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Volumn 13, Issue 6, 2010, Pages 656-661

Immune modulating effects of β-glucan

Author keywords

cancer; immune function; infection; nutrition

Indexed keywords

BETA GLUCAN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 18;

EID: 78149279932     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32833f1afb     Document Type: Review
Times cited : (77)

References (55)
  • 1
    • 0030029478 scopus 로고    scopus 로고
    • Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18)
    • Thornton BP, Vetvicka V, Pitman M, et al. Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 1996;156:1235-1246.
    • (1996) J. Immunol. , vol.156 , pp. 1235-1246
    • Thornton, B.P.1    Vetvicka, V.2    Pitman, M.3
  • 2
    • 0036658734 scopus 로고    scopus 로고
    • Human monocyte scavenger receptors are pattern recognition receptors for (1 → 3)-beta-D-glucans
    • Rice PJ, Kelley JL, Kogan G, et al. Human monocyte scavenger receptors are pattern recognition receptors for (1 → 3)-beta-D-glucans. J Leukoc Biol 2002;72:140-146.
    • (2002) J. Leukoc Biol. , vol.72 , pp. 140-146
    • Rice, P.J.1    Kelley, J.L.2    Kogan, G.3
  • 3
    • 0032555519 scopus 로고    scopus 로고
    • A novel carbohydrate-glycosphingolipid interaction between a beta-(1 → 3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes
    • Zimmerman JW, Lindermuth J, Fish PA, et al. A novel carbohydrate- glycosphingolipid interaction between a beta-(1 → 3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes. J Biol Chem 1998;273:22014-22020.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22014-22020
    • Zimmerman, J.W.1    Lindermuth, J.2    Fish, P.A.3
  • 4
    • 0035817818 scopus 로고    scopus 로고
    • Immune recognition. A new receptor for beta-glucans
    • Brown GD, Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001;413:36-37.
    • (2001) Nature , vol.413 , pp. 36-37
    • Brown, G.D.1    Gordon, S.2
  • 5
  • 6
    • 33746439003 scopus 로고    scopus 로고
    • The effect of PGG-beta-glucan on neutrophil chemotaxis in vivo
    • LeBlanc BW, Albina JE, Reichner JS. The effect of PGG-beta-glucan on neutrophil chemotaxis in vivo. J Leukoc Biol 2006;79:667-675.
    • (2006) J. Leukoc Biol. , vol.79 , pp. 667-675
    • LeBlanc, B.W.1    Albina, J.E.2    Reichner, J.S.3
  • 7
    • 0036885015 scopus 로고    scopus 로고
    • Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesion
    • Xia Y, Borland G, Huang J, et al. Function of the lectin domain of Mac-1/complement receptor type 3 (CD11b/CD18) in regulating neutrophil adhesion. J Immunol 2002;169:6417-6426.
    • (2002) J. Immunol. , vol.169 , pp. 6417-6426
    • Xia, Y.1    Borland, G.2    Huang, J.3
  • 8
    • 33746190826 scopus 로고    scopus 로고
    • Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Sykphosphatidylinositol 3-kinase pathway
    • Li B, Allendorf DJ, Hansen R, et al. Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Sykphosphatidylinositol 3-kinase pathway. J Immunol 2006;177:1661-1669.
    • (2006) J. Immunol. , vol.177 , pp. 1661-1669
    • Li, B.1    Allendorf, D.J.2    Hansen, R.3
  • 9
    • 70450224661 scopus 로고    scopus 로고
    • Complement receptor 3, not • Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles
    • There has been some controversy about the relative importance of various receptors on the immune response to β-glucan. This study showed that phagocytosis of β-glucan by neutrophils was completely dependent on complement receptor 3 and not dectin-1. This study provides support for a dissimilar response in recognition of β-glucan among species
    • van Bruggen R, Drewniak A, Jansen M, et al. Complement receptor 3, not • Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles. Mol Immunol 2009;47:575-581. There has been some controversy about the relative importance of various receptors on the immune response to β-glucan. This study showed that phagocytosis of β-glucan by neutrophils was completely dependent on complement receptor 3 and not dectin-1. This study provides support for a dissimilar response in recognition of β-glucan among species.
