Validation of capillary electrophoresis method for determination of N-methylpyrrolidine in cefepime for injection

Journal of Chromatographic Science

Volumn 48, Issue 10, 2010, Pages 830-834

  Prasanna, S John ^a,b   Sharma, Hemant Kr ^a   Mukkanti, K ^b   Kumar, V Jagadeesh ^a   Raja, G ^a   Sivakumaran, M ^a  

^a Aurobindo Pharma Ltd   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78149346934     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/48.10.830     Document Type: Article

References (10)

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3. Inert ingredient permitted for use in nonfood use pesticide products. Office of prevention pesticides and toxic substances, United States environmental protection agency, Washington, DC, 2009. (http://www.epa.gov/ opprd001/inerts/inert-nonfooduse.pdf).
4. United States Pharmacopeial Convention. USP monograph: Cefepime for injection, USP 32 NF27, 2009, p. 1833
5. Determination of N-methylpyrrolidine in cefepime using a reagent free ion chromatography system. Dionex application notes 199. (http://www.dionex.com/ enus/webdocs/67389-AN199-IC-NMP-Cefepime-03Jun08-LPN2005.pdf)
6. G. Chen, G. Liu, F. Qin, and Y. Wang. A simple and sensitive method for determination of N-methylpyrrolidine in cefepime and its preparation. J. Pharm. Biomed. Anal. 33: 797-801 (2003).
7. J.L. Beckers and P. Bocek. The preparation of background electrolytes in capillary zone electrophoresis: Golden rules and pitfalls. Electrophoresis 24: 518-535 (2003). (Pubitemid 36267188)
8. International Conference on Harmonization of Technical Requirement for Registration of Pharmaceuticals for Human use. ICH harmonized tripartite guideline. Validation of analytical procedures text and methodology Q2 (R1), 2005.
9. H. Liu and V.B. Sunderland. Determination of N-methylpyrrolidine in cefepime for injection by capillary electrophoresis with indirect UV detection. Chromatographia 59: 653-657 (2004). (Pubitemid 38757162)
10. J.O. Fubara and R.E. Notari. Influence of pH, temperature and buffers on cefepime degradation kinetics and stability predictions in aqueous solutions. J. Pharm. Sci. 87:1572-1576 (1998).