Comparison of analgesic effects of nimesulide, paracetamol, and their combination in animal models

Indian Journal of Pharmacology

Volumn 42, Issue 6, 2010, Pages 354-357

  Ahmed, Mushtaq ^a   Upadhyaya, Prerna ^a   Seth, Vikas ^a  

^a GANDHI MEDICAL COLLEGE   (India)

Author keywords

Analgesic effects; nimesulide; paracetamol

Indexed keywords

GUM ARABIC; NIMESULIDE; PARACETAMOL;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MONOTHERAPY; NONHUMAN; PAIN; RAT; SINGLE DRUG DOSE;

EID: 78149371973     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.71913     Document Type: Article

References (18)

1. Burke A, Smyth EM, Fitzgerald GA. Analgesic-antipyretic agents; Pharmacotherapy of gout. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman's The Pharmacological basis of therapeutics. 11th ed. New York: Mcgraw-Hill; 2006. p. 671-716.
2. Pharmacological and therapeutic rationale of combination of Nimesulide and paracetamol: Company manuscript. Emcure Pharmaceuticals Pvt. Ltd.
3. Kulkarni SK, Jain NK. Is there any rationale for Nimesulide and paracetamol combination? Indian J Pharmacol 1999;31:444-5.
4. Famaey JP. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 by nimesulide: An overview. Inflamm Res 1997;46:437-46.
5. Rabasseda X. Nimesulide: A selective cyclooxygenase-2 inhibitor antiinfammatory drug. Drugs Today 1996;32:1-23. (Pubitemid 26330161)
6. Rabasseda X. Safety profile of nimesulide: Ten years of clinical experience. Drugs Today 1997;33:41-50.
7. Bianchi M, Martucci C, Ferrario P, Franchi S, Sacerdote P. Increased Tumor Necrosis Factor α and Prostaglandin E2 Concentrations in the Cerebrospinal Fluid of Rats with Inflammatory Hyperalgesia: The Effects of Analgesic Drugs. Anesth Analg 2007;104:949-54.
8. Kalra BS, Shalini, Chaturvedi S, Tayal V, Gupta U. Evaluation of gastric tolerability, antinociceptive and antiinflammatory activity of combination NSAIDs in rats. Indian J Dent Res 2009;20:418-22. Available from: http://www.ijdr.in/text.asp?2009/20/4/418/59439. [Last cited on 2010 Jul 13].
9. rd ed. New York: Springer; 2008. p. 1020-1.
10. Patil CS, Kulkarni SK. The morphine sparing effects of physostigmine. Exp Clin Pharmacol 1999;21:523-7.
11. Ghosh MN. Fundamentals of Experimental Pharmacology. 3rd ed. Kolkata: Hilton and Company; 2005. p. 176.
12. Gupta SK, Velpandian T, Mathur P, Sengupta S. Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: Correlation with pharmacokinetic profile of nimesulide. Pharmacology 1998;56:137-43.
13. Engelhardt G, Mauz AB, Pairet M. Role of caffeine in combined analgesic drugs from the point of view of experimental pharmacology. Arzneimittel Forschung 1997;47:917-27.
14. Bach PH, Berndt WO, Delzell E, Dubach U, Finn WF, Fox JM, et al. A safety assessment of fixed combinations of paracetamol and acetyl salicylic acid co formulated with caffeine. Ren Fail 1995;20:749-62.
15. Gulhati CM. Irrational fixed dose drug combinations: A sordid story of profits before patients. Vol. 11. Issues in Medical Ethics 1. Available from: http://www.issuesinmedicalethics.org/111ed005.html [Last cited on 2003].
16. Raffa RB. Pharmacology of oral combination analgesics: Rational therapy for pain. J Clin Pharm Ther 2001;26:257-64.
17. Gautam CS, Aditya S. Irrational drug combinations: Need to sensitize undergraduates. Indian J Pharmacol 2006;38:167-70.
18. Gautam CS, Saha L. Fixed dose drug combinations (FDCs): Rational or Irrational: A view point. Br J Clin Pharmacol 2008;65:795-6.