Mechanism of anti-diabetic action, efficacy and safety profile of gii purified from fenugreek (trigonella foenum-graceum linn.) seeds in diabetic animals

Indian Journal of Experimental Biology

Volumn 48, Issue 11, 2010, Pages 1119-1122

  Moorthy, Radha ^a   Prabhu, K M ^a   Murthy, P S ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Diabetes mellitus; Fenugreek; Gii; Trigonella foenum graceum

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ALLOXAN; ANTIDIABETIC AGENT; FRUCTOSE BISPHOSPHATASE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; LIPID; PLANT EXTRACT; PYRUVATE KINASE;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; FENUGREEK; GLYCOLYSIS; HEART; HEART MUSCLE; HUMAN; ISOLATION AND PURIFICATION; KIDNEY; LIVER; MALE; METABOLISM; MUSCLE; PATHOLOGY; PHYTOTHERAPY; PLANT SEED; RABBIT;

ALLOXAN; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FRUCTOSE-BISPHOSPHATASE; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; GLYCOLYSIS; HEART; HUMANS; HYPOGLYCEMIC AGENTS; KIDNEY; LIPIDS; LIVER; MALE; MUSCLES; MYOCARDIUM; PHOSPHOFRUCTOKINASES; PHYTOTHERAPY; PLANT EXTRACTS; PYRUVATE KINASE; RABBITS; SEEDS; TRIGONELLA;

ANIMALIA; ORYCTOLAGUS CUNICULUS; TRIGONELLA FOENUM; TRIGONELLA FOENUM-GRAECUM;

EID: 78249255170     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Moorthy Radha, Prabhu K M & Murthy P S, Purification of antihyperglycemic compound GII from fenugreek (Trigonella foenum-graecum) seeds useful in diabetes mellitus, Indian J Exp Biol, 48 (2010) 1111.
2. Lowry O H, Rosenbrough N J, Farr A L & Randall R J, Protein measurement with the Folin phenol reagent, J Biol Chem, 193 (1951) 265.
3. Carrol N V, Longley R W & Roe J H, The determination of glycogen in liver and muscle by the anthrone reagent, J Biol Chem, 220 (1956) 583.
4. Folch J, Lees M & Stanley G H S, A simple method for the isolation and purification of total lipids from animal tissues, J Biol Chem, 226 (1957) 497.
5. Parker K M & England J D, Improved colorimetric assay for glycosylated hemoglobin, Clin. Chem, 27 (1981) 669.
6. Brod J & Sirota J H, The renal clearance of endogenous "Creatinine in man", J Clin Invest, 27 (1948) 645.
7. Marsh W H, Fingerhut B & Miller H, Automated and manual direct methods for the determination of blood urea, Clin Chem, 11 (1965) 624.
8. Kind P R N & King E J, Estimation of plasma phosphatase by determination of hydrolysed phenol with aminoantipyrine, J Clin Pathol, 7 (1954), 322.
9. Reitman S & Frankel S, A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Am J Clin Pathol, 28 (1957) 56.
10. Racker E J, Spectrophotometric measurement of hexokinase and phosphohexokinase activity, J Biol Chem, 167 (1947) 843.
11. Fiske C H & SubbaRow M, The colorimetric determination of phosphates, J Biol Chem, 66 (1925) 375.
12. Nordlie R C & Arion W J, Evidence for the common identity of glucose 6-phosphatase, inorganic pyrophosphatase, and pyrophosphate-glucose phosphotransferase, J Biol Chem, 239 (1964) 1680.
13. Tanaka T, Harano Y, Sue F & Morimura H, Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues, J Biochem, 62 (1967) 71.
14. Pilkis S J, Glucokinase of rat liver, Methods Enzymol, 42 (1975) 31.