    • (2009) Mol. Immunol. , vol.47 , pp. 575-581
    • Van Bruggen, R.1    Drewniak, A.2    Jansen, M.3
  • 10
    • 34848905092 scopus 로고    scopus 로고
    • Macrophage scavenger receptors and host-derived ligands
    • Pluddemann A, Neyen C, Gordon S. Macrophage scavenger receptors and host-derived ligands. Methods 2007;43:207-217.
    • (2007) Methods , vol.43 , pp. 207-217
    • Pluddemann, A.1    Neyen, C.2    Gordon, S.3
  • 11
    • 0037449795 scopus 로고    scopus 로고
    • Pneumocystis carinii cell wall betaglucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide- mediated mechanism
    • Hahn PY, Evans SE, Kottom TJ, et al. Pneumocystis carinii cell wall betaglucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. J Biol Chem 2003;278:2043-2050.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2043-2050
    • Hahn, P.Y.1    Evans, S.E.2    Kottom, T.J.3
  • 12
    • 20044381138 scopus 로고    scopus 로고
    • Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factorkappaB-dependent mechanisms
    • Evans SE, Hahn PY, McCann F, et al. Pneumocystis cell wall beta-glucans stimulate alveolar epithelial cell chemokine generation through nuclear factorkappaB-dependent mechanisms. Am J Respir Cell Mol Biol 2005;32:490-497.
    • (2005) Am. J. Respir. Cell. Mol. Biol. , vol.32 , pp. 490-497
    • Evans, S.E.1    Hahn, P.Y.2    McCann, F.3
  • 13
    • 33751530922 scopus 로고    scopus 로고
    • Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1, 6-long glycoside side-chain-branched beta-glucan
    • Sato T, Iwabuchi K, Nagaoka I, et al. Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1, 6-long glycoside side-chain-branched beta-glucan. J Leukoc Biol 2006;80:204-211.
    • (2006) J. Leukoc Biol. , vol.80 , pp. 204-211
    • Sato, T.1    Iwabuchi, K.2    Nagaoka, I.3
  • 15
    • 18844412640 scopus 로고    scopus 로고
    • The human beta-glucan receptor is widely expressed and functionally equivalent to murine dectin-1 on primary cells
    • Willment JA, Marshall AS, Reid DM, et al. The human beta-glucan receptor is widely expressed and functionally equivalent to murine dectin-1 on primary cells. Eur J Immunol 2005;35:1539-1547.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1539-1547
    • Willment, J.A.1    Marshall, A.S.2    Reid, D.M.3
  • 16
    • 65249187409 scopus 로고    scopus 로고
    • Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus
    • Werner JL, Metz AE, Horn D, et al. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol 2009;182:4938-4946.
    • (2009) J. Immunol. , vol.182 , pp. 4938-4946
    • Werner, J.L.1    Metz, A.E.2    Horn, D.3
  • 17
    • 77953786116 scopus 로고    scopus 로고
    • Immunostimulatory properties of a polysaccharide isolated from Astraeus hygrometricus
    • Mallick SK, Maiti S, Bhutia SK, Maiti TK. Immunostimulatory properties of a polysaccharide isolated from Astraeus hygrometricus. J Med Food 2010;13:665-672.
    • (2010) J. Med. Food , vol.13 , pp. 665-672
    • Mallick, S.K.1    Maiti, S.2    Bhutia, S.K.3    Maiti, T.K.4
  • 18
    • 33846963844 scopus 로고    scopus 로고
    • Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    • Saijo S, Fujikado N, Furuta T, et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol 2007;8:39-46.
    • (2007) Nat. Immunol. , vol.8 , pp. 39-46
    • Saijo, S.1    Fujikado, N.2    Furuta, T.3
  • 19
    • 3543039973 scopus 로고    scopus 로고
    • Effects of oat beta-glucan on innate immunity and infection after exercise stress
    • Davis JM, Murphy EA, Brown AS, et al. Effects of oat beta-glucan on innate immunity and infection after exercise stress. Med Sci Sports Exerc 2004;36:1321-1327.
