a   Mrowietz, C ^a   Ploetze, K ^b   Matschke, K ^b   Jung, F ^a,b  

^a INSTITUTE OF MATERIALS RESEARCH   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Hematocrit; Hemodilution; Ischemia; Pigs

Indexed keywords

GELATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VOLUME; CONTROLLED STUDY; FEMALE; HEART BEAT; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEMATOCRIT; HEMODILUTION; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; SKELETAL MUSCLE; SWINE;

ANIMALS; BLOOD PRESSURE; FEMALE; GELATIN; HEART RATE; HEMATOCRIT; HEMODILUTION; INFUSIONS, INTRAVENOUS; MUSCLE, SKELETAL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PLASMA SUBSTITUTES; SUCCINATES; SWINE; TIME FACTORS;

ANIMALIA; SUIDAE;

EID: 78249260877     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.06.002     Document Type: Article

References (37)

1. Crowell J.W., Smith E.E. Determinant of the optimal hematocrit. J. Appl. Physiol. 1967, 22:501-504.
2. Gaehtgens P., Kreutz F., Albrecht K.H. Optimal hematocrit for canine skeletal-muscle during rhythmic isotonic exercise. Eur. J. Appl. Physiol. 1979, 41:27-39.
3. Hoffkes H.G., Ehrly A.M. Optimal hematocrit in patients with intermittent claudication-exercise induced muscle-tissue oxygen-pressure after stepwise isovolemic hemodilution. Clin. Hemorheol. 1992, 12:41-56.
4. Hoffkes H.G., Dehn R., SaegerLorenz K., Franke A., Landgraf H., Ehrly A.M. Effects of normovolemic and hypervolemic hematocrit variations on muscle tissue oxygen pressure in patients with chronic ischemia of the calf muscle. Clin. Hemorheol. 1996, 16:249-265.
5. Hogan M.C., Bebout D.E., Wagner P.D. Effect of hemoglobin concentration on maximal O2 uptake in canine gastrocnemius muscle in situ. J. Appl. Physiol. 1991, 70:1105-1112.
6. Crystal G.J., Kim S.J., Salem M.R. Right and left-ventricular O2 uptake during hemodilution and beta-adrenergic stimulation. Am. J. Physiol. 1993, 265:H1769-H1777.
7. Levy P.S., Kim S.J., Eckel P.K., Chavez R., Ismail E.F., Gould S.A., Salem M.R., Crystal G.J. Limit to cardiac compensation during acute isovolemic hemodilution - influence of coronary stenosis. Am. J. Physiol. 1993, 265:H340-H349.
8. Cain S.M. Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J. Appl. Physiol. 1977, 42:228-234.
9. Meier J., Kemming G.I., Kisch-Wedel H.K., Wolkhammer S., Habler O.P. Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 2004, 100:70-76.
10. van Bommel J., Siegemund M., Henny C.P., Trouwborst A., Ince C. Critical hematocrit in intestinal tissue oxygenation during severe normovolemic hemodilution. Anesthesiology 2001, 94:152-160.
11. Welte M. Is there such a thing as critical hematocrit?. Anaesthesist 2001, 50:S2-S8.
12. Hughes G.C., Post M.J., Simons M., Annex B.H. Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis. J. Appl. Physiol. 2003, 94:1689-1701.
13. Halstead J.C., Wurm M., Meier D.M., Zhang N., Spielvogel D., Weisz D., Bodian C., Griepp R.B. Avoidance of hemodilution during selective cerebral perfusion enhances neurobehavioral outcome in a survival porcine model. Eur. J. Cardiothorac. Surg. 2007, 32:514-520.
14. Jung F., Erdlenbruch W., Koscielny J., Kiesewetter H. Influence of ISO- and hypervolaemic haemodilution with hydroxyethyl starch 200/0.5 10% on blood fluidity and intramuscular oxygen pressure in patients with peripheral occlusive arterial disease. Clin. Hemorheol. 1996, 16:329-342.
15. Boekstegers P., Peter W., Vondegenfeld G., Nienaber C.A., Abend M., Rehders T.C., Habazettl H., Kapsner T., Vonludinghausen M., Werdan K. Preservation of regional myocardial-function and myocardial oxygen-tension during acute-ischemia in pigs - comparison of selective synchronized suction and retroinfusion of coronary veins to synchronized coronary venous retroperfusion. J. Am. Coll. Cardiol. 1994, 23:459-469.
16. Jung F., Toonen H., Mrowietz C., Wolf S., Kiesewetter H., Wenzel E., Gersonde K., Muller G. Error analysis, biological influencing factors, and variance of periungual video capillary microscopy. Biomed. Tech. (Berl) 1990, 35:195-204.
