Small plasmids carrying vga(A) or vga(C) genes mediate resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-resistant Staphylococcus aureus ST398 from swine

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 12, 2010, Pages 2692-2693

  Kadlec, Kristina ^a   Pomba, Constança F ^b   Couto, Natacha ^b   Schwarz, Stefan ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

Antimicrobial multiresistance; MRSA; Recombination; Staphylococci; Zoonosis

Indexed keywords

CLINDAMYCIN; DALFOPRISTIN; ENDONUCLEASE; ENZYME; ERYTHROMYCIN; OXACILLIN; PLASMID DNA; TETRACYCLINE; TIAMULIN; VIRGINIAMYCIN M;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; BROTH DILUTION; EXUDATIVE EPIDERMITIS; GENETIC TRANSFORMATION; LETTER; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NOSE SMEAR; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PLASMID; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; SOW (SWINE); VGAA GENE; VGAC GENE;

ANIMALS; ANTI-BACTERIAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; DITERPENES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FEMALE; LINCOSAMIDES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; PLASMIDS; RECOMBINATION, GENETIC; STAPHYLOCOCCAL INFECTIONS; STREPTOGRAMIN GROUP A; SWINE; SWINE DISEASES; ZOONOSES;

EID: 78149479665     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq365     Document Type: Letter

References (6)

1. Pomba C, Couto N, Cartaxeiro C et al. High frequency of clindamycin-associated resistance among MRSA CC398 from breeding swine herds in Portugal. In: Abstracts of the ASM Conference on Methicillin-resistant Staphylococci in Animals: Veterinary and Public Health Implications, London, 2009. Abstract 19A, p. 34. American Society for Microbiology, Washington, DC, USA.
2. Pomba C, Baptista F, Couto N et al. Methicillin-resistant Staphylococcus aureus CC398 isolates with indistinguishable ApaI restriction patterns in colonized and infected pigs and humans. J Antimicrob Chemother 2010; 65: 2479-81.
3. Lüthje P, Schwarz S. Antimicrobial resistance of coagulase-negative staphylococci from bovine subclinical mastitis with particular reference to macrolide-lincosamide resistance phenotypes and genotypes. J Antimicrob Chemother 2006; 57: 966-9.
4. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals-Third Edition: Approved Standard M31-A3. CLSI, Wayne, PA, USA, 2008.
5. Gentry DR, McCloskey L, Gwynn MN et al. Genetic characterization of Vga ABC proteins conferring reduced susceptibility of Staphylococcus aureus to pleuromutilins. Antimicrob Agents Chemother 2008; 52: 4507-9.
6. Kadlec K, Schwarz S. Identification of a novel ABC transporter gene, vga(C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Antimicrob Agents Chemother 2009; 53: 3589-91.