Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice

Cell Stress and Chaperones

Volumn 15, Issue 6, 2010, Pages 851-863

  Christensen, Jane H ^a,b   Nielsen, Marit N ^a   Hansen, Jakob ^a   Füchtbauer, Annette ^b   Füchtbauer, Ernst Martin ^b   West, Mark ^b   Corydon, Thomas J ^b   Gregersen, Niels ^a   Bross, Peter ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Chaperonin 10; Chaperonin 60; Embryonic development; Gene knockout techniques; Insertional mutagenesis; OmniBank

Indexed keywords

CHAPERONE; CHAPERONIN; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 60; PORIN; TUBULIN; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; ESSENTIAL GENE; FEMALE; GENE INACTIVATION; GENE INSERTION; GESTATIONAL AGE; HETEROZYGOSITY; HOMOZYGOSITY; HSPD1 GENE; HSPE1 GENE; LETHALITY; LIVER; MALE; MOUSE; NIDATION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; TISSUE LEVEL; WESTERN BLOTTING; WILD TYPE;

ANIMALS; CHAPERONIN 10; CHAPERONIN 60; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FETAL DEATH; GENES, LETHAL; GENOTYPE; HETEROZYGOTE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUTAGENESIS, INSERTIONAL; PHENOTYPE; PORINS; SPASTIC PARAPLEGIA, HEREDITARY; TUBULIN;

MAMMALIA; MUS;

EID: 78149471001     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-010-0194-x     Document Type: Article

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