    • (2004) Med. Sci. Sports Exerc. , vol.36 , pp. 1321-1327
    • Davis, J.M.1    Murphy, E.A.2    Brown, A.S.3
  • 20
    • 70349611517 scopus 로고    scopus 로고
    • Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress
    • Murphy EA, Davis JM, Carmichael MD, et al. Benefits of oat beta-glucan and sucrose feedings on infection and macrophage antiviral resistance following exercise stress. Am J Physiol Regul Integr Comp Physiol 2009;297:R1188-R1194.
    • (2009) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.297
    • Murphy, E.A.1    Davis, J.M.2    Carmichael, M.D.3
  • 21
    • 34147164446 scopus 로고    scopus 로고
    • Oat beta-glucan effects on neutrophil respiratory burst activity following exercise
    • Murphy EA, Davis JM, Brown AS, et al. Oat beta-glucan effects on neutrophil respiratory burst activity following exercise. Med Sci Sports Exerc 2007;39:639-644.
    • (2007) Med. Sci. Sports Exerc. , vol.39 , pp. 639-644
    • Murphy, E.A.1    Davis, J.M.2    Brown, A.S.3
  • 22
    • 0032893738 scopus 로고    scopus 로고
    • Antigen-specific response of murine immune system toward a yeast beta-glucan preparation, zymosan
    • Miura T, Ohno N, Miura NN, et al. Antigen-specific response of murine immune system toward a yeast beta-glucan preparation, zymosan. FEMS Immunol Med Microbiol 1999;24:131-139.
    • (1999) FEMS Immunol. Med. Microbiol. , vol.24 , pp. 131-139
    • Miura, T.1    Ohno, N.2    Miura, N.N.3
  • 23
    • 0036545424 scopus 로고    scopus 로고
    • Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion
    • Inoue A, Kodama N, Nanba H. Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biol Pharm Bull 2002;25:536-540.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 536-540
    • Inoue, A.1    Kodama, N.2    Nanba, H.3
  • 24
    • 78149282935 scopus 로고    scopus 로고
    • Immunomodulatory activities and subacute toxicity of a novel beta-glucan from Paenibacillus polymyxa JB115 in rats
    • Epub ahead of print
    • Chang ZQ, Reza MA, Lee JS, et al. Immunomodulatory activities and subacute toxicity of a novel beta-glucan from Paenibacillus polymyxa JB115 in rats. Immunopharmacol Immunotoxicol 2010. [Epub ahead of print]
    • (2010) Immunopharmacol. Immunotoxicol.
    • Chang, Z.Q.1    Reza, M.A.2    Lee, J.S.3
  • 25
    • 15744362964 scopus 로고    scopus 로고
    • IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and nonstimulatory amounts of microparticulate beta-glucan
    • Berner MD, Sura ME, Alves BN, Hunter KW Jr. IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and nonstimulatory amounts of microparticulate beta-glucan. Immunol Lett 2005;98:115-122.
    • (2005) Immunol. Lett. , vol.98 , pp. 115-122
    • Berner, M.D.1    Sura, M.E.2    Alves, B.N.3    Hunter Jr., K.W.4
  • 26
    • 13844294158 scopus 로고    scopus 로고
    • Combined immunomodulating effects of BCG and lentinan after intranasal application in guinea pigs
    • Drandarska I, Kussovski V, Nikolaeva S, Markova N. Combined immunomodulating effects of BCG and lentinan after intranasal application in guinea pigs. Int Immunopharmacol 2005;5:795-803.
    • (2005) Int. Immunopharmacol , vol.5 , pp. 795-803
    • Drandarska, I.1    Kussovski, V.2    Nikolaeva, S.3    Markova, N.4
  • 27
    • 0141788129 scopus 로고    scopus 로고
    • Enhanced cytokine synthesis of leukocytes by a beta-glucan preparation, SCG, extracted from a medicinal mushroom, Sparassis crispa
    • Nameda S, Harada T, Miura NN, et al. Enhanced cytokine synthesis of leukocytes by a beta-glucan preparation, SCG, extracted from a medicinal mushroom, Sparassis crispa. Immunopharmacol Immunotoxicol 2003;25:321-335.
