Platelet function following administration of a novel formulation of intravenous diclofenac sodium versus active comparators: A randomized, single dose, crossover study in healthy male volunteers

Journal of Clinical Anesthesia

Volumn 22, Issue 7, 2010, Pages 510-518

  Bauer, Kenneth A ^a   Gerson, William ^b   Wright IV, Curtis ^c,d   Wang, Jianyuan ^c,d   McNicol, Ewan ^e   Lanier, Ryan K ^c,d   Kramer, William ^f   Carr, Daniel B ^c,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Comprehensive Phase One ^*  (United States)

^c Javelin Pharmaceuticals Inc   (United States)

^d Hospira Inc   (United States)

^e Analgesic Trial Design   (United States)

^f Kramer Consulting LLC   (United States)

Author keywords

COX 1 COX 2; Diclofenac; Multimodal; Nonsteroidal anti inflammatory drugs; Platelets; Postoperative

Indexed keywords

ACETYLSALICYLIC ACID; DICLOFENAC; DYLOJECT; KETOROLAC TROMETAMOL; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SAFETY; FLATULENCE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; ASPIRIN; BLOOD PLATELETS; COLLAGEN; CROSS-OVER STUDIES; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; EPINEPHRINE; HUMANS; INJECTIONS, INTRAVENOUS; KETOROLAC; MALE; MIDDLE AGED; PLATELET COUNT; PLATELET FUNCTION TESTS; TIME FACTORS; YOUNG ADULT;

EID: 78149286453     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinane.2009.12.011     Document Type: Article

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