Emergence of carbapenem resistance due to porin loss in an extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain during meropenem therapy

International Journal of Antimicrobial Agents

Volumn 36, Issue 6, 2010, Pages 575-576

  Webster, D P ^a   Gaulton, T ^b   Woodford, N ^b   Pike, R ^b   Turton, J ^b   Perry, C ^b   Bowler, I C J W ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN; CARBAPENEM; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; ERTAPENEM; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; LINEZOLID; MEROPENEM; OUTER MEMBRANE PROTEIN; PIPERACILLIN PLUS TAZOBACTAM; PORIN; VANCOMYCIN;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL STRAIN; BACTERIUM ISOLATION; BLOOD CULTURE; CANCER CHEMOTHERAPY; CASE REPORT; DEATH; DISEASE COURSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEBRILE NEUTROPENIA; HEMATOLOGIC MALIGNANCY; HUMAN; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LARGE CELL LYMPHOMA; LETTER; MALE; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PULSED FIELD GEL ELECTROPHORESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; PORINS; THIENAMYCINS;

EID: 78249260635     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.08.003     Document Type: Letter

References (5)

1. Patel G., Huprikar S., Factor S.H., Jenkins S.G., Calfee D.P. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect Control Hosp Epidemiol 2008, 29:1099-1106.
2. Miriagou V., Cornaglia G., Edelstein M., Galani I., Giske C.G., Gniadkowski M., et al. Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues. Clin Microbiol Infect 2010, 16:112-122.
3. Yang D., Guo Y., Zhang Z. Combined porin loss and extended spectrum β-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical Klebsiella pneumoniae strains. Curr Microbiol 2009, 58:366-370.
4. Skurnik D., Lasocki S., Bremont S., Muller-Serieys C., Kitzis M.D., Courvalin P., et al. Development of ertapenem resistance in a patient with mediastinitis caused by Klebsiella pneumoniae producing an extended-spectrum β-lactamase. J Med Microbiol 2010, 59:115-119.
5. Doumith M., Ellington M.J., Livermore D.M., Woodford N. Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother 2009, 63:659-667.