    • (2003) Immunopharmacol. Immunotoxicol. , vol.25 , pp. 321-335
    • Nameda, S.1    Harada, T.2    Miura, N.N.3
  • 28
    • 58149340281 scopus 로고    scopus 로고
    • Beta-glucan, immune function, and upper respiratory tract infections in athletes
    • Nieman DC, Henson DA, McMahon M, et al. Beta-glucan, immune function, and upper respiratory tract infections in athletes. Med Sci Sports Exerc 2008;40:1463-1471.
    • (2008) Med. Sci. Sports Exerc. , vol.40 , pp. 1463-1471
    • Nieman, D.C.1    Henson, D.A.2    McMahon, M.3
  • 30
    • 45549109834 scopus 로고    scopus 로고
    • Benefits of oat beta-glucan on respiratory infection following exercise stress: Role of lung macrophages
    • Murphy EA, Davis JM, Brown AS, et al. Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 2008;294:R1593-R1599.
    • (2008) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.294
    • Murphy, E.A.1    Davis, J.M.2    Brown, A.S.3
  • 31
    • 0042928208 scopus 로고    scopus 로고
    • Protective activity of lentinan in experimental tuberculosis
    • Markova N, Kussovski V, Drandarska I, et al. Protective activity of lentinan in experimental tuberculosis. Int Immunopharmacol 2003;3:1557-1562.
    • (2003) Int. Immunopharmacol , vol.3 , pp. 1557-1562
    • Markova, N.1    Kussovski, V.2    Drandarska, I.3
  • 32
    • 0033964815 scopus 로고    scopus 로고
    • Protective effect of beta-glucan against systemic Streptococcus pneumoniae infection in mice
    • Hetland G, Ohno N, Aaberge IS, Lovik M. Protective effect of beta-glucan against systemic Streptococcus pneumoniae infection in mice. FEMS Immunol Med Microbiol 2000;27:111-116.
    • (2000) FEMS Immunol. Med. Microbiol. , vol.27 , pp. 111-116
    • Hetland, G.1    Ohno, N.2    Aaberge, I.S.3    Lovik, M.4
  • 33
    • 43649108725 scopus 로고    scopus 로고
    • Sulfated beta-glucan derived from oat bran with potent anti-HIV activity
    • Wang SC, Bligh SW, Zhu CL, et al. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity. J Agric Food Chem 2008;56:2624-2629.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 2624-2629
    • Wang, S.C.1    Bligh, S.W.2    Zhu, C.L.3
  • 35
    • 6544262055 scopus 로고    scopus 로고
    • A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: A phase I/II trial
    • Gordon M, Bihari B, Goosby E, et al. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial. J Med 1998;29:305-330.
    • (1998) J. Med. , vol.29 , pp. 305-330
    • Gordon, M.1    Bihari, B.2    Goosby, E.3
  • 36
    • 0027986554 scopus 로고
    • Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients
    • Babineau TJ, Marcello P, Swails W, et al. Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients. Ann Surg 1994;220:601-609.
    • (1994) Ann. Surg. , vol.220 , pp. 601-609
    • Babineau, T.J.1    Marcello, P.2    Swails, W.3
  • 37
    • 0027367184 scopus 로고
    • Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1!3 polyglucose (glucan)
    • De Felippe Junior J, da Rocha e Silva Junior M, Maciel FM, et al. Infection prevention in patients with severe multiple trauma with the immunomodulator beta 1!3 polyglucose (glucan). Surg Gynecol Obstet 1993;177:383-388.
    • (1993) Surg. Gynecol. Obstet. , vol.177 , pp. 383-388
    • De Felippe Jr., J.1    Da Rocha E Silva Jr., M.2    Maciel, F.M.3
  • 38
    • 4344663851 scopus 로고    scopus 로고
    • Effects of moderate exercise and oat beta-glucan on lung tumor metastases and macrophage antitumor cytotoxicity
    • Murphy EA, Davis JM, Brown AS, et al. Effects of moderate exercise and oat beta-glucan on lung tumor metastases and macrophage antitumor cytotoxicity. J Appl Physiol 2004;97:955-959.
