Nucleus accumbens carbachol disrupts olfactory and contextual fear-potentiated startle and attenuates baseline startle reactivity

Behavioural Brain Research

Volumn 216, Issue 2, 2011, Pages 673-680

  Cousens, Graham A ^a   Skrobacz, Cheryl G ^a   Blumenthal, Anna ^a  

^a DREW UNIVERSITY   (United States)

Author keywords

Acoustic startle; Carbachol; Conditioned fear; Nucleus accumbens; Olfaction

Indexed keywords

CARBACHOL; CHOLINERGIC RECEPTOR;

ANALYSIS OF VARIANCE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTERIOR COMMISSURE; ARTICLE; BRAIN FUNCTION; CANNULA; CONDITIONING; CONTROLLED STUDY; FEAR; MALE; MOTOR ACTIVITY; NEUROMODULATION; NONHUMAN; NUCLEUS ACCUMBENS; ODOR; OLFACTORY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STARTLE REFLEX; STATE DEPENDENT LEARNING;

ANIMALS; AVOIDANCE LEARNING; CARBACHOL; CHOLINERGIC AGONISTS; CHOLINERGIC FIBERS; CONDITIONING, CLASSICAL; FEAR; MALE; MICROINJECTIONS; MOTOR ACTIVITY; NEURAL PATHWAYS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RETENTION (PSYCHOLOGY); SMELL; STARTLE REACTION;

EID: 78249232016     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.09.011     Document Type: Article

References (53)

