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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 7116-7119

N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators

(6) Thewlis, Kevin M a Aldegheri, Laura a Harries, Mark H a Mookherjee, Claudette a Oliosi, Beatrice a Ward, Simon E a

a GLAXOSMITHKLINE (United Kingdom)

Author keywords

AMPA; Modulators; Receptor; Synthesis

Indexed keywords

4 BROMONITROSTYRENE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMPA RECEPTOR; CENTRAL NERVOUS SYSTEM AGENTS; GLYCINE; PARAFORMALDEHYDE; POTASSIUM CHANNEL HERG; PYRROLIDINE DERIVATIVE; STYRENE DERIVATIVE; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CENTRAL NERVOUS SYSTEM; ETHER-A-GO-GO POTASSIUM CHANNELS; FURANS; HUMANS; PROTEIN ISOFORMS; PYRROLIDINES; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 78149284726 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.09.062 Document Type: Article

Times cited : (10)

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