    • (2004) J. Appl. Physiol. , vol.97 , pp. 955-959
    • Murphy, E.A.1    Davis, J.M.2    Brown, A.S.3
  • 39
    • 77953976275 scopus 로고    scopus 로고
    • Lentinan: Hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia
    • McCormack E, Skavland J, Mujic M, et al. Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. Nutr Cancer 2010;62:574-583.
    • (2010) Nutr. Cancer , vol.62 , pp. 574-583
    • McCormack, E.1    Skavland, J.2    Mujic, M.3
  • 40
    • 70349229758 scopus 로고    scopus 로고
    • Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice
    • Niu YC, Liu JC, Zhao XM, et al. Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. Pharmazie 2009;64:472-476.
    • (2009) Pharmazie , vol.64 , pp. 472-476
    • Niu, Y.C.1    Liu, J.C.2    Zhao, X.M.3
  • 41
    • 76949094767 scopus 로고    scopus 로고
    • The effects of beta-glucan on human immune and cancer cells
    • Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol 2009;2:25.
    • (2009) J. Hematol. Oncol. , vol.2 , pp. 25
    • Chan, G.C.1    Chan, W.K.2    Sze, D.M.3
  • 43
    • 36649038772 scopus 로고    scopus 로고
    • Antitumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae
    • Yoon TJ, Kim TJ, Lee H, et al. Antitumor metastatic activity of beta-glucan purified from mutated Saccharomyces cerevisiae. Int Immunopharmacol 2008;8:36-42.
    • (2008) Int. Immunopharmacol , vol.8 , pp. 36-42
    • Yoon, T.J.1    Kim, T.J.2    Lee, H.3
  • 44
    • 33845231348 scopus 로고    scopus 로고
    • Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
    • Tang W, Liu JW, Zhao WM, et al. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 2006;80:205-211.
    • (2006) Life Sci. , vol.80 , pp. 205-211
    • Tang, W.1    Liu, J.W.2    Zhao, W.M.3
  • 45
    • 33744540109 scopus 로고    scopus 로고
    • Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
    • Muller CI, Kumagai T, O'Kelly J, et al. Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk Res 2006;30:841-848.
    • (2006) Leuk Res. , vol.30 , pp. 841-848
    • Muller, C.I.1    Kumagai, T.2    O'Kelly, J.3
  • 46
    • 33845195134 scopus 로고    scopus 로고
    • Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer
    • Demir G, Klein HO, Mandel-Molinas N, Tuzuner N. Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. Int Immunopharmacol 2007;7:113-116.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 113-116
    • Demir, G.1    Klein, H.O.2    Mandel-Molinas, N.3    Tuzuner, N.4
  • 47
    • 64949120589 scopus 로고    scopus 로고
    • Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer
    • Shimizu K, Shimizu K, Watanabe S, Matsuda K, et al. Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer. Hepatogastroenterology 2009;56:240-244.
    • (2009) Hepatogastroenterology , vol.56 , pp. 240-244
    • Shimizu, K.1    Shimizu, K.2    Watanabe, S.3    Matsuda, K.4
  • 48
    • 69249187521 scopus 로고    scopus 로고
    • Efficacy of orally administered • superfine dispersed lentinan (beta-1, 3-glucan) for the treatment of advanced colorectal cancer
    • This study assessed the efficacy of β-glucan from lentinin on quality of life scores in advanced colorectal cancer patients. Patients with low quality of life scores n = 23 reported a significant improvement in their score following 12 weeks of β-glucan treatment. The binding of peripheral blood monocytes to β-glucan appeared to be a predictor of quality of life improvement
    • Hazama S, Watanabe S, Ohashi M, et al. Efficacy of orally administered • superfine dispersed lentinan (beta-1, 3-glucan) for the treatment of advanced colorectal cancer. Anticancer Res 2009;29:2611-2617. This study assessed the efficacy of β-glucan from lentinin on quality of life scores in advanced colorectal cancer patients. Patients with low quality of life scores (n = 23) reported a significant improvement in their score following 12 weeks of β-glucan treatment. The binding of peripheral blood monocytes to β-glucan appeared to be a predictor of quality of life improvement.
