Therapeutic misadventure with paracetamol in children

Indian Journal of Pharmacology

Volumn 42, Issue 6, 2010, Pages 412-415

  Shivbalan, So ^a   Sathiyasekeran, Malathi ^a   Thomas, Kuruvilla ^a  

^a Sundaram Medical Foundation   (India)

Author keywords

Acetaminophen; N acetylcysteine; NAC; paracetamol; poisoning; therapeutic misadventure; toxicity

Indexed keywords

ACETYLCYSTEINE; PARACETAMOL;

ANAMNESIS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONCENTRATION RESPONSE; FEMALE; HUMAN; INFANT; INTOXICATION; LIVER INJURY; LOADING DRUG DOSE; MALE; PRESCHOOL CHILD; RECOMMENDED DRUG DOSE; TREATMENT RESPONSE;

EID: 78149396755     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.71894     Document Type: Article

References (14)

1. Roberts EA. Drug induced liver disease. In: Suchy FJ, Sokol RJ, Balistreri WF, editors. Liver disease in children. 3rd ed. USA: Cambridge university press; 2007. p. 478-512.
2. Miller RP, Roberts RJ, Fischer LJ. Acetaminophen elimination kinetics in neonates, children and adults. Clin Pharmacol Ther 1976;19:284-94.
3. Mahadevan SB, McKiernan PJ, Davies P, Kelly DA. Paracetamol induced hepatotoxicity. Arch Dis Child 2006;91:598-603.
4. Kelly DA, Mayer D. Liver Transplantation. In: Kelly DA, editor. Diseases of the Liver and Biliary System in Children. 2nd ed. USA: Blackwell Publishing Ltd; 2004. p. 378-401.
5. Alander SW, Dowd MD, Bratton SL, Kearns GL. Pediatric acetaminophen overdose: Risk factors associated with hepatocellular injury. Arch Pediatr Adolesc Med 2000;154:346-50.
6. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: Hepatoxicity after multiple doses in children. J Pediatr 1998;132:22-7.
7. Paracetamol use. A Position Statement of the New South Wales (NSW) Therapeutic Advisory Group Inc. December 2008. Available from: http://www.ciap.health.nsw.gov.au/nswtag/publications/posstats/ Paracetamol231208.pdf [last accessed on 2009 Jan 16].
8. Rumack BH, Matthew M. Acetaminophen poisoning and toxicity. Pediatrics 1975;55:871-6.
9. Daly FF, Fountain JS, Murray L, Graudins A, Buckley NA; Panel of Australian and New Zealand clinical toxicologists. Guidelines for the management of paracetamol poisoning in Australia and New Zealand - explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Med J Aust 2008;188:296-301.
10. Kearns GL, Leeder JS, Wasserman GS. Acetaminophen intoxication during treatment: What you don't know can hurt you. Clin Pediatr 2000;39:133-44.
11. IPCS (international programme on chemical safety) / CEC Evaluation of Antidotes Series. Antidotes for poisoning by paracetamol. Available from: http://www.inchem.org/documents/antidote/antidote/ant03.htm [last accessed on 2008 Dec 10].
12. Singer AJ, Carracio TR, Mofenson HC. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med 1995;26:49-53.
13. Algren DA. Review of N-acetylcysteine for the treatment of acetaminophen (paracetamol) toxicity in pediatrics. Second Meeting of the Subcommittee of the Expert Committee on the Selection and Use of Essential Medicines. Geneva, 29 September to 3 October 2008. Available from: http://www.who.int/selection- medicines/committees/subcommittee/2/acetylcysteine-rev.pdf [last accessed on 2009 Jan 20].
14. Daly FF, Omalley GF, Heard K, Bogdan GM, Dart RC. Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. Ann Emerg Med 2004;44:393-8.