1. Anthony B.J., Graham F.K. Blink reflex modification by selective attention: evidence for the modulation of 'automatic' processing. Biological Psychology 1985, 21:43-59.
2. Austin M.C., Kalivas P.W. The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior. Brain Research 1988, 441:209-214.
3. Calabresi P., Centonze D., Gubellini P., Pisani A., Bernardi G. Acetylcholine-mediated modulation of striatal function. Trends in Neuroscience 2000, 23:120-126.
4. Campeau S., Falls W.A., Cullinan W.E., Helmreich D.L., Davis M., Watson S.J. Elicitation and reduction of fear: behavioral and neuroendocrine indices and brain induction of the immediate-early gene c-fos. Neuroscience 1997, 78:1087-1104.
5. 2 muscarinic receptors disrupts operant responding for sucrose under a progressive ratio reinforcement schedule. Behavioural Brain Research 2007, 181(1):127-135.
6. Cousens G.A., Otto T. Both pre- and post-training excitotoxic lesions of the basolateral amygdala abolish the expression of olfactory and contextual fear conditioning. Behavioral Neuroscience 1998, 112:1092-1103.
7. Davis M. The role of the amygdala in conditioned and unconditioned fear and anxiety. The amygdala 2000, 213-288. Oxford Univeristy Press, Oxford, UK. J.P. Aggleton (Ed.).
8. Davis M., Schlesinger L.S., Sorenson C.A. Temporal specificity of fear conditioning: effects of different conditioned stimulus-unconditioned stimulus intervals on the fear-potentiatedstartle effect. Journal of Experimental Psychology: Animal Behavior Processes 1989, 15(4):295-310.
9. Fendt M., Fanselow M.S. The neuroanatomical and neurochemical basis of conditioned fear. Neuroscience and Biobehavioral Reviews 1999, 23:743-760.
10. Fendt M., Schwienbacher I., Schnitzler H.U. Carbachol injections into the nucleus accumbens induce 50kHz calls in rats. Neuroscience Letters 2006, 401(1-2):P10-P15.
11. Groenewegen H.J., Vermeulen-Van der Zee E., te Kortschot A., Witter M.P. Organization of the projections from the subiculum to the ventral striatum in the rat: a study using Phaseolus vulgaris-leucoagglutinin. Neuroscience 1987, 23:103-120.
12. Groenewegen H.J., Wright C.I., Beijer A.V., Voorn P. Convergence and segregation of ventral striatal inputs and outputs. Annals NY Academy of Sciences 1999, 877:49-63.
13. Haralambous T., Westbrook R.F. An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning. Behavioral Neuroscience 1999, 113(5):925-940.
14. Heimer L., Zahm D.S., Churchill L., Kalivas D.W., Wohltmann C. Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 1991, 41:89-125.
15. Ikemoto S., Glazier B.S., Murphy J.M., McBride WJ Rats self-administer carbachol directly into the nucleus accumbens. Physiology & Behavior 1998, 63(5):811-814.
16. Jongen-Relo A.L., Kaufmann S., Feldon J. A differntial involvement of the shell and core subterritories of the nucleus accumbens of rats in memory processes. Behavioral Neuroscience 2003, 117:150-168.
17. Josselyn S.A., Falls W.A., Gewirtz J.C., Pistell P., Davis M. The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior. Neuropsychopharmacology 2005, 30:17-26.
18. Knutson B., Burgdorf J., Panksepp J. Ultrasonic vocalizations as indices of affective states in rats. Psychological Bulletin 2002, 128:961-977.
19. Koch M., Kungel M., Herbert H. Cholinergic neurons in the pedunculopontine tegmental nucleus are inovlved in the mediationof prepulse inhibition of the acousticstartle response in the rat. Experimental Brain Research 1993, 97:71-82.
20. Koch M., Schmid A., Schnitzler H.U. Pleasure-attenuation of startle is disrupted by lesions of the nucleus accumbens. Neuroreport 1996, 7(8):1442-1446.
21. Koos T., Tepper J.M. Dual cholinergic control of fast-spiking interneurons in the neostriatum. Journal of Neuroscience 2002, 22:529-535.
22. Kodsi M., Swerdlow N.R. Regulation of prepulse inhibition by ventralpallidal projections. Brain Research Bulletin 1997, 43:219-228.
23. 1 receptor antagonist SCH 23390 into the amygdala blocks fear expression in a potentiated startle paradigm. Brain Research 1998, 795:128-136.
24. Lang P.J., Bradley M.M., Cuthbert B.N. Emotion, attention, and the startle reflex. Psychological Review 1990, 97:377-395.
25. LeDoux J.E. Emotion circuits in the brain. Annual Reviews of Neuroscience 2000, 23:155-184.
26. Levita L., Dalley J.W., Robbins T.W. Nucleus accumbens dopamine and learned fear revisited: a review and some new findings. Behavioural Brain Research 2002, 137:115-127.
27. Mark G.P., Weinberg J.B., Rada P.V., Hoebel B.G. Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus. Brain Research 1995, 688:184-188.
