Development and characterization of " push-pull" sampling device with fast reaction quenching coupled to high-performance liquid chromatography for pharmaceutical process analytical technologies

Journal of Chromatography A

Volumn 1217, Issue 48, 2010, Pages 7471-7477

  Chisolm, Claire N ^a   Evans, Charles R ^a   Jennings, Colin ^a   Black, Will A ^b   Antosz, Frederick J ^c   Qiang, Yangqiao ^c   Diaz, Angel R ^c   Kennedy, Robert T ^a,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b KALAMAZOO COLLEGE   (United States)

^c PFIZER INC   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Automation; High performance liquid chromatography (HPLC); Online sampling; Process analytical technology (PAT); Sample preparation

Indexed keywords

BASE-CATALYZED HYDROLYSIS; BULK SAMPLES; COMPLETELY-MIXED; CONCENTRIC TUBE; EXPECTED DELAY; FAST REACTION; FINITE ELEMENT MODELS; INNER TUBES; OFFSET DISTANCES; ON-LINE SAMPLING; PASSIVE MIXING; PERIODIC SAMPLING; PHARMACEUTICAL PROCESS; PROCESS ANALYTICAL TECHNOLOGY; QUENCHANTS; REACTION MIXTURE; REACTION VESSEL; REAL TIME MONITORING; RESPONSE TIME; SAMPLE PREPARATION; SAMPLING DEVICES; SAMPLING RATES; SAMPLING SYSTEMS;

BLOOD VESSELS; CHROMATOGRAPHY; DRUG PRODUCTS PLANTS; FINITE ELEMENT METHOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; REACTION RATES;

SAMPLING;

ACETYLSALICYLIC ACID;

ARTICLE; AUTOMATION; CAPILLARY DENSITY; CHEMICAL REACTION; CONTROLLED STUDY; DILUTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONPHOTOCHEMICAL QUENCHING; ONLINE SYSTEM; PRIORITY JOURNAL; PROCESS TECHNOLOGY; RESPONSE TIME; SAMPLING; VISCOSITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EQUIPMENT DESIGN; TECHNOLOGY, PHARMACEUTICAL;

EID: 78149359507     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.09.066     Document Type: Article

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