    • (2009) Anticancer Res. , vol.29 , pp. 2611-2617
    • Hazama, S.1    Watanabe, S.2    Ohashi, M.3
  • 49
    • 67649158338 scopus 로고    scopus 로고
    • Clinical efficacy of superfine dispersed • lentinan (beta-1, 3-glucan) in patients with hepatocellular carcinoma
    • + monocytes was a promising prognostic predictor; survival time of the lentinin-high-binding group was significantly longer than that of the lentinin-low-binding group
    • + monocytes was a promising prognostic predictor; survival time of the lentinin-high-binding group was significantly longer than that of the lentinin-low-binding group.
    • (2009) Hepatogastroenterology , vol.56 , pp. 437-441
    • Isoda, N.1    Eguchi, Y.2    Nukaya, H.3
  • 50
    • 69249174129 scopus 로고    scopus 로고
    • Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer
    • Oba K, Kobayashi M, Matsui T, et al. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer. Anticancer Res 2009;29:2739-2745.
    • (2009) Anticancer Res. , vol.29 , pp. 2739-2745
    • Oba, K.1    Kobayashi, M.2    Matsui, T.3
  • 51
    • 67649197058 scopus 로고    scopus 로고
    • Lentinan with S-1 and paclitaxel for • gastric cancer chemotherapy improve patient quality of life
    • This study showed that lentinin combined with cancer chemotherapy throughout the treatment period can improve quality of life in gastric cancer patients
    • Kataoka H, Shimura T, Mizoshita T, et al. Lentinan with S-1 and paclitaxel for • gastric cancer chemotherapy improve patient quality of life. Hepatogastroenterology 2009;56:547-550. This study showed that lentinin combined with cancer chemotherapy throughout the treatment period can improve quality of life in gastric cancer patients.
    • (2009) Hepatogastroenterology , vol.56 , pp. 547-550
    • Kataoka, H.1    Shimura, T.2    Mizoshita, T.3
  • 52
    • 0027322814 scopus 로고
    • Improvement of long-term prognosis in patients with ovarian cancers by adjuvant sizofiran immunotherapy: A prospective randomized controlled study
    • Inoue M, Tanaka Y, Sugita N, et al. Improvement of long-term prognosis in patients with ovarian cancers by adjuvant sizofiran immunotherapy: a prospective randomized controlled study. Biotherapy 1993;6:13-18.
    • (1993) Biotherapy , vol.6 , pp. 13-18
    • Inoue, M.1    Tanaka, Y.2    Sugita, N.3
  • 53
    • 0036307685 scopus 로고    scopus 로고
    • Can maitake MD-fraction aid cancer patients?
    • Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients? Altern Med Rev 2002;7:236-239.
    • (2002) Altern Med. Rev. , vol.7 , pp. 236-239
    • Kodama, N.1    Komuta, K.2    Nanba, H.3
  • 55
    • 68449085050 scopus 로고    scopus 로고
    • Effect of yeast-derived beta-glucan in • conjunction with bevacizumab for the treatment of human lung adenocarcinoma in subcutaneous and orthotopic xenograft models
    • This study reported that β-glucan enhances the efficacy of benacizumab, a monoclonal antibody against vascular endothelial growth factor VEGF, in terms of tumor progression and long-term survival in a xenograft model of human lung adenocarcinoma. The authors suggest that this combination therapy may provide clinical benefits for human lung cancer patients
    • Zhong W, Hansen R, Li B, et al. Effect of yeast-derived beta-glucan in • conjunction with bevacizumab for the treatment of human lung adenocarcinoma in subcutaneous and orthotopic xenograft models. J Immunother 2009;32:703-712. This study reported that β-glucan enhances the efficacy of benacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), in terms of tumor progression and long-term survival in a xenograft model of human lung adenocarcinoma. The authors suggest that this combination therapy may provide clinical benefits for human lung cancer patients
    • (2009) J. Immunother. , vol.32 , pp. 703-712
    • Zhong, W.1    Hansen, R.2    Li, B.3


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