17. Matschke K., Mrowietz C., Park J.W., Jung R. Monitoring of myocardial oxygen tension in a beating heart: results of an animal model. Clin. Hemorheol. Microcirc. 2004, 30:273-276.
18. Braunwald E., Frahm C.J. Studies on Starling's law of the heart: IV. Observations on the hemodynamic functions of the left atrium in man. Circulation 1961, 24:633-642.
19. Jung F., Koscielny J., Kolepke W., Kiesewetter H., Wenzel E. Influence of isovolemic and hypervolemic hemodilution on the flow properties of blood, oxygen transport capacity in the macrocirculation and microcirculation, and tissue oxygen pressure in skin and skeletal muscle. Hydroxyethyl Starch 1992, 85-106. Georg Thieme, Stuttgart. P. Lawin, J. Zander, B. Weidler (Eds.).
20. Chilian W.M., Bassingthwaighte J.B., Cannon R.O., Curry F.R.E., Davis M.J., Dellsperger K.C., Duling B.R., Fuster V., Gerritsen M.E., Hoffman J.I.E., Kajiya F., Ku D.D., Lamping K.G., Laughlin M.H., Ritman E.L., Taylor A.E., Small A. Coronary microcirculation in health and disease - summary of an NHLBI workshop. Circulation 1997, 95:522-528.
21. Lindbom L., Mirhashemi S., Arfors K.E., Intaglietta M. Blood-flow and hematocrit distribution in response to acute normovolemic hemodilution. Int. J. Microcirc. Clin. Exp. 1986, 5:278.
22. Tsai A.G., Arfors K.E., Intaglietta M. Spatial-distribution of red-blood-cells in individual skeletal-muscle capillaries during extreme hemodilution. Int. J. Microcirc. Clin. Exp. 1991, 10:317-334.
23. Jung F., Kosclelny J., Mrowietz C., Wolf S., Kiesewetter H., Wenzel E. Einfluss der Hämodilution auf den systemischen und den Kapillarhämatokrit. Infusionstherapie 1990, 17:268-275.
24. Lindbom L., Mirhashemi S., Intaglietta M., Arfors K.E. Increase in capillary blood-flow and relative hematocrit in rabbit skeletal-muscle following acute normovolemic anemia. Acta Physiol. Scand. 1988, 134:503-512.
25. Cabrales P., Tsai A.G. Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H2445-H2452.
26. Tsai A.G., Acero C., Nance P.R., Cabrales P., Frangos J.A., Buerk D.G., Intaglietta M. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am. J. Physiol. Heart Circ. Physiol. 2005, 288:H1730-H1739.
27. Habler O.P., Messmer K.F.W. The physiology of oxygen transport. Transfus. Sci. 1997, 18:425-435.
28. Matschke K., Jung F. Regulation of the myocardial microcirculation. Clin. Hemorheol. Microcirc. 2008, 39:265-279.
29. Hutter J.W., Podtschaske A.H., Tiede M., Kemming G.I., Corso C.O., Batra S., Keipert P., Faithfull N., Messmer K. Effects of hemodilution on splanchnic perfusion and hepatorenal functions. Eur. J. Med. Res. 1997, 2:419-424.
30. Spahn D.R., Leone B.J., Reves J.G., Pasch T. Cardiovascular and coronary physiology of acute isovolemic hemodilution - a review of nonoxygen-carrying and oxygen-carrying solutions. Anesth. Analg. 1994, 78:1000-1021.
31. Chien S. The present state of blood rheology. Hemodilution. Theoretical Basis and Clinical Application 1972, 1-45. Karger, Basel. K. Messmer, H. Schmid-Schönbein (Eds.).
32. Merrill E.W. Rheology of blood. Physiol. Rev. 1969, 49:863.
33. Stuart J., Kenny M.W. Blood rheology. J. Clin. Pathol. 1980, 33:417-429.
34. Habler O.P., Kleen M.S., Podtschaske A.H., Hutter J.W., Tiede M., Kemming G.I., Welte M.V., Corso C.O., Messmer K.F. The effect of acute normovolemic hemodilution (ANH) on myocardial contractility in anesthetized dogs. Anesth. Analg. 1996, 83:451-458.
35. Doss D.N., Estafanous F.G., Ferrario C.M., Brum J.M., Murray P.A. Mechanism of systemic vasodilation during normovolemic hemodilution. Anesth. Analg. 1995, 81:30-34.
36. Matschke K., Pfeiffer S., Mrowietz C., Geisler T., Tugtekin S.M., Park J.W., Knaut M., Jung F. Influence of ventricular pacing on myocardial oxygen tension. Microvasc. Res. 2005, 70:97-101.
37. Taneja R., Fernandes P., Marwaha G., Cheng D., Bainbridge D. Perioperative coagulation management and blood conservation in cardiac surgery: a Canadian survey. J. Cardiothorac. Vasc. Anesth. 2008, 22:662-669.