28. Mogenson G.J., Swanson L.W., Wu M. Neural projections from nucleus accumbens to globus pallidus substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat. Journal of Neuroscience 1983, 3:189-202.
29. Murphy C.A., Pezze M., Feldon J., Heidbreder C. Differential involvement of dopamine in the shell and cores of the nucleus accumbens in the expression of latent inhibition to an aversively conditioned stimulus. Neuroscience 2000, 97:469-477.
30. Nader K., Majidashad P., Amorapanth P., LeDoux J.E. Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learning and Memory 2001, 8(3):156-163.
31. Otto T., Cousens G.A., Rajewski K. Odor-guided fear conditioning in rats: I Acquisition, retention, and latent inhibition. Behavioral Neuroscience 1997, 111:1257-1264.
32. Paré D., Quirk G.J., Ledoux J.E. New vistas on amygdala networks in conditioned fear. Journal of Neurophysiology 2004, 92:1-9.
33. Parkinson J.A., Robbins T.W., Everitt B.J. Selective excitotoxic lesions of the nucleus accumbens core and shell differentially affect aversive Pavlovian conditioning to discrete and contextual cues. Psychobiology 1999, 27:256-266.
34. Paschall G.Y., Davis M. Olfactory-mediated fear-potentiated startle. Behavioral Neuroscience 2002, 116(1):4-12.
35. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2005, Elsevier Academic Press, Amsterdam. 5th ed.
36. Pezze M.A., Heidbreder C.A., Feldon J., Murphy C.A. Selective responding of nucleus accumbens core and shell dopamine ot aversively conditioned contextual and discrete stimuli. Neuroscience 2001, 108:91-102.
37. Pro-Sistiaga P., Mohedano-Moriano A., Ubeda-Banon I., Del Mar Arroyo-Jimenez M., Marcos-P, Artacho-Perula E., Crespo C., Insausti R., Martinez-Marcos A. Convergence of olfactory and vomeronasal projections in the rat basal telencephalon. Journal of Comparative Neurology 2007, 504:346-362.
38. Richardson R., Vishney A., Lee Conditioned odor potentiation of startle in rats. Behavioral Neuroscience 1999, 113(4):787-794.
39. Riedel G., Harrington N.R., Gall G., Macphail E.M. Nucleus accumbens lesions impair context, but not cue, conditioning in rats. NeuroReport 1997, 8:2477-2481.
40. de Rover M., Lodder J.C., Kits K.S., Schoffelmeer A.N., Brussaard A.B. Cholinergic modulation of nucleus accumbens medium spiny neurons. European Journal of Neuroscience 2002, 16:2279-2290.
41. Schmid A., Koch M., Schnitzler H.U. Conditioned pleasure attenuates the startle response in rats. Neurobiology of Learning and Memory 1995, 64(1):1-3.
42. Schneider M., Spanagel R. Appetitive odor-cue conditioning attenuates the acoustic startle response in rats. Behavioural Brain Research 2008, 189(1):226-230.
43. Schwienbacher I., Fend M., Richardson R., Schnitzler H.U. Temporary inactivation of the nucleus accumbens disrupts acquisition and expression of fear-potentiated startle in rats. Brain Research 2004, 1027:87-93.
44. Schwienbacher I., Fendt M., Schnitzler H.U. Amphetamine injections into the nucleus accumbens affect neither acquisition/expression of conditioned fear nor baseline startle response. Experimental Brain Research 2005, 160:538-544.
45. Schwienbacher I., Schnitzler H.U., Westbrook R.F., Richardson R., Fendt M. Carbachol injections into the nucleus accumbens disrupt acquisition and expression of fear-potentiated startle and freezing in rats. Neuroscience 2006, 140:769-778.
46. Swerdlow N.R., Geyer M.A. Prepulse inhibition of acoustic startle in rats after lesionsof the pedunculopontine nucleus. Behavioral Neuroscience 1993, 107:104-117.
47. Walker D.L., Paschall G.Y., Davis M. Glutamate receptor antagonist infusions into the basolateral and medial amygdala reveal differntial contributions ot olfactory vs. context fear conditioning and expression. Learning and Memory 1995, 12:120-129.
48. Westbrook R.F., Good A.J., Kiernan M. Microinjectionof morphine into the nucleus accumbens impairs contextual learning in rats. Behavioral Neuruoscience 1997, 111:996-1013.
49. Windels F., Kiyatkin E.A. Modulatory action of acetylcholine on striatal neurons: Microiontophoretic study in awake, unrestrained rats. European Journal of Neuroscience 2003, 17:613-622.
50. Wright C.I., Beijer A.V., Groenewegen H.J. Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized. Journal of Neuroscience 1996, 16:1877-1893.
51. Young A.M., Joseph M.H., Gray J.A. Latent inhibition of conditioned dopamine release in the rat nucleus accumbens. Neuroscience 1993, 54:5-9.
52. Young A.M., Ahier R.G., Upton R.L., Joseph M.H., Gray J.A. Increased extracellular dopamine in the nucleus accumbens of the rat during associative learning of neutral stimuli. Neuroscience 1998, 83:1175-1183.
53. Zhou F.M., Liang Y., Dani J.A. Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nature Neuroscience 2001, 4:1224-1229.