Impact of routine fluconazole prophylaxis for premature infants with birth weights of less than 1250 grams in a developing country

Pediatric Infectious Disease Journal

Volumn 29, Issue 11, 2010, Pages 1050-1052

  Rueda, Kathia ^a   Moreno, Maria Teresa ^a   Espinosa, Manuel ^a   Sáez Llorens, Xavier ^a  

^a Hospital Del Niño Ciudad de Panamá   (United States)

Author keywords

Fluconazole prophylaxis; neonatal candidiasis; neonatal fungal infection; neonatal prophylaxis

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; CASPOFUNGIN; FLUCONAZOLE;

ARTICLE; BIRTH WEIGHT; CANDIDA; CANDIDA ALBICANS; CANDIDA FUMATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CANDIDIASIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; SEPSIS; SYSTEMIC MYCOSIS;

EID: 78149280103     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181e9dea2     Document Type: Article

References (21)

1. Benjamin DK Jr, Stoll BJ, Fanaroff AA, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006;117:84-92.
2. Cotten CM, McDonald S, Stoll B, et al. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006;118:717-722.
3. Makhoul IR, Sujov P, Smolkin T, et al. Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: a national survey. Pediatrics. 2002;109:34-39.
4. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285-291.
5. Manzoni P, Farina D, Leonessa M, et al. Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization. Pediatrics. 2006;118:2359-2364. (Pubitemid 46397574)
6. Kaufman D, Boyle R, Hazen KC, et al. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med. 2001;345:1660-1666.
7. Benjamin DK Jr, DeLong ER, Steinbach WJ, et al. Empirical therapy for neonatal candidemia in very low birth weigh infants. Pediatrics. 2003;112:543-547.
8. Manzoni P, Stolfi H, Pungi L, et al. A multicenter, randomized trial of prophylactic fluconazol in preterm neonates. N Engl J Med. 2007;356:2483-2495.
9. Uko S, Soghier LM, Vega M, et al. Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants. Pediatrics. 2006;117:1243-1252.
10. Bertini G, Perugi S, Dani C, et al. Fluconazole prophylaxis prevents invasive fungal infection in high-risk, very low birth weight infants. J Pediatr. 2005;147:162-165.
11. Long SS, Stevenson DK. Reducing Candida infections during neonatal intensive care: management choices, infection control, and fluconazole prophylaxis. J Pediatr. 2005;147:135-141.
12. McGuire W, Clerihew L, Austin N. Prophylactic intravenous antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2004: CD003850.
13. McCrossan B, McHenry E, O'Neill F, et al. Selective fluconazol prophylaxis in high-risk babies to reduce invasive fungal infection. Arch Dis Child Fetal Neonatal Ed. 2007;92:F454-F458.
14. Kaufman D, Boyle R, Hazen KC, et al. Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J Pediatr. 2005;147:172-179.
15. Healy CM, Baker CJ, Zaccaria E, et al. Impact of fluconazole prophylaxis on rate and outcome of invasive candidiasis in a neonatal intensive care unit. J Pediatr. 2005;147:166-171.
16. Healy CM, Campbell JR, Zaccaria E, et al. Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazole resistant Candida species. Pediatrics. 2008;121:703-710.
17. Manzoni P, Ariso R, Mostert M, et al. Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study. Pediatrics. 2006;117: e22-e32.
18. Aziz M, Patel AL, Losavio J, et al. Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants. Pediatr Infect Dis J. 2010;29:352-356.
19. Archivos Clínicos y de Laboratorio. Boletines Estadísticos del Hospital del Nino de Panama, 2001-2009.
20. Fanaroff AA. Fluconazole for the prevention of fungal infections: get ready, get set, caution. Pediatrics. 2006;117:214-215.
21. Neely MN, Schreiber JR. Fluconazole prophylaxis in the very low birth weight infant: not ready for prime time. Pediatrics. 2001;107:404-405.