The alcohol metabolite acetaldehyde and psoriasis: Another trigger factor?

Clinical and Experimental Dermatology

Volumn 35, Issue 8, 2010, Pages 923-925

  Farkas, A ^a   Kemeny L ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ACETONE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALPHA5 INTEGRIN; CYCLIN D1; CYTOCHROME P450 2E1; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KERATINOCYTE GROWTH FACTOR RECEPTOR; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; KERATINOCYTE; LETTER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PSORIASIS; SIGNAL TRANSDUCTION; UPREGULATION;

ACETALDEHYDE; ACETONE; ANIMALS; DENDRITIC CELLS; ETHANOL; HUMANS; KERATINOCYTES; LYMPHOCYTES; PSORIASIS; SKIN;

EID: 78149381418     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2010.03866.x     Document Type: Letter

References (5)

1. Saladi RN, Nektalova T, Fox JL. Induction of skin carcinogenicity by alcohol and ultraviolet light. Clin Exp Dermatol 2010; 35: 7-11.
2. Farkas A, Kemeny L. Psoriasis and alcohol: is cutaneous ethanol one of the missing links? Br J Dermatol 2010; 162: 711-16.
3. Young CN, Koepke JI, Terlecky LJ et al. Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes. implications for psoriasis and inflammatory skin disease. J Invest Dermatol 2008; 128: 2606-14.
4. Timmons SR, Nwankwo JO, Domann FE. Acetaldehyde activates June/AP-1 expression and DNA binding activity in human oral keratinocytes. Oral Oncol 2002; 38: 281-90.
5. Marcekova Z, Flaig MJ, Kekus M et al. The potential role of c-June activation in patients with cutaneous lichen planus. Exp Dermatol 2010; 19: 74-80.