RNase 7 protects healthy skin from staphylococcus aureus colonization

Journal of Investigative Dermatology

Volumn 130, Issue 12, 2010, Pages 2836-2838

  Simanski, Maren ^a   Dressel, Stefanie ^a   Gläser, Regine ^a   Harder, Jürgen ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEASE; RIBONUCLEASE 7; UNCLASSIFIED DRUG;

BACTERIAL COLONIZATION; BACTERICIDAL ACTIVITY; ENZYME ANALYSIS; HOST RESISTANCE; HUMAN; INFECTION RESISTANCE; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN PROTECTION; STAPHYLOCOCCUS AUREUS;

EID: 78149469147     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.217     Document Type: Letter

References (7)

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2. Harder J, Schröder JM (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 277: 46779-84
3. Kisich KO, Howell MD, Boguniewicz M et al. (2007) The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3. J Invest Dermatol 127:2368-80
4. Köten B, Simanski M, Gläser R et al. (2009) RNase 7 contributes to the cutaneous defense against Enterococcus faecium. PLoS One 4:e6424
5. Miller LG, Kaplan SL (2009) Staphylococcus aureus: a community pathogen. Infect Dis Clin North Am 23:35-52
6. Noble WC (1998) Skin bacteriology and the role of Staphylococcus aureus in infection. Br J Dermatol 139(Suppl 53):9-12
7. Zanger P, Holzer J, Schleucher R et al. (2009) Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylo-coccus aureus infection of the skin. J Infect Dis 200:1907-15