Atorvastatin induces apoptosis in vitro and slows growth of tumor xenografts but not polyp formation in min mice

Digestive Diseases and Sciences

Volumn 55, Issue 11, 2010, Pages 3086-3094

  Huang, Emina H ^a   Johnson, Laura A ^b   Eaton, Kathryn ^c   Hynes, Mark J ^b   Carpentino, Joseph E ^a   Higgins, Peter D R ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Apoptosis; Chemoprevention; Colon cancer; Statins

Indexed keywords

ATORVASTATIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL STRAIN HCT116; COLON CANCER; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; POLYP; PRENYLATION; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; COLONIC NEOPLASMS; COLONIC POLYPS; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, NUDE; PYRROLES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78149357224     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1157-x     Document Type: Article

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