Antitumor activity of imidazole derivatives: Dacarbazine and the new alkylating agent imidazene (Review)

Pharmaceutical Chemistry Journal

Volumn 44, Issue 4, 2010, Pages 175-182

  Iradyan, M A ^a   Iradyan, N S ^a   Stepanyan, G M ^a   Arsenyan, F G ^b   Garibdzhanyan, B T ^a,b  

^a Scientific and Technological Center of Organic and Pharmaceutical Chemistry   (Armenia)

^b INSTITUTE OF ORGANIC CHEMISTRY   (Armenia)

Author keywords

antitumor activity; chemotherapy; dacarbazine; imidazene; mechanism of biochemical action; phenyltriazenes; substituted triazenoimidazolcarboxamides

Indexed keywords

1 (4 CARBOMETHOXYPHENYL) 3,3 DIMETHYLTRIAZENE; 1 (BETA DEXTRO RIBOFURANOSYL) 5 (3,3 DIMETHYLTRIAZENO 1)IMIDAZOL 4 CARBOXAMIDE; 1 4 (3,3 DIMETHYLTRIAZENO 1)BENZOIC ACID; 4(5) DIAZOIMIDAZOL 5(4) CARBOXAMIDE; 4(5)(3 MONOALKYLTRIAZENO 1)IMIDAZOL 5(4) CARBOXAMIDE DERIVATIVE; ALKYLATING AGENT; BLEOMYCIN; CARMUSTINE; DACARBAZINE; DIPROPYLTRIAZENOIMIDAZOLCARBOXAMIDE; DOXORUBICIN; FLUOROURACIL; IMIDAZENE; IMIDAZOL 5 CARBOXAMIDE; IMIDAZOLE DERIVATIVE; METHYLDACARBAZINE; PHENYLTRIAZENE DERIVATIVE; RNA; SARCOLYSIN; TRIAZENE DERIVATIVE; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; BACTERICIDAL ACTIVITY; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CARCINOGENICITY; COLON CANCER; DOSE RESPONSE; DRUG DECOMPOSITION; DRUG MECHANISM; DRUG STABILITY; DRUG SYNTHESIS; DRUG TARGETING; HODGKIN DISEASE; HUMAN; LEUKEMIA; LEWIS CARCINOMA; LYMPHOSARCOMA; MAXIMUM TOLERATED DOSE; MELANOMA; OSTEOSARCOMA; PHOTOLYSIS; PHYSICAL CHEMISTRY; REVIEW; SARCOMA;

EID: 78149358547     PISSN: 0091150X     EISSN: 15739031     Source Type: Journal    
DOI: 10.1007/s11094-010-0425-6     Document Type: Review

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