Funduscopy in adult zebrafish and its application to isolate mutant strains with ocular defects

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Tschopp, Markus ^a,d   Takamiya, Masanari ^b   Cerveny, Kara L ^c   Gestri, Gaia ^c   Biehlmaier, Oliver ^a   Wilson, Stephen W ^c   Strähle, Uwe ^b   Neuhauss, Stephan C F ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE SEGMENT; ARTICLE; CATARACT; CONTROLLED STUDY; CORNEA DISEASE; DIAGNOSTIC IMAGING; DNA MODIFICATION; EYE FUNDUS; EYE MALFORMATION; FEMALE; GENE MUTATION; GENETIC SCREENING; MOUSE; MUTANT; NONHUMAN; OCULAR BLOOD VESSEL; OPHTHALMOSCOPY; STEREOMICROSCOPY; TRANSGENIC ANIMAL; ZEBRA FISH; ANIMAL; EYE DISEASE; FISH DISEASE; GENETICS; METHODOLOGY; MUTATION; OPHTHALMOSCOPE; REPRODUCIBILITY; RETINA DISEASE; SENSITIVITY AND SPECIFICITY;

ANIMALIA; DANIO RERIO; RODENTIA;

ANIMALS; CATARACT; CORNEAL DISEASES; EYE DISEASES; FISH DISEASES; MICE; MUTATION; OPHTHALMOSCOPES; OPHTHALMOSCOPY; REPRODUCIBILITY OF RESULTS; RETINAL DISEASES; SENSITIVITY AND SPECIFICITY; ZEBRAFISH;

EID: 78149485176     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015427     Document Type: Article

References (28)

1. Helmholtz H (1851) Beschreibung eines Augenspiegels zur Untersuchung der Netzhaut im lebenden Auge. Berlin: A. Förstner'sche Verlagsbuchhandlung.
2. Ravin JG (1999) Sesquicentennial of the ophthalmoscope. Arch Ophthalmol 117: 1634-1638.
3. Fadool JM, Dowling JE (2008) Zebrafish: a model system for the study of eye genetics. Prog Retin Eye Res 27: 89-110.
4. Neuhauss SC (2003) Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol 54: 148-160.
5. Neuhauss SC, Biehlmaier O, Seeliger MW, Das T, Kohler K, et al. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci 19: 8603-8615.
6. Dahm R, Schonthaler HB, Soehn AS, van Marle J, Vrensen GF (2007) Development and adult morphology of the eye lens in the zebrafish. Exp Eye Res 85: 74-89.
7. Paques M, Guyomard JL, Simonutti M, Roux MJ, Picaud S, et al. (2007) Panretinal, high-resolution color photography of the mouse fundus. Invest Ophthalmol Vis Sci 48: 2769-2774.
8. Hawes NL, Smith RS, Chang B, Davisson M, Heckenlively JR, et al. (1999) Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5: 22.
9. Cohan BE, Pearch AC, Jokelainen PT, Bohr DF (2003) Optic disc imaging in conscious rats and mice. Invest Ophthalmol Vis Sci 44: 160-163.
10. Paques M, Tadayoni R, Sercombe R, Laurent P, Genevois O, et al. (2003) Structural and hemodynamic analysis of the mouse retinal microcirculation. Invest Ophthalmol Vis Sci 44: 4960-4967.
11. Paques M, Simonutti M, Roux MJ, Picaud S, Levavasseur E, et al. (2006) High resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse. Vision Res 46: 1336-1345.
12. Seeliger MW, Beck SC, Pereyra-Munoz N, Dangel S, Tsai JY, et al. (2005) In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res 45: 3512-3519.
13. Brand MG, Granato M, Nüsslein-Volhard C, eds (2002) Keeping and raising zebrafish. Oxford: Oxford University Press. pp 7-38.
14. Lee P, Wang CC, Adamis AP (1998) Ocular neovascularization: an epidemiologic review. Surv Ophthalmol 43: 245-269.
15. Wong TY, Mitchell P (2007) The eye in hypertension. Lancet 369: 425-435.
16. Alvarez Y, Cederlund ML, Cottell DC, Bill BR, Ekker SC, et al. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Dev Biol 7: 114.
17. Li ZY, Possin DE, Milam AH (1995) Histopathology of bone spicule pigmentation in retinitis pigmentosa. Ophthalmology 102: 805-816.
18. Hubert MF, Gerin G, Durand-Cavagna G (1999) Spontaneous ophthalmic lesions in young Swiss mice. Lab Anim Sci 49: 232-240.
19. Pang JJ, Chang B, Hawes NL, Hurd RE, Davisson MT, et al. (2005) Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA). Mol Vis 11: 152-162.
20. Pinto LH, Vitaterna MH, Siepka SM, Shimomura K, Lumayag S, et al. (2004) Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus. Vision Res 44: 3335-3345.
21. Heckenlively JR, Hawes NL, Friedlander M, Nusinowitz S, Hurd R, et al. (2003) Mouse model of subretinal neovascularization with choroidal anastomosis. Retina 23: 518-522.
22. Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A 103: 11282-11287.
23. Lyons BL, Smith RS, Hurd RE, Hawes NL, Burzenski LM, et al. (2006) Deficiency of SHP-1 protein-tyrosine phosphatase in ''viable motheaten'' mice results in retinal degeneration. Invest Ophthalmol Vis Sci 47: 1201-1209.
24. Klein BE, Klein R, Lee KE (1998) Incidence of age-related cataract: the Beaver Dam Eye Study. Arch Ophthalmol 116: 219-225.
25. Hart WE, Goldbaum M, Cote B, Kube P, Nelson MR (1999) Measurement and classification of retinal vascular tortuosity. Int J Med Inform 53: 239-252.
26. Li L, Dowling JE (1997) A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. Proc Natl Acad Sci U S A 94: 11645-11650.
27. Maaswinkel H, Riesbeck LE, Riley ME, Carr AL, Mullin JP, et al. (2005) Behavioral screening for nightblindness mutants in zebrafish reveals three new loci that cause dominant photoreceptor cell degeneration. Mech Ageing Dev 126: 1079-1089.
28. Curcio CA, Johnson M, Huang JD, Rudolf M (2009) Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. Prog Retin Eye Res 28: 393-422.