Subtrochanteric femoral insufficiency fractures related to the use of long-term bisphosphonates: A pictorial review

Emergency Radiology

Volumn 17, Issue 6, 2010, Pages 511-515

  Venkatanarasimha, Nanda ^a   Miles, Gemma ^a   Suresh, Priya ^a  

^a DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

Bisphosphonates; Bone scan; CT; MRI; Plain radiographs

Indexed keywords

ALENDRONIC ACID; ANTINEOPLASTIC AGENT; PREDNISOLONE;

ADULT; AGED; BONE BIOPSY; BONE SCINTISCANNING; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FALLING; FEMALE; FEMUR SUBTROCHANTERIC FRACTURE; FRAGILITY FRACTURE; HIP PAIN; HUMAN; INTRAMEDULLARY NAILING; LONG TERM CARE; LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOPOROSIS; PELVIS RADIOGRAPHY; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS;

AGED; DIAGNOSTIC IMAGING; DIPHOSPHONATES; FEMALE; FEMORAL FRACTURES; HUMANS; MALE; MIDDLE AGED;

EID: 78149357518     PISSN: 10703004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10140-010-0890-y     Document Type: Review

References (20)

1. DM Black SR Cummings DB Karpf JA Cauley DE Thompson MC Nevitt DC Bauer HK Genant WL Haskell R Marcus SM Ott JC Torner SA Quandt TF Reiss KE Ensrud 1996 Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group Lancet 348 1535 1541 1:CAS:528:DyaK2sXisFCktQ%3D%3D 10.1016/S0140-6736(96)07088-2 8950879 (Pubitemid 26411651)
2. CV Odvina JE Zerwekh DS Rao N Maalouf FA Gottschalk CY Pak 2005 Severely suppressed bone turnover: potential complication of alendronate therapy J Clic Endocrinol Metab 90 1294 1301 1:CAS:528:DC%2BD2MXisVOhsr0%3D 10.1210/jc.2004-0952 (Pubitemid 40463979)
3. JS Koh SK Goh MA Png EB Kwek TS Howe 2010 Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture? J Orthop Trauma 24 75 81 10.1097/BOT.0b013e3181b6499b 20101130
4. JD Currey 1984 Effects of differences in mineralisation on the mechanical properties of bone Phil Trans R Soc Lond Biol Sci 304 509 518 1:STN:280:DyaL2c7ksFWnug%3D%3D 10.1098/rstb.1984.0042
5. N Wasserman J Yerramshetty O Akkus 2005 Microcracks colocalize within highly mineralised regions of cortical bone tissue Eur J Morphol 42 43 51 10.1080/09243860500095471 16123023 (Pubitemid 41074377)
6. T Mashiba S Mori DB Burr S Komatsubara Y Cao T Manabe H Norimatsu 2005 The effects of suppressed bone remodelling by bisphosphonates on microdamage accumulation and degree of mineralisation in the cortical bone of dog rib J Bone Miner Metab 23 Suppl 36 42 1:CAS:528:DC%2BD2MXmvVynur0%3D 10.1007/BF03026321 15984412
7. KE Ensrud EL Barrett-Connor A Schwartz AC Santora DC Bauer S Suryawanshi A Feldstein WL Haskell MC Hochberg JC Torner A Lombardi DM Black 2004 Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension J Bone Miner Res 19 1259 1269 1:CAS:528:DC%2BD2cXntFGqur0%3D 10.1359/JBMR.040326 15231012 (Pubitemid 41094366)
8. DM Black AV Schwartz KE Ensrud JA Cauley S Levis SA Quandt S Satterfield RB Wallace, et al. 2006 Effects of continuing of stopping alendronate after 5 years of treatment: the fracture intervention trial long-term extension (FLEX): a randomised trial JAMA 296 2968 2969 10.1001/jama.296.24.2927 (Pubitemid 46021497)
9. MP Whyte D Wenkert KL Clemens WH McAllister S Mumm 2003 Bisphosphonate-induced osteopetrosis N Engl J Med 349 457 463 1:CAS:528:DC%2BD3sXms1Ogsrc%3D 10.1056/NEJMoa023110 12890844 (Pubitemid 36910024)
10. G Boivin PJ Meunier 2002 Changes in bone remodelling rate influence the degree of mineralization of bone Connect tissue Res 43 535 537 1:STN:280:DC%2BD38jislarsg%3D%3D 12489211
11. O Akkus A Polyakova-Akkus F Adar MB Schaffler 2003 Aging and microstructural compartments in human compact bone J Bone Miner Res 18 1012 1019 1:CAS:528:DC%2BD3sXkslOhsb4%3D 10.1359/jbmr.2003.18.6.1012 12817753 (Pubitemid 37294937)
12. E Richer M Lewis C Odvina MA Vasquez BJ Smith RD Peterson, et al. 2005 Reduction in normalized bone elasticity long-term bisphosphonate treatment as measured by ultrasound critical angle reflectometry Osteoporosis International 16 1384 1392 1:CAS:528:DC%2BD2MXhtFGlt7fM 10.1007/s00198-005-1848-x 15726294 (Pubitemid 41532091)
13. F Pauwels 1948 Die bedeutung der bauprinzipien des stutz-und bewegungsapparates fur die beanspruchung der rohrenknochen Anat Embryol 114 1 2 10.1007/BF00523553
14. SK Goh KY Yank JS Koh MK Wong SY Chua DT Chua TS Howe 2007 Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution J Bone Joint Surg Br 89 349 353 10.1302/0301-620X.89B3.18146 17356148 (Pubitemid 46563912)
15. AS Neviaser JM Lane BA Lenart F Edobor-Osula DG Lorich 2008 Low-energy femoral shaft fractures associated with alendronate use J Orth Trauma 22 346 350 10.1097/BOT.0b013e318172841c (Pubitemid 351630250)
16. EB Kwek SK Goh JS Koh MA Png TS Howe 2008 An emerging pattern of subtrocahanteric stress fractures: a long-term complication of alendronate therapy? Injury 39 224 231 10.1016/j.injury.2007.08.036 18222447
17. JA Porrino CA Kohl M Taljanovic LF Rogers 2010 Diagnosis of proximal femoral insufficiency fractures in patients receiving bisphosphonate therapy Am J Roentgenol 194 1061 1064 10.2214/AJR.09.3383
18. LA Bush FS Chew 2008 Subtrochanteric femoral insufficiency fracture following bisphosphonate therapy for osseous metastases Radiol Case Rep 3 232
19. M Visekruna D Wilson FE McKiernan 2008 Severely suppressed bone turnover and atypical skeletal fragility J Clin Endocrinol Metab 93 2948 2952 1:CAS:528:DC%2BD1cXpvVOmurg%3D 10.1210/jc.2007-2803 18522980
20. Tilstone C (2009). Drug safety update. MRHA and CHM 